New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4242-4247

  Moss, Neil ^a   Breitfelder, Steffen ^b   Betageri, Raj ^a   Cirillo, Pier F ^a   Fadra, Tazmeen ^a   Hickey, Eugene R ^a   Kirrane, Thomas ^a   Kroe, Rachel R ^a   Madwed, Jeffrey ^a   Nelson, Richard M ^a   Pargellis, Christopher A ^a   Qian, Kevin C ^a   Regan, John ^a   Swinamer, Alan ^a   Torcellini, Carol ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Inhibitor; p38 MAP kinase

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PYRAZOLE NAPHTHYL UREA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; BINDING SITE; COUPLING FACTOR; X RAY CRYSTALLOGRAPHY;

ADENINE; BINDING SITES; HUMANS; MODELS, MOLECULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447092353     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.042     Document Type: Article

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13. a) + 31.2
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15. Experimental details for this model can be found in Ref. 5.
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17. The coordinates of compound 10 bound to p38 have been deposited with the RCSB Protein Data Bank (access code 2PUU).