Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency;Réponse précoce au traitement oral par vitamine B12 chez des sujets âgés hypovitaminiques

Annales de Medecine Interne

Volumn 154, Issue 2, 2003, Pages 91-95

  Kaltenbach, Georges ^a   Noblet Dick, Marie ^a   Andrès, Emmanuel ^b   Barnier Figue, Geneviève ^a   Noel, Ester ^b   Vogel, Thomas ^a   Perrin, Anne Elisabeth ^c   Martin Hunyadi, Catherine ^a   Berthel, Marc ^a   Kuntzmann, Francis ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b HÔPITAL CIVIL   (France)

^c HÔPITAL DE HAUTEPIERRE   (France)

Author keywords

Aged; Cobalamin deficiency; Food cobalamin malabsorption; Nutritional deficiency; Oral cyanocobalamin treatment

Indexed keywords

CYANOCOBALAMIN; HEMOGLOBIN;

AGED; ARTICLE; BLOOD CELL COUNT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DRUG EFFICACY; DRUG RESPONSE; ELDERLY CARE; ERYTHROCYTE VOLUME; HEMOGLOBIN DETERMINATION; HUMAN; INJECTION PAIN; MALABSORPTION; NUTRITIONAL DEFICIENCY; RETICULOCYTE COUNT; TREATMENT OUTCOME; VITAMIN BLOOD LEVEL; BLOOD; DRUG EFFECT; FEMALE; MALE; ORAL DRUG ADMINISTRATION; PROSPECTIVE STUDY; REFERENCE VALUE;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; ERYTHROCYTE VOLUME; FEMALE; HEMOGLOBINS; HUMANS; MALABSORPTION SYNDROMES; MALE; PROSPECTIVE STUDIES; REFERENCE VALUES; RETICULOCYTE COUNT; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 0042822250     PISSN: 0003410X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. LINDENBAUM J, ROSENBERG IH, WILSON PW, STABLER SP, ALLEN RH: Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr, 1994; 60: 2-11.
2. PAUTAS E, CHÉRIN P, DE JAEGER C, GODEAU P: Carence en vitamine B12 chez le sujet âgé. Presse Med, 1999; 28: 1767-70.
3. ANDRES E, PERRIN AE, KRAEMER JP, GOICHOT B, DEMENGEAT C, RUELLAN A, et al.: Anémies par carence en vitamine B12 chez le sujet âgé de plus de 75 ans: nouveaux concepts. À propos de 20 observations. Rev Med Interne, 2000; 21: 946-54.
4. VERHAEVERBEKE I, METS T, MULKENS K, VANDEWOUDE M: Normalization of low vitamin B12 serum levels in older people by oral treatment. J Am Geriatr Soc, 1997; 45: 124-5.
5. ANDRÈS E, KURTZ JE, PERRIN AE, MALOISEL F, DEMANGEAT C, GOICHOT B, et al.: Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption. Am J Med, 2001; 111: 126-9.
6. RUSSEL RM: Vitamin requirements in old age. Age Nutrition, 1992; 3: 20-3.
7. CARMEL R: Malabsorption of food cobalamin. Baillieres Clin Haematol, 1995; 8: 639-55.
8. SNOW CF: Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med, 1999; 159: 1289-98.
9. SAVAGE DG, LINDENBAUM J, STABLER SP, ALLEN RH: Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med, 1994; 96: 239-46.
10. LINDENBAUM J, HEALTON EB, SAVAGE DG, BRUST JC, GARRETT TJ, PODELL ER, et al.: Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med, 1988; 318: 1720-8.
11. VAN ASSELT DZ, BLOM HJ, ZUIDERENT R, WEVERS RA, JAKOBS C, VAN DEN BROEK WJ, et al.: Clinical significance of low cobalamin levels in older hospital patients. Neth J Med, 2000; 57: 41-9.
12. KUZMINSKI AM, DEL GIACCO EJ, ALLEN RH, STABLER SP, LINDENBAUM J: Effective treatment of cobalamin deficiency with oral cobalamin. Blood, 1998; 92: 1191-8.
13. KONDO H: Haematological effects of oral cobalamin preparations on patients with megaloblastic anemia. Acta Haematol, 1998; 99: 200-5.
14. TOH BH, VAN DRIEL IR, GLEESON PA: Pernicious anemia. N Engl J Med, 1997; 337: 1441-8.
15. 12 without intrinsic factor. Acta Med Scand, 1968; 184: 247-58.
16. BERLIN R, BERLIN H, BRANTE G, PILBRANT A: Vitamin B12 body stores during oral and parenteral treatment of pernicious anemia. Acta Med Scand, 1978; 204: 81-4.
17. BRADA N, GORDON MM, WEN J, ALPERS DH: Transfer of cobalamin from intrinsic factor to transcobalamin II. J Nutr Biochem, 2001; 12: 200-6.
18. LEDERLE FA: Oral cobalamin for pernicious anemia. Medicine's best-kept secret? JAMA, 1991; 265: 94-5.
19. ELIA M: Oral or parenteral therapy for B12 deficiency. Lancet, 1998; 352: 1721-2.
20. VAN WALRAVEN C, AUSTIN P, NAYLOR CD: Vitamin B12 injections versus oral supplements. How much money could be saved by switching from injections to pills? Can Fam Physician, 2001; 47: 79-86.