Elevated basal serum tryptase and hymenoptera venom allergy: Relation to severity of sting reactions and to safety and efficacy of venom immunotherapy

Clinical and Experimental Allergy

Volumn 33, Issue 9, 2003, Pages 1216-1220

  Haeberli, G ^a   Bronnimann M ^b   Hunziker, T ^b   Muller U ^a,c  

^a Spital Bern Ziegler ^*  (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Spital Bern Ziegler   (Switzerland)

Author keywords

Hymenoptera venom allergy; Immunotherapy; Mastocytosis; Sting challenge; Tryptase

Indexed keywords

HYMENOPTERA VENOM; TRYPTASE; VENOM;

ADOLESCENT; ADULT; AGED; ALLERGIC REACTION; ALLERGY; ANAPHYLACTIC SHOCK; ARTICLE; BEE STING; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; ENZYME ASSAY; ENZYME BLOOD LEVEL; FATALITY; FEMALE; HONEYBEE; HUMAN; IMMUNOTHERAPY; INSECT ALLERGY; INSECT STING; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROVOCATION TEST; RISK FACTOR; SIDE EFFECT; SKIN BIOPSY; TREATMENT OUTCOME; URTICARIA PIGMENTOSA;

ADOLESCENT; ADULT; AGED; ANAPHYLAXIS; ANIMALS; ARTHROPOD VENOMS; BEE VENOMS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; HYMENOPTERA; IMMUNOTHERAPY; INSECT BITES AND STINGS; MALE; MASTOCYTOSIS, CUTANEOUS; MIDDLE AGED; SERINE ENDOPEPTIDASES; TRYPTASES; WASP VENOMS;

EID: 0041735290     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01755.x     Document Type: Article

References (27)

1. Metcalfe DD. Mastocytosis syndromes. In: Middelton E Jr, Reed C, Ellis E, eds. Allergy: principles and practice. St. Louis: Mosby, 1998:1093-1103.
2. Valent P, Escribano L, Parwaresch RM et al. Recent advances in mastocytosis research. Summary of the Vienna Mastocytosis Meeting 1998. Int Arch Allergy Immunol 1999; 120:1-7.
3. Kissling S, Kernland K, Gerbig AW, Hunziker T. Strategies in childhood and adult mastocytosis. Dermatology 1999; 198:426-30.
4. Ispas L, Henriksen RA, Metzger WJ. The many faces of mastocytosis. Ann Allergy Asthma Immunol 2001; 87:6-15.
5. Valent P, Horny HP, Escribano L et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 2001; 25:603-25.
6. Koide T, Nakajima M, Fukuhara N. Systemic mastocytosis and recurrent anaphylactic shock (case report). Lancet 2002; 359:2084.
7. Biedermann T, Rueff F, Sander CA, Przybilla B. Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels. British J Dermatol 1999; 141:1110-2.
8. Fricker M, Helbling A, Schwartz L, Müller U. Hymenoptera sting anaphylaxis and urticaria pigmentosa: clinical findings and results of venom immunotherapy in ten patients. J Allergy Clin Immunol 1997; 100:11-5.
9. Engler RJM, Davis WS. Rush Hymenoptera venom immunotherapy: successful treatment in a patient with systemic mast cell disease. J Allergy Clin Immunol 1994; 94:556-9.
10. Kors JW, vanDoormaal JJ, de Monchy JG. Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis. J Intern Med 1993; 233:255-8.
11. Price LA, Safko MS. Bee venom allergy in a patient with urticaria pigmentosa. J Allergy Clin Immunol 1987; 79:407-9.
12. Müller UR, Horat W, Wüthrich B, Conroy M, Reisman RE. Anaphylaxis after Hymenoptera stings in three patients with urticaria pigmentosa. J Allergy Clin Immunol 1983; 72:685-9.
13. Schwartz LB, Metcalfe DD, Miller JS, Earl H, Sullivan T. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med 1987; 316:1622-6.
14. Schwartz LB, Bradford TR, Rouse C et al. Development of a new, more sensitive Immunoassay for human tryptase: use in systemic anaphylaxis. J Clin Immunol 1994; 14:190-204.
15. Schwartz LB. Tryptase: a clinical indicator of mast cell-dependent events. Allergy Proc 1994; 15:119-23.
16. van der Linden PW, Hack CE, Poortmann J, Vivie-Kipp YC, Struyvenberg A, van der Zwan JK. Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation. J Allergy Clin Immunol 1992; 91:110-8.
17. Ludolph-Hauser D, Ruëff F, Fries C, Schöpf P, Przybilla B. Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings. Lancet 2001; 357:361-2.
18. Mueller HL. Diagnosis and treatment of insect sensitivity. J Asthma Res 1966; 3:331-3.
19. Enrique E, Garcia-Ortega P, Sotorra O, Gaig P, Richart C. Usefulness of Uni-CAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis. Allergy 1999; 54:602-6.
20. Thurnheer U, Müller U, Stoller R, Lanner A, Hoigné R. Venom immunotherapy in Hymenoptera sting allergy. Allergy 1983; 38:465-75.
21. Müller UR, Mosbech H. Position paper: immunotherapy with Hymenoptera venoms. Allergy 1993; 48:37-46.
22. Müller UR, Helbling A, Berchtold E. Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety. J Allergy Clin Immunol 1992; 89:529-35.
23. Kanthawatana S, Carias K, Arnaout R, Hu J, Irani AM, Schwartz LB. The potential clinical utility of serum α-Protryptase levels. J Allergy Clin Immunol 1999; 103:1092-9.
24. Krisha MT, Fearby S, Annila I, Frew A. Hymenoptera stings and serum tryptase. Lancet 2001; 357:1527-8.
25. Oude Elberink JN, de Monchy JG, Kors JW, van Doormaal JJ, Dubois AE. Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis. J Allergy Clin Immunol 1997; 99:153-54.
26. Müller UR, Helbling A, Hunziker T et al. Mastocytosis and atopy: a study of 33 patients with urticaria pigmentosa. Allergy 1990; 45:597-603.
27. Hoffman DR, Jacobson RS. Allergens in Hymenoptera venom XII: How much protein is in a sting? Ann Allergy 1984; 52:276-8.