Anaphylaxis: Can we tell who is at risk of a fatal reaction?

Current Opinion in Allergy and Clinical Immunology

Volumn 4, Issue 4, 2004, Pages 285-290

  Pumphrey, Richard ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Anaphylaxis; Fatal; Iatrogenic; Nut; Sting

Indexed keywords

ACETAZOLAMIDE; ADRENALIN; AMINOPENICILLIN; AMPHOTERICIN; ANESTHETIC AGENT; ANTIBIOTIC AGENT; ATRACURIUM; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; CONTRAST MEDIUM; DIAMORPHINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ETOPOSIDE; FLUORESCEIN; IODINATED CONTRAST MEDIUM; LOCAL ANESTHETIC AGENT; MORPHINE; MUSCLE RELAXANT AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PENICILLIN G; PETHIDINE; PROTAMINE; STREPTOKINASE; SUXAMETHONIUM; TECHNETIUM; UNINDEXED DRUG; VANCOMYCIN; VECURONIUM; VITAMIN K GROUP;

ANAPHYLAXIS; ANESTHESIA; ANGIONEUROTIC EDEMA; ANTIBIOTIC THERAPY; ASTHMA; ATOPY; BANANA; CAUSE OF DEATH; CHICKPEA; CONTRAST RADIOGRAPHY; DRUG HYPERSENSITIVITY; EGG; EMERGENCY TREATMENT; FISH; FOOD ALLERGY; FOOD DRUG INTERACTION; FOOD INTAKE; FRUIT; GEOGRAPHIC DISTRIBUTION; HUMAN; INCIDENCE; INSECT STING; MASTOCYTOSIS; MILK; NUT; PENICILLIN ALLERGY; PRIORITY JOURNAL; RACE DIFFERENCE; RECURRENT DISEASE; REVIEW; RISK FACTOR; SEA FOOD; SELF INJECTION; SEX DIFFERENCE; SHELLFISH; TRACHEOSTOMY; UNITED KINGDOM;

AGE FACTORS; ANAPHYLAXIS; ASTHMA; FOOD HYPERSENSITIVITY; GREAT BRITAIN; HUMANS; INCIDENCE; RECURRENCE; RISK FACTORS; SEX FACTORS; SURVIVAL RATE;

EID: 3442902462     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.all.0000136762.89313.0b     Document Type: Review

References (33)

1. Pumphrey RSH. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000; 30:1144-1150.
2. Pumphrey RSH. Fatal anaphylaxis in the UK, 1992-2001. 2004 Anaphylaxis. Chichester: Wiley (Novartis Foundation Symposium 257); 2004. pp. 116-132. A large population-based study of fatal anaphylaxis with suggestions for improved management.
3. Pumphrey RS, Roberts IS. Postmortem findings after fatal anaphylactic reactions. J Clin Pathol 2000; 53:273-276.
4. Mullins RJ. Anaphylaxis: risk factors for recurrence. Clin Exp Allergy 2003; 33:1033-1040. A useful population-based study of anaphylactic reactions with informative statistics.
5. Yocum MW, Khan DA. Assessment of patients who have experienced anaphylaxis: a 3-year survey. Mayo Clin Proc 1994; 69:16-23.
6. Emmett SE, Angus FJ, Fry JS, Lee PN. Perceived prevalence of peanut allergy in Great Britain and its association with other atopic conditions and with peanut allergy in other household members. Allergy 1999; 54:380-385.
7. Foucard T, Malmheden-Yman I. A study of severe food reactions in Sweden - is soy protein an underestimated cause of food anaphylaxis? Allergy 1999; 54:261-265.
8. Tsevat J, Gross GN, Dowling GP. Fatal asthma after ingestion of sulfite-containing wine. Ann Intern Med 1987; 107:263.
9. Noma T, Yoshizawa I, Ogawa N, et al. Fatal buckwheat dependent exercise-induced anaphylaxis. Asian Pac J Allergy Immunol 2001; 19:283-286.
10. Peng MM, Jick H. A population-based study of the incidence, cause and severity of anaphylaxis in the United Kingdom. Arch Intern Med 2004; 164:317-319.
11. Pumphrey RS, Stanworth SJ. The clinical spectrum of anaphylaxis in northwest England. Clin Exp Allergy 1996; 26:1364-1370.
12. Sheikh A, Alves B. Hospital admissions for acute anaphylaxis: time trend study. BMJ 2000; 320:1441.
13. Sheikh A, Alves B. Age, sex, geographical and socioeconomic variations in admissions for anaphylaxis: analysis of four years of English hospital data. Clin Exp Allergy 2001; 31:1571-1576.
14. Formgren H, Bergstrom SE, Boman G, et al. Can asthma deaths in young people be predicted and prevented? [in Swedish]. Lakartidningen 2001; 98:5314-5315; 5318-5321.
15. Pumphrey RSH. Fatal posture in anaphylactic shock. J Allergy Clin Immunol 2003; 112:451-452. This brief letter suggests a mechanism for pulseless electrical activity and myocardial ischaemia in non-iatrogenic anaphylactic shock.
16. Marone G, de Crescenzo G, Adt M, et al. Immunological characterization and functional importance of human heart mast cells. Immunopharmacology 1995; 31:1-18.
17. Sicherer SH, Furlong TJ, Munoz-Furlong A, et al. A voluntary registry for peanut and tree nut allergy: characteristics of the first 5149 registrants. J Allergy Clin Immunol 2001; 108:128-132.
18. Bock SA, Munoz-Furlong A, Sampson HA, et al. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001; 107:191-193.
19. Lantner R, Reisman RE. Clinical and immunologic features and subsequent course of patients with severe insect-sting anaphylaxis. J Allergy Clin Immunol 1989; 84:900-906.
20. Lenler-Petersen P, Hansen D, Andersen M, et al. Drug-related fatal anaphylactic shock in Denmark 1968-1990. A study based on notifications to the Committee on Adverse Drug Reactions. J Clin Epidemiol 1995; 48:1185-1188.
21. Hermann K, Ring J. The renin-angiotensin system in patients with repeated anaphylactic reactions during hymenoptera venom hyposensitization and sting challenge. J Int Arch Allergy Immunol 1997; 112:251-256.
22. Haeberli G, Bronnimann M, Hunziker T, Muller U. Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy. Clin Exp Allergy 2003; 33:1216-1220.
23. Ober AI, MacLean JA, Hannaway PJ. Life-threatening anaphylaxis to venom immunotherapy in a patient taking an angiotensin-converting enzyme inhibitor. J Allergy Clin Immunol 2003; 112:1008-1009.
24. Bindslev-Jensen C, Briggs D, Osterballe M. Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature? Allergy 2002; 57:741-746. The concept introduced in this paper of a log-normal population distribution of threshold dose for reactions, generally applicable for protein allergens, extending over 5-7 orders of magnitude, is of fundamental importance.
25. Sasvary T, Müller U. Fatalities from insect stings in Switzerland 1978-1987 [in German]. Schweiz Med Wochenschr 1994; 124:1887-1894.
26. Johansson SG, Hourihane JO, Bousquet J, et al. Revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001; 56:813-824.
27. Ludolph-Hauser D, Rueff F, Fries C, et al. Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings. Lancet 2001; 357:361-362.
28. Baldo BA, Pham NH, Zhao Z. Chemistry of drug allergenicity. Curr Opin Allergy Clin Immunol 2001; 1:327-335.
29. Snyder JL, Krishnaswamy G. Autoimmune progesterone dermatitis and its manifestation as anaphylaxis: a case report and literature review. Ann Allergy Asthma Immunol 2003; 90:469-477.
30. Sampson, Mendelson L, Rosen JP, et al. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992; 327:380-384.
31. Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics 1998; 102:6. Available at: http://www.pediatrics.org/cgi/content/full/102/1/e6
32. Vickers DW, Maynard L, Ewan PW. Management of children with potential anaphylactic reactions in the community: a training package and proposal for good practice. Clin Exp Allergy 1997; 27:898-903.
33. Pumphrey RS, Nicholls JM. Epinephrine-resistant food anaphylaxis. Lancet 2000; 355:1099.