Cytomegalovirus viral load testing of blood using quantitative polymerase chain reaction in acutely unwell HIV-1-positive patients lacks diagnostic utility

International Journal of STD and AIDS

Volumn 18, Issue 5, 2007, Pages 321-323

  Edwards, S G ^a   Grover, D ^a   Scott, C ^a   Tedder, R S ^b   Pillay, D ^b   Copas, A ^b   Miller, R F ^b,c  

^a Camden Primary Care Trust   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cytomegalovirus infection; HIV infection; Polymerase chain reaction; Viraemia; Viral load

Indexed keywords

ARTICLE; BLOOD SAMPLING; CD4 LYMPHOCYTE COUNT; COLITIS; CYTOMEGALOVIRUS; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; ENCEPHALITIS; ENDOSCOPY; ESOPHAGITIS; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG LAVAGE; MAJOR CLINICAL STUDY; OPTIC NEURITIS; PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETINITIS; VIRUS DETECTION; VIRUS LOAD; ACUTE DISEASE; BLOOD; CYTOMEGALIC INCLUSION BODY DISEASE; EVALUATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; METHODOLOGY; POLYMERASE CHAIN REACTION; PREDICTION AND FORECASTING; RETROSPECTIVE STUDY; STATISTICS; VIREMIA;

VIRUS DNA;

ACUTE DISEASE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; VIRAL LOAD; VIREMIA;

EID: 34447128169     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/095646207780749600     Document Type: Article

References (8)

1. Bowen EF, Sabin CA, Wilson P, et al. Cytomegalovirus (CMV) viraemia detected by polymerase chain reaction identifies a group of HIV-positive patients at high risk of CMV disease. AIDS 1997;7:889-93
2. Deayton JR, Sabin CA, Johnson MA, Emery VC, Wilson P, Griffiths PD. Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy. Lancet 2004;363:2116-21
3. Spector SA, Wong R, Hsia K, Pilcher M, Stempien MJ. Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients. J Clin Invest 1998;101:497-502
4. Jabs DA, Martin BK, Forman MS, Ricks MO. Cytomegalovirus (CMV) blood DNA load, CMV retinitis progression, and occurrence of resistant CMV in patients with CMV retinitis. J Infect Dis 2005;192:640-9
5. Preiser W, Brink NS, Ayliffe U, et al. Development and clinical application of a fully controlled quantitative PCR assay for cell-free cytomegalovirus in human plasma. J Clin Virol 2003;26:49-59
6. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002;34:1094-7
7. Spector SA, McKinley GF, Lalezari JP, et al. Oral ganciclovir for the prevention of cytomegalovirus disease in persons with AIDS. N Engl J Med 1996;334:1491-7
8. Wohl D, Kendall M, Andersen J, et al. Randomised, placebo controlled trial of valganciclovir to prevent CMV end-organ disease among HIV-infected subjects with detectable plasma CMV DNA PCR: ACTG 5030 Thirteenth Conference on Retroviruses and Opportunistic Infections, Denver, USA, February 2006; Abstract 150