Noncollagenous, nonproteoglycan macromolecules of cartilage

Cellular and Molecular Life Sciences

Volumn 55, Issue 10, 1999, Pages 1327-1340

  Neame, P J ^a,b   Tapp, H ^b   Azizan, A ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Bone; Cartilage; Development; Protein structure; Skeleton

Indexed keywords

CELL PROTEIN; COLLAGEN; GLYCOPROTEIN; LECTIN; MATRIX PROTEIN; PLEIOTROPHIN; PROTEOGLYCAN;

CARTILAGE CELL; CARTILAGE MATRIX; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CARTILAGE; CHROMOSOME MAPPING; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; HUMANS;

EID: 0033567396     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050373     Document Type: Review

References (141)

1. 1 Hocking A. M., Shinomura T. and McQuillan D. J. (1998) Leucine-rich repeat glycoproteins of the extracellular matrix. Matrix Biol. 17: 1-19
2. 2 Shukunami C., Ohta Y., Sakuda M. and Hiraki Y. (1998) Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5. Exp. Cell Res. 241: 1-11
3. 3 Johnson R. L., Riddle R. D. and Tabin C. J. (1994) Mechanisms of limb patterning. Curr. Opin. Genet. Dev. 4: 535-542
4. 4 Deng C., Wynshaw-Boris A., Zhou F., Kuo A. and Leder P. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911-921
5. 5 Ernst E. (1998) Shark cartilage for cancer? Lancet 351: 298
6. 6 de Bri, E., Reinholt F. P., Heinegård D., Mengarelli-Widholm S., Norgård M. and Svensson O. (1996) Bone sialoprotein and osteopontin distribution at the osteocartilaginous interface. Clin Orthop: 251-260.
7. 7 Hunziker E. B. (1998) Growth plate formation, structure and function. In: Skeletal Growth and Development: Clinical Issues and Basic Science Advances, pp. 187-202, Buckwalter J. A., Ehrlich M. G., Sandell L. J. and Trippel S. B. (eds), American Academy of Orthopedic Surgeons, Rosemont, IL.
8. 8 Carter D. R., van der Meulen M. C. H. and Beaupré G. S. (1998) Mechanobiological regulation of osteogenesis and arthrogenesis. In: Skeletal Growth and Development: Clinical Issues and Basic Science Advances, pp. 99-130, Buckwalter J. A., Ehrlich M. G., Sandell L. J. and Trippel S. B. (eds), American Academy of Orthopedic Surgeons, Rosemont, IL
9. 9 Sajdera S. W. and Hascall V. C. (1969) Proteinpolysaccharide complex from bovine nasal cartilage. A comparison of low and high shear extraction procedures. J. Biol. Chem. 244: 77-87
10. 10 Neame P. J., Treep J. T. and Young C. N. (1990) An 18 kDa glycoprotein from bovine nasal cartilage. Isolation and primary structure of small, cartilage-derived glycoprotein. J. Biol. Chem. 265: 9628-9633
11. 11 Neame P. J., Young C. N. and Treep J. T. (1990) Isolation and primary structure of PARP. A 24 kDa proline and arginine-rich protein from bovine cartilage closely related to the N-terminal domain in collagen alpha 1(XI). J. Biol. Chem. 265: 20401-20408
12. 12 Larsson T., Sommarin Y., Paulsson M., Antonsson P., Hedbom E., Wendel M. et al. (1991) Cartilage matrix proteins. A basic 36 kDa protein with a restricted distribution to cartilage and bone. J. Biol. Chem. 266: 20428-20433
13. 13 Hocking A. M., Strugnell R. A., Ramamurthy P. and McQuillan D. J. (1996) Eukaryotic expression of recombinant biglycan. Post-translational processing and the importance of secondary structure for biological activity. J. Biol. Chem. 271: 19571-19577
14. 14 Hale J. E. and Wuthier R. E. (1987) The mechanism of matrix vesicle formation. Studies on the composition of chondrocyte microvilli and on the effects of microfilament-perturbing agents on cellular vesiculation. J. Biol. Chem. 262: 1916-1925
15. 15 Recklies A. D. and White C. (1991) Phospholipase A2 is a major component of the salt-extractable pool of matrix proteins in adult human articular cartilage. Arthr. Rheum. 34: 1106-1115
16. 16 Hakala B. E., White C. and Recklies A. D. (1993) Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of the chitinase family. J. Biol. Chem. 268: 25803-25810
17. 17 Hu B., Trinh K., Figueira W. F. and Price P. A. (1996) Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. J. Biol. Chem. 271: 19415-19420
18. 18 Johansen J. S., Hvolris J., Hansen M., Backer V., Lorenzen I. and Price P. A. (1996) Scrum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint. Br. J. Rheumatol. 35: 553-559
19. 19 Kuettner K. E., Guenther H. L., Ray R. D. and Schumacher G. F. (1968) Lysozyme in preosseous cartilage. Calcif. Tissue Res. 1: 298-305
20. 20 Sorgente N., Hascall V. C. and Kuettner K. E. (1972) Extractability of lysozyme from bovine nasal cartilage. Biochim. Biophys. Acta 284: 441-450
21. 21 Melrose J., Ghosh P. and Taylor T. K. (1989) Lysozyme, a major low-molecular-weight cationic protein of the intervertebral disc, which increases with ageing and degeneration. Gerontology 35: 173-180
22. 22 Greenwald R. A. (1976) Lack of effect of lysozymes on cartilage protcoglycans. Arch. Biochem. Biophys. 175: 520-523
23. 23 Mörgelin M., Heinegård D., Engel J. and Paulsson M. (1992) Electron microscopy of native oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure. J. Biol. Chem. 267: 6137-6141
24. 24 Hedbom E., Antonsson P., Hjerpe A., Aeschlimann D., Paulsson M., Rosa-Pimentel R. et al. (1992) Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. J. Biol. Chem. 267: 6132-6136
25. 25 Oldberg A., Antonsson P., Lindblom K. and Heinegård D. (1992) COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins. J. Biol. Chem. 267: 22346-22350
26. 26 DiCesare P. E., Mörgelin M., Carlson C. S., Pasumarti S. and Paulsson M. (1995) Cartilage oligomeric protein: isolation and characterization from human articular cartilage. J. Orthop. Res. 13: 422-428
27. 27 Shen Z., Heinegård D. and Sommarin Y. (1995) Distribution and expression of cartilage oligomeric matrix protein and bone sialoprotein show marked changes during rat femoral head development. Matrix Biol. 14: 773-781
28. 28 Rosenberg K., Olsson H., Morgelin M. and Heinegard D. (1998) Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen. J. Biol. Chem. 273: 20397-20403
29. 29 Newton G., Weremowicz S., Morton C. C., Copeland N. G., Gilbert D. J., Jenkins N. A. et al. (1994) Characterization of human and mouse cartilage oligomeric matrix protein. Genomics 24: 435-439
30. 30 Briggs M. D., Hoffman S. M., King L. M., Olsen A. S., Mohrenweiser H., Leroy J. G. et al. (1995) Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Nat. Genet. 10: 330-336
31. 31 Hecht J. T., Nelson L. D., Crowder E., Wang Y., Elder F. F., Harrison W. R. et al. (1995) Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia. Nat. Genet. 10: 325-329
32. 32 Briggs M. D., Rasmussen I. M., Weber J. L., Yuen J., Reinker K., Garber A. P. et al. (1993) Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19. Genomics 18: 656-660
33. 33 Hecht J. T., Decre M., Putnam E., Cole W., Vertel B., Chen H. et al. (1998) Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues. Matrix Biol. 17: 269-278
34. 34 Qabar A. N., Lin Z., Wolf F. W., O'Shea K. S., Lawler J. and Dixit V. M. (1994) Thrombospondin 3 is a developmentally regulated heparin binding protein. J. Biol. Chem. 269: 1262-1269
35. 35 Saxne T., Glennas A., Kvien T. K., Melby K. and Heinegard D. (1993) Release of cartilage macromolecules into the synovial fluid in patients with acute and prolonged phases of reactive arthritis. Arthr. Rheum. 36: 20-25
36. 36 Sharif M., Saxne T., Shepstone L., Kirwan J. R., Elson C. J., Heinegard D. et al. (1995) Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint. Br. J. Rheumatol. 34: 306-310
37. 37 Haudenschild D. R., Tondravi M. M., Hofer U., Chen Q. and Goetinck P. F. (1995) The role of coiled-coil alpha helices and disulfide bonds in the assembly and stabilization of cartilage matrix protein subunits. A mutational analysis. J. Biol. Chem. 270: 23150-23154
38. 38 Jenkins R. N., Osborne-Lawrence S. L., Sinclair A. K., Eddy R. L. J., Byers M. G., Shows T. B. et al. (1990) Structure and chromosomal location of the human gene encoding cartilage matrix protein. J. Biol. Chem. 265: 19624-19631
39. 39 Argraves W. S., Deàk F., Sparks K. J., Kiss I. and Goetinck P. F. (1987) Structural features of cartilage matrix protein deduced from cDNA. Proc. Natl. Acad. Sci. USA 84: 464-468
40. 40 Aszodi A., Hauser N., Studer D., Paulsson M., Hiripi L. and Bosze Z. (1996) Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNA. Eur. J. Biochem. 236: 970-977
41. 41 Wiltscheck R., Kammerer R. A., Dames S. A., Schulthess T., Blommers M. J., Engel J. et al. (1997) Heteronuclear NMR assignments and secondary structure of the coiled coil trimerization domain from cartilage matrix protein in oxidized and reduced forms. Protein Sci. 6: 1734-1745
42. 42 Hauser N. and Paulsson M. (1994) Native cartilage matrix protein (CMP). A compact trimer of subunits assembled via a coiled-coil alpha helix. J. Biol. Chem. 269: 25747-25753
43. 43 Deak F., Piecha D., Bachrati C., Paulsson M. and Kiss I. (1997) Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily. J. Biol. Chem. 272: 9268-9274
44. 44 Mundlos S., Meyer R., Yamada Y. and Zabel B. (1991) Distribution of cartilage proteoglycan (aggrecan) core protein and link protein gene expression during human skeletal development. Matrix 11: 339-346
45. 45 Chen Q., Johnson D. M., Haudenschild D. R., and Goetinck P. F. (1995) Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev. Biol. 172: 293-306
46. 46 Aszȯdi A., Modis L., Paldi A., Rencendorj A., Kiss I. and Bösze Z. (1994) The zonal expression of chicken cartilage matrix protein gene in the developing skeleton of transgenic mice. Matrix Biol. 14: 181-190
47. 47 Paulsson M., Inerot S. and Heinegård D. (1984) Variation in quantity and extractability of the 148-kilodalton cartilage protein with age. Biochem. J. 221: 623-630
48. 48 Zeineldin R., Ekborg S. and Baker J. (1997) Oligomeric forms of the 148 kDa cartilage matrix protein. Biochem. J. 328: 665-668
49. 49 Chen Q., Johnson D. M., Haudenschild D. R., Tondravi M. M. and Goetinck P. F. (1995) Cartilage matrix protein forms a type II collagen-independent filamentous network: analysis in primary cell cultures with a retrovirus expression system. Mol. Biol. Cell 6: 1743-1753
50. 50 Winterbottom N., Tondravi M. M., Harrington T. L., Klier F. G., Vertel B. M. and Goetinck P. F. (1992) Cartilage matrix protein is a component of the collagen fibril of cartilage. Dev. Dyn. 193: 266-276
51. 51 Neame P. J., Young C. N. and Treep J. T. (1992) Primary structure of a protein isolated from reef shark (Carcharhinus springeri) cartilage that is similar to the mammalian C-type lectin homolog, tetranectin. Protein Science 1: 161-168
52. 52 Neame P. J. and Boynton R. E. (1996) The structure of a C-type lectin isolated from bovine cartilage. In: Techniques in Protein Chemistry, vol. 7, pp. 401-407. Marshak D. (ed.), Academic Press, Orlando, FL
53. 53 Nielsen B. B., Kastrup J. S., Rasmussen H., Holtet T. L., Graversen J-H., Etzerodt M. et al. (1997) Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an a-helical coiled coil. FEBS Lett. 412: 388-396
54. 54 Graversen J. H., Lorentsen R. H., Jacobsen C., Moestrup S. K., Sigurskjold B. W., Thogersen H. C. et al. (1998) The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine. J. Biol. Chem. 273: 29241-29246
55. 55 Lorenzo P., Bayliss M. and Heinegård D. (1998) A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age. J. Biol. Chem. 273: 23463-23468
56. 56 Lorenzo P., Neame P., Sommarin Y. and Heinegård D. (1998) Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphorylase. J. Biol. Chem. 273: 23469-23475
57. 57 Choi H. U., Tang L.-H., Johnson T. L., Pal S., Rosenberg L. C., Reiner A. et al. (1983) Isolation and characterization of a 35,000 molecular weight subunit fetal cartilage matrix protein. J. Biol. Chem. 258: 655-661
58. 58 Poole A. R., Pidoux I., Reiner A., Choi H. and Rosenberg L. C. (1984) Association of an extracellular protein (Chondrocalcin) with the calcification of cartilage in endochondral bone formation. J. Cell Biol. 98: 54-65
59. 59 van der Rest M., Rosenberg L. C., Olsen B. R. and Poole A. R. (1986) Chondrocalcin is identical with the C-propeptide of type II procollagen, Biochem. J. 237: 923-925
60. 60 Davies D., Tuckwell D. S., Calderwood D. A., Weston S. A., Takigawa M. and Humphries M. J. (1997) Molecular characterisation of integrin-procollagen C-propeptide interactions. Eur. J. Biochem. 246: 274-282
61. 61 Nakata K., Miyamoto S., Bernier S., Tanaka M., Utani A., Krebsbach P. et al. (1996) The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription. Ann. N. Y. Acad. Sci. 785: 307-308
62. 62 Kirsch T. and Pfaffle M. (1992) Selective binding of anchorin CH (annexin V) to type II and X collagen and to chondrocalcin (C-propeptide of type II collagen). Implications for anchoring function between matrix vesicles and matrix proteins. FEBS Lett. 310: 143-147
63. 63 von der Mark K. and Mollenhauer J. (1997) Annexin V interactions with collagen. Cell Mol. Life Sci. 53: 539-545
64. 64 Urist M. R., Huo Y. K., Brownell A. G., Hohl W. M., Buyske J., Lietze A. et al. (1984) Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc. Natl. Acad. Sci. USA 81: 371-375
65. 65 Robson P., Sitarz E., Maiti A., Rawat M., Youson J. H. and Keeley F. W. (1993) Characterization of lamprin, an unusual matrix protein from lamprey cartilage. Implications for evolution, structure, and assembly of elastin and other fibrillar proteins. J. Biol. Chem. 268: 1440-1447
66. 66 Lohmander L. S., Neame P. J. and Sandy J. D. (1993) The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury and osteoarthritis. Arthr. Rheum. 36: 1214-1222
67. 374 in the interglobular domain of cartilage aggrecan. Biochem. J. 304: 347-351
68. 68 Vilim V. and Fosang A. J. (1994) Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan. Biochem. J. 304: 887-894
69. 69 Maroudas A., Bayliss M. T., Uchitel-Kaushansky N., Schneiderman R. and Gilav E. (1998) Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch. Biochem. Biophys. 350: 61-71
70. 70 Neame P. J. and Barry F. P. (1993) The link proteins. Experientia 49: 393-402
71. 71 Kohda D., Morton C. J., Parkar A. A., Hatanaka H., Inagaki F. M., Campbell l. D. et al. (1996) Solution structure of the link modulo: a hayluronan-binding domain involved in extracellular matrix stability and cell migration. Cell 86: 767-775
72. 72 Bajorath J., Greenfield B., Munro S. B., Day A. J. and Aruffo A. (1998) Identification of CD44 residues important for hyaluronan binding and delineation of the binding site. J. Biol. Chem. 273: 338-343
73. 73 Kajava A. V. (1998) Structural diversity of leucine-rich repeat proteins. J. Mol. Biol. 277: 519-527
74. 74 Iozzo R. V. (1998) Matrix proteoglycans: from molecular design to cellular function. Annu. Rev. Biochem. 57: 609-652
75. 75 Ramamurthy P., Hocking A. M. and McQuillan D. J. (1996) Recombinant decorin glycoforms. Purification and structure. J. Biol. Chem. 271: 19578-19584
76. 76 Roughley P. J., White R. J., Cs-Szabo G. and Mort J. S. (1996) Changes with age in the structure of fibromodulin in human articular cartilage. Osteoarthritis Cartilage 4: 153-161
77. 77 Grover J., Chen X. N., Korenberg J. R. and Roughley P. J. (1995) The human lumican gene. Organization, chromosomal location and expression in articular cartilage. J. Biol. Chem. 270: 21942-21949
78. 78 Johnstone B., Markopoulos M., Neame P. and Caterson B. (1993) Identification and characterization of glycanated and non-glycanated forms of biglycan and decorin in the human intervertebral disc. Biochem. J. 292: 661-666
79. 79 Roughley P. J., White R. J., Magny M. C., Liu J., Pearce R. H. and Mort J. S. (1993) Non-proteoglycan forms of biglycan increase with age in human articular cartilage. Biochem. J. 295: 421-426
80. 50 Takahashi T., Cho H. I., Kublin C. L. and Cintron C. (1993) Keratan sulfate and dermatan sulfate proteoglycans associate with type VI collagen in fetal rabbit cornea. J. Histochem. Cytochem. 41: 1447-1457
81. 51 Hedbom E. and Heinegård D. (1993) Binding of fibromodulin and decorin to separate sites on fibrillar collagens. J. Biol. Chem. 268: 27307-27312
82. 82 Hildebrand A., Romaris M., Rasmussen L. M., Heinegard D., Twardzik D. R., Border W. A. et al. (1994) Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem. J. 302: 527-534
83. 83 Bengtsson E., Neame P. J., Heinegård D. and Sommarin Y. (1995) The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. J. Biol. Chem. 270: 25639-25660
84. 84 Melching L. I. and Roughley P. J. (1990) A matrix protein of Mr 55,000 that accumulates in human articular cartilage with age. Biochim. Biophys. Acta 1036: 213-220
85. 85 Grover J., Chen X. N., Korenberg J. R., Recklies A. D. and Roughley P. J. (1996) The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage. Genomics 38: 109-117
86. 86 Grover J. and Roughley P. J. (1998) Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor clement. Biochem. J. 336: 77-82
87. 87 Sommarin Y., Larsson T. and Heinegård D. (1989) Chondrocyte matrix interactions. Attachment to proteins isolated from cartilage. Exp. Cell. Res. 184: 181-192
88. 88 Camper L., Heinegard D. and Lundgren-Akerlund E. (1997) Integrin alpha2betal is a receptor for the cartilage matrix protein chondroadherin. J. Cell Biol. 138: 1159-1167
89. 89 Shen Z., Gantcheva S., Mansson B., Heinegard D. and Sommarin Y. (1998) Chondroadherin expression changes in skeletal development. Biochem. J. 330: 549-557
90. 90 Neame P. J., Sommarin Y., Boynton R. E. and Heinegård D. (1994) The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage. J. Biol. Chem. 269: 21547-21554
91. 91 Grover J., Chen X.-N., Korenberg J. R. and Roughley P. J. (1997) The structure and chromosome location of the human chondroadherin gene. Genomics 45: 379-385
92. 92 Landgren C., Beier D. R., Fässler R., Heinegård D. and Sommarin Y. (1998) The mouse chondroadherin gene: characterization and chromosomal localization. Genomics 47: 84-91
93. 93 Zhidkova N. I., Brewton R. G. and Mayne R. (1993) Molecular cloning of PARP (proline/arginine-rich protein) from human cartilage and subsequent demonstration that PARP is a fragment of the NH2-terminal domain of the collagen alpha2(XI) chain. FEBS Lett. 326: 25-28
94. 94 Moradi-Améli M., Deléage G., Geourjon C. and van der Rest M. (1994) Common topology within a non-collagenous domain of several different collagen types. Matrix Biol. 14: 233-239
95. 95 Neame P. J., Young C. N., Brock C. W., Treep J. T., Ganey T. M., Sasse J. et al. (1993) Pleiotrophin is an abundant protein in dissociative extracts of fetal epiphyseal cartilage and newborn nasal cartilage. J. Orthop. Res. 11: 479-491
96. 96 Chang S. C., Hoang B., Thomas J. T., Vukicevic S., Luyten F. P., Ryba N. J. et al. (1994) Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J. Biol. Chem. 269: 28227-28234
97. 97 Thomas J. T., Lin K., Nandedkar M., Camargo M., Cervenka J. and Luyten F. P. (1996) A human chondrodysplasia due to a mutation in a TGF-beta superfamily member. Nature Genet. 12: 315-317
98. 98 Thomas J. T., Kilpatrick M. W., Lin K., Erlacher L., Lembessis P., Costa T. et al. (1997) Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nature Genet. 17: 58-64
99. 99 Polinkovsky A., Robin N. H., Thomas J. T., Irons M., Lynn A., Goodman F. R. et al. (1997) Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nature Genet. 17: 18-19
100. 100 Erlacher L., Ng C. K., Ullrich R., Krieger S. and Luyten F. P. (1998) Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arthr. Rheum. 41: 263-273
101. 101 Erlacher L., McCartney J., Piek E., ten Dijke P., Yanagishita M., Oppermann H. et al. (1998) Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. J. Bone Miner. Res. 13: 383-392
102. 102 Dietz, U. H. and Sandell L. J. (1996) Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and during chondrogenesis. J. Biol. Chem. 271: 3311-3316
103. 103 Blesch A., Bosserhoff A. K., Apfel R., Behl C., Hessdoerfer B., Schmitt A. et al. (1994) Cloning of a novel malignant melanoma-derived growth-regulatory protein, M1A. Cancer Res. 54: 5695-5701
104. 104 Bosserhoff A. K., Kondo S., Moser M., Dietz U. H., Copeland N. G., Gilbert D. J. et al. (1997) Mouse CD-RAP, M1A gene: structure, chromosomal localization and expression in cartilage and chondrosarcoma. Dev. Dyn. 208: 516-525
105. 105 Hiraki Y.,Tanaka H., Inoue H., Kondo J., Kamizono A. and Suzuki F. (1991) Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes. Biochem. Biophys. Res. Commun. 175: 971-977
106. 106 Suzuki F., Hiraki Y. and Kato Y. (1987) Preparation of cartilage-derived factor. Methods Enzymol. 146: 313-320
107. 107 Hiraki Y., Inoue H., Iyama K., Kamizono A., Ochiai M., Shukunami C. et al. (1997) Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage. J. Biol. Chem. 272: 32419-32426
108. 108 Shukunami C. and Hiraki Y. (1998 ) Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro. Biochem. Biophys. Res. Commun. 249: 885-890
109. 109 Hiraki Y., Inoue H., Kondo J., Kamizono A., Yoshitake Y., Shukunami C. et al. (1996) A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence. J. Biol. Chem. 271: 22657-22662
110. 110 Mon Y., Hiraki Y., Sluikunami C., Kakudo S., Shiokawa M., Kagoshima M. et al. (1997) Stimulation of osteoblast proliferation by the cartilage-derived growth promoting factors chondromodulin-I and -II. FEBS Lett. 406: 310-314
111. 111 Suzuki F. (1996) Roles of cartilage matrix proteins, chondromodulin-I and -II, in endochondral bone formation: a review. Connect. Tissue Res. 35: 303-307
112. 112 Yamagoe S., Kameoka Y., Hashimoto K., Mizuno S. and Suzuki K. (1998) Molecular cloning, structural charactcrization and chromosomal mapping of the human LECT2 gene. Genomics 48: 324-329
113. 113 Yamagoe S., Akasaka T., Uchida T., Hachiya T., Okabe T., Yamakawa Y. et al. (1997) Expression of a neutrophil chemotactic protein LECT2 in human hepatocytes revealed by immunochemical studies using polyclonal and monoclonal antibodies to a recombinant LECT2. Biochem. Biophys. Res. Comm. 237: 116-120
114. 114 Wagener R., Kobbe B. and Paulsson M. (1997) Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 413: 129-134
115. 115 Wu J. J. and Eyre D. R. (1998) Matrilin-3 forms disulfide-linked oligomers with matrilin-1 in bovine epiphyseal cartilage. J. Biol. Chem. 273: 17433-17438
116. 116 Barone L. M., Owen T. A., Tassinari M. S., Bortell R., Stein G. S. and Lian J. B. (1991) Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis. J. Cell Biochem. 46: 351-365
117. 117 Price P. A. and Williamson M. K. (1985) Primary structure of bovine matrix Gla protein, a new vitamin K-dependent hone protein. J. Biol. Chem. 260; 14971-14975
118. 118 Luo G., D'Souza R., Hogue D. and Karsenty G. (1995) The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. J. Bone Mineral Res. 10: 325-334
119. 119 Luo G., Ducy P., McKee M. D., Pinero G. J., Loyer E., Behringer R. R. et al. (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386: 78-81
120. 120 Milner P. G., Li Y.-S., Hoffman R. M., Kodner C. M., Siegel N. R. and Deuel T. F. (1989) A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence. Biochem. Biophys. Res. Commun. 165: 1096-1103
121. 121 Li Y.-S., Hoffman R. M., Le Beau M. M., Espinosa R., Jenkins N. A., Gilbert D. J. et al. (1992) Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization. J. Biol. Chem. 267: 26011-26016
122. 122 Muramatsu T. (1993) Midkine (MK), the product of a retinoic acid responsive gene, and pleiotrophin constitute a new protein family regulating growth and differentiation. Int. J. Dev. Biol. 37: 183-188
123. 123 Hampton B. S., Marshak D. R. and Burgess W. H. (1992) Structural and functional characterization of full-length heparin-binding growth associated molecule. Mol. Biol. Cell 3: 85-93
124. 124 Choudhuri R., Zhang H., Donnini S., Ziche M. and Bicknell R. (1997) An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res. 57: 1814-1819
125. 125 Dreyfus J., Brunet-de Carvalho N., Duprez D., Raulais D. and Vigny M. (1998) HB-GAM pleiotrophin: localization of mRNA and protein in the chicken developing leg. Int. J. Dev. Biol. 42: 189-198
126. 126 Raulo E., Chernousov M. A., Carey D. J., Nolo R. and Rauvala H. (1994) Isolation of a neuronal cell surface receptor of heparin-binding growth-associated molecule (HB-GAM). J. Biol. Chem. 269: 12999-13004
127. 127 Macda N., Nishiwaki T., Shintani T., Hamanaka H. and Noda M. (1996) 6B4 proteoglycan phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase ξ/RPTPβ, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). J. Biol. Chem. 35: 21446-21452
128. 128 Szabat E. and Rauvala H. (1996) Role of HB-GAM (heparin-binding growth-associated molecule) in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular system. Dev. Biol. 178: 77-89
129. 129 Visser N. A., Vankampen G. F., Dekoning M. H. and Vanderkorst J. K. (1994) Mechanical loading affects the synthesis of decorin and biglycan in intact immature articular cartilage in vitro. Int. J. Tissue React. 16: 195-203
130. 130 Sah R. L., Kim Y. J., Doong J. Y., Grodzinsky A. J., Plaas A. H. and Sandy J. D. (1989) Biosynthetic response of cartilage explants to dynamic compression. J. Orthop. Res. 7: 619-636
131. 131 Gray M. L., Pizzanelli A. M., Grodzinsky A. J. und Lee R. C. (1988) Mechanical and physiochemical determinants of the chondrocyte biosynthetic response. J. Orthop. Res. 6: 777-792
132. 132 Holmvall K., Camper L., Johansson S., Kimura J. H. and Lundgren-Akerlund E. (1995) Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress. Exp. Cell Res. 221: 496-503
133. 133 Muratoglu S., Bachrati C., Malpeli M., Szabo P., Neri M., Dozin B. et al. (1995) Expression of the cartilage matrix protein gene at different chondrocyte developmental stages. Eur. J. Cell Biol. 68: 411-418
134. 134 Xie W. F., Kondo S. and Sandelt L. J. (1998) Regulation of the mouse cartilage-derived retinoic acid-sensitive protein gene by the transcription factor AP-2. J. Biol. Chem. 273: 5026-5032
135. 135 Lanske B. and Kronenberg H. M. (1998) Parathyroid hormone-related peptide (PTHrP) and parathyroid hormone (PTH)/PTHrP receptor. Crit. Rev. Eukaryot Gene. Expr. 8: 297-320
136. 136 Crabb I. D., O'Keefe R. J., Puzas J. E. and Rosier R. N. (1992) Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcif. Tissue Int. 50: 61-66
137. 137 Jobert A. S., Zhang P., Couvineau A., Bonaventure J., Roume J., Le Merrer M. et al. (1998) Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J. Clin, Invest. 102: 34-40
138. 138 Stott N. S. and Chuong C. M. (1997) Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus-mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen. J. Cell Sci. 110: 2691-2701
139. 139 Buckwalter J. A., Ehrlich M. G., Sandell L. J. and Trippel S. B. (eds.) (1998) Skeletal Growth and Development. Clinical Issues and Basic Science Advances, American Academy of Orthopaedic Surgeons, Rosemont, IL
140. 140 Häuselmann H. J., Fernandes R. J., Mok S. S., Schmid T. M., Block J. A., Aydelotte M. B. et al. (1994) Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. J. Cell Sci. 107: 17-27
141. 141 Wright M. O., Nishida K., Bavington C., Godolphin J. L., Dunne E., Walmsley S. et al. (1997) Hyperpolarisation of cultured human chondrocytes following cyclical pressure-induced strain: evidence of a role for alpha 5 beta 1 integrin as a chondrocyte mechanoreceptor. J. Orthop. Res. 15: 742-747