Growth plate zonal microarray analysis shows upregulation of extracellular matrix genes and downregulation of metalloproteinases and cathepsins following irradiation

Calcified Tissue International

Volumn 81, Issue 1, 2007, Pages 26-38

  Zhang, Mingliang ^a   Wang, Yan ^a   Middleton, Frank A ^a   Horton, Jason A ^a   Farnum, Cornelia E ^b   Damron, Timothy A ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Chondrocyte; Growth plate; Microarray; Radiotherapy

Indexed keywords

CATHEPSIN; CATHEPSIN K; EZRIN; INTEGRIN; METALLOPROTEINASE; MOESIN; PROCOLLAGEN; RADIXIN; SIALOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX GENE; GENE; GENE EXPRESSION; GENE FUNCTION; GROWTH PLATE; IN SITU HYBRIDIZATION; LASER MICRODISSECTION; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TIBIA; UPREGULATION; X IRRADIATION; X RAY;

ANIMALS; CATHEPSINS; CELL PROLIFERATION; CHONDROCYTES; DOWN-REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GROWTH PLATE; LEUCINE; MALE; METALLOPROTEASES; NUCLEIC ACID HYBRIDIZATION; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 34447097463     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-007-9025-1     Document Type: Article

References (34)

1. Goldwein JW (1991) Effects of radiation therapy on skeletal growth in childhood. Clin Orthop 262:101-107
2. Damron TA, Mathur S, Horton JA, Strauss J, Margulies B, Grant W, Farnum CE, Spadaro JA (2004) Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant. J Histochem Cytochem 52:157-167
3. Sandell LJ, Sugai JV, Trippel SB (1994) Expression of collagens I, II, X, and XI and aggrecan mRNAs by bovine growth plate chondrocytes in situ. J Orthop Res 12:1-14
4. Fukunaga T, Yamashiro T, Oya S, Takeshita N, Takigawa M, Takano-Yamamoto T (2003) Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression. Bone 33:911-918
5. Unsold C, Pappano WN, Imamura Y, Steiglitz BM, Greenspan DS (2002) Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases. J Biol Chem 277:5596-5602
6. Wang Y, Middleton F, Horton JA, Reichel L, Farnum CE, Damron TA (2004) Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone 35:1273-1293
7. Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P (2002) Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 22:2718-2729
8. Weinreb M, Shinar D, Rodan GA (1990) Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization. J Bone Miner Res 5:831-842
9. DeRisi JL, Iyer VR, Brown PO (1997) Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680-686
10. Abdul M, Hoosein N (2000) Changes in beta-2 microglobulin expression in prostate cancer 5:168-172
11. Zhang H, Liew CC, Marshall KW (2002) Microarray analysis reveals the involvement of beta-2 microglobulin (B2M) in human osteoarthritis. Osteoarthritis Cartilage 10:950-960
12. Matsuoka Y, Li X, Bennett V (2000) Adducin: structure, function and regulation. Cell Mol Life Sci 57:884-895
13. Fukata Y, Oshiro N, Kinoshita N, Kawano Y, Matsuoka Y, Bennett V, Matsuura Y, Kaibuchi K (1999) Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol 145:347-361
14. Singh A, Hitchcock-DeGregori SE (2003) Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding. Biochemistry 42:14114-14121
15. Xie L, Law BK, Aakre ME, Edgerton M, Shyr Y, Bhowmick NA, Moses HL (2003) Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res 5:R187-R198
16. Gustafsson E, Aszodi A, Ortega N, Hunziker EB, Denker HW, Werb Z, Fassler R (2003) Role of collagen type II and perlecan in skeletal development. Ann N Y Acad Sci 995:140-150
17. Brekken RA, Sage EH (2001) SPARC, a matricellular protein: at the crossroads of cell-matrix communication. Matrix Biol 19:816-827
18. Bengtsson E, Morgelin M, Sasaki T, Timpl R, Heinegard D, Aspberg A (2002) The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. J Biol Chem 277:15061-15068
19. Marshansky V, Wang X, Bertrand R, Luo H, Duguid W, Chinnadurai G, Kanaan N, Vu MD, Wu J (2001) Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells. J Immunol 166:3130-3142
20. Loveridge N, Farquharson C, Hesketh JE, Jakowlew SB, Whitehead CC, Thorp BH (1993) The control of chondrocyte differentiation during endochondral bone growth in vivo: changes in TGF-beta and the proto-oncogene c-myc. J Cell Sci 105(pt 4):949-956
21. Shen Z, Gantcheva S, Mansson B, Heinegard D, Sommarin Y (1998) Chondroadherin expression changes in skeletal development. Biochem J 330(pt 1):549-557
22. Neame PJ, Tapp H, Azizan A (1999) Noncollagenous, nonproteoglycan macromolecules of cartilage. Cell Mol Life Sci 55:1327-1340
23. Worapamorn W, Xiao Y, Li H, Young WG, Bartold PM (2002) Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat. J Periodontal Res 37:293-299
24. Knudson CB, Knudson W (2001) Cartilage proteoglycans. Semin Cell Dev Biol 12:69-78
25. Gregory KE, Keene DR, Tufa SF, Lunstrum GP, Morris NP (2001) Developmental distribution of collagen type XII in cartilage: association with articular cartilage and the growth plate. J Bone Miner Res 16:2005-2016
26. Martin TA, Harrison G, Mansel RE, Jiang WG (2003) The role of the CD44/ezrin complex in cancer metastasis. Crit Rev Oncol Hematol 46:165-186
27. Bretscher A, Edwards K, Fehon RG (2002) ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 3:586-599
28. Hiscox S, Jiang WG (1999) Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. J Cell Sci 112(pt 18):3081-3090
29. Masumoto J, Sagara J, Hayama M, Hidaka E, Katsuyama T, Taniguchi S (1998) Differential expression of moesin in cells of hematopoietic lineage and lymphatic systems. Histochem Cell Biol 110:33-41
30. Iozzo RV (1999) The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem 274:18843-18846
31. Wilda M, Bachner D, Just W, Geerkens C, Kraus P, Vogel W, Hameister H (2000) A comparison of the expression pattern of five genes of the family of small leucine-rich proteoglycans during mouse development. J Bone Miner Res 15:2187-2196
32. Raouf A, Ganss B, McMahon C, Vary C, Roughley PJ, Seth A (2002) Lumican is a major proteoglycan component of the bone matrix. Matrix Biol 21:361-367
33. Santra M, Mann DM, Mercer EW, Skorski T, Calabretta B, Iozzo RV (1997) Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest 100:149-157
34. Petersson U, Hultenby K, Wendel M (2003) Identification, distribution and expression of osteoadherin during tooth formation. Eur J Oral Sci 111:128-136