B12 deficiency: A look beyond pernicious anemia

Journal of Family Practice

Volumn 56, Issue 7, 2007, Pages 537-542

  Andrès, Emmanuel ^a,e   Federici, Laure ^a   Affenberger, Stéphan ^a   Vidal Alaball, Josep ^b   Loukili, Noureddine Henoun ^c   Zimmer, Jacques ^d   Kaltenbach, Georges ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^e HÔPITAL CIVIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTACID AGENT; CYANOCOBALAMIN; HYDROXOCOBALAMIN; METFORMIN;

CYANOCOBALAMIN DEFICIENCY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MALABSORPTION; MEGALOCYTOSIS; PERNICIOUS ANEMIA; REVIEW; SENSORY NEUROPATHY; INTRAMUSCULAR DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; POSTOPERATIVE COMPLICATION;

ADMINISTRATION, ORAL; ANEMIA, PERNICIOUS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INJECTIONS, INTRAMUSCULAR; MALABSORPTION SYNDROMES; POSTOPERATIVE COMPLICATIONS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 34447109614     PISSN: 00943509     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (49)

1. Carmel R. Current concepts in cobalamin deficiency. Ann Rev Med 2000; 51:357-375.
2. Andrès E, Perrin AE, Kraemer JP, et al. Anémies par carence en vitamine B12 chez le sujet âgé de plus de 75 ans: nouveaux concepts. A propos de 20 observations. Rev Med Interne 2000; 21:946-955.
3. Pautas E, Chérin P, De Jaeger C, Godeau P. Carence en vitamine B12 chez le sujet âgé. Presse Med 1999; 28:1767-1770.
4. Carmel R. Malabsorption of food-cobalamin. Bailliere's Clin Haematol 1995; 8:639-655.
5. Andrès E, Affenberger S, Vinzio S, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med 2005; 118:1154-1159.
6. Carmel R, Sarrai M. Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies. Curr Hematol Rep 2006; 5:23-33.
7. Matthews JH. Cobalamin and folate deficiency in the elderly. Baillère's Clin Haematol 1995; 54:245-253.
8. Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60:2-11.
9. van Asselt DZ, Blom HJ, Zuiderent R, et al. Clinical significance of low cobalamin levels in older hospital patients. Neth J Med 2000; 57:41-49.
10. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990; 76:871-881.
11. Dharmarajan TS, Adiga GU, Norkus EP. Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Geriatrics 2003; 58:30-38.
12. Andrès E, Affenberger S, Zimmer J, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol 2006; 28:50-56.
13. Andrès E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CAMJ 2004; 171:251-260.
14. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006; 5:949-960.
15. Abyad A. Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging 2002; 6:254-260.
16. Lane LA, Rojas-Fernandez C. Treatment of vitamin B12 deficiency anemia: oral versus parenteral therapy. Ann Pharmacother 2002; 36:1268-1272.
17. Andrès E, Kaltenbach G. Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging 2003; 7:309-310.
18. Klee GG. Cobalamin and folate evaluation: measurements of methylmalonic acid and homocystein vs vitamin B12 and folate. Clin Chem 2000; 46: 12e77-1283.
19. Nicolas JP, Guéant JL. Absorption, distribution et excrétion de la vitamine B12. Ann Gastroenterol Hepatol 1994; 30:270-282.
20. Loukili NH, Noel E, Blaison G, et al. Données actuelles sur la maladie de Biermer. A propos d'une étude retrospective de 49 patients. Rev Med Interne 2004; 25:556-561.
21. Toh BH, van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med 1997; 337:1441-1448.
22. Pruthi RK, Tefferi A. Pernicious anemia revisited. Mayo Clin Proc 1994; 69:144-150.
23. Institute of Medicine. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, panthothenic acid, biotin and choline. Food and Nutrition Board, Washington, DC. National Academies Press, 1998.
24. Andrés E, Noel E, Kaltenbach G, et al. Carences en vitamine B12 avec test de Schilling normal ou syndrome de non-dissociation de la vitamine B12 de ses protéines porteuses chez le sujet âgé. Etude de 60 patients. Rev Med Interne 2003; 24:218-223.
25. Carmel R, Aurangzeb I, Ojan D. Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. Am J Gastroenterol 2001; 96:63-70.
26. Kaptan K, Beyan C, Ural AU, et al. Helicobacter pylori - is it a novel causative agent in Vitamin B12 deficiency? Arch Intern Med 2000; 160:1349-1353.
27. Howden CW. Vitamin B12 levels during prolonged treatment with proton pump inhibitors. J Clin Gastroenterol 2000; 30:29-33.
28. Andrès E, Noel E, Ben Abdelghani M. Vitamin B12 deficiency associated with chronic acid suppression therapy. Ann Pharmacother 2003; 37:1730.
29. Termanini B, Gibril F, Sutliff VE, Yu F, Venzon DJ, Jensen RT. Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998; 104:422-430.
30. Jensen RT. Consequences of long-term proton pump blockade: insights from studies of patients with gastrinomas. Basic Clin Pharmacol Toxicol 2006; 98:4-19.
31. Bauman WA, Shaw S, Javatilleke E, Spungen AM, Herbert V. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000; 23:1227-1231.
32. Andrès E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency. Arch Intern Med 2002; 162:2251-2252.
33. Liu KW, Dai LK, Jean W. Metformin-related vitamin B12 deficiency. Age Aging 2006; 35:200-201.
34. Andrès E, Goichot B, Perrin AE, Vinzio S, Demangeat C, Schlienger JL. Sjögren's syndrome: a potential new cause of mild cobalamin deficiency. Rheumatology (Oxford) 2001; 40:1196-1197.
35. Kuzminski AM, Del Giacco El, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 1998; 92:1191-1198.
36. Elia M. Oral or parenteral therapy for B12 deficiency. Lancet 1998; 352:1721-1722.
37. Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther 2003; 25:3124-3134.
38. Andrès E, Kaltenbach G, Noel E, et al. Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption. A study of 30 patients. Clin Lab Haematol 2003; 25:161-166.
39. Andrès E, Kurtz JE, Perrin AE, et al. Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption. Am J Med 2001; 111:126-129.
40. Kaltenbach G, Noblet-Dick M, Andrès E, et al. Rèponse prècoce au traitement oral par vitamine B12 chez des sujets âgés hypovitaminiques. Ann Med Interne (Paris) 2003; 154:91-95.
41. Andrès E, Kaltenbach G, Noblet-Dick M, et al. Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients. J Nutr Health Aging 2006; 10:3-6.
42. Butler CC, Vidal-Alaball J, Cannings-John R, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Fam Pract 2006; 23:279-285.
43. Slot WB, Merkus FW, Van Deventer SJ, Tytgat GN. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology 1997; 113:430-433.
44. van Asselt DZ, Merkus FW, Russel FG, Hoefnagels WH. Nasal absorption of hydroxocobalamin in healthy elderly adults. Br J Clin Pharmacol 1998; 45:83-86.
45. Andrès E, Loukili NH, Noel E, et al. Oral cobalamin (daily dose of 1000 μg) therapy for the treatment of patients with pernicious anemia. An open label study of 10 patients. Curr Ther Res 2005; 66:13-22.
46. Vidal-Alaball J, Butler CC, Cannings-John R, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev 2005; 20:CD004655.
47. Eussen SJ, de Groot LC, Clarke R, et al. Oral cyano-cobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med 2005; 165:1167-1172.
48. Roth M, Orija I. Oral vitamin B12 therapy in vitamin B12 deficiency. Am J Med 2004; 116:358.
49. Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL. Oral cobalamin remains medicine's best kept secret. Arch Gerontol Geriatr 2007; 44:49-59.