Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus in response to kainic acid-induced excitotoxicity

Molecules and Cells

Volumn 17, Issue 2, 2004, Pages 292-296

  Choi, Jeong Sun ^a   Kim, Seong Yun ^a   Park, Hyun Jung ^a   Cha, Jung Ho ^a   Choi, Yun Sik ^a   Chung, Jin Woong ^a   Chun, Myung Hoon ^a   Lee, Mun Yong ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

CNTF; CNTFR ; Hippocampus; Kainic acid; Reactive astrocyte

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR; EXCITOTOXIN; KAINIC ACID; MESSENGER RNA; RECEPTOR SUBUNIT; AMINO ACID RECEPTOR STIMULATING AGENT; CONVULSANT AGENT; NEUROTOXIN; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; MALE; NERVE CELL DEGENERATION; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; OBSERVATION; PROTEIN BLOOD LEVEL; RAT; RECEPTOR UPREGULATION; TOXICITY TESTING; ANIMAL; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ASTROCYTES; CILIARY NEUROTROPHIC FACTOR; CONVULSANTS; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; KAINIC ACID; MALE; NEURONS; NEUROTOXINS; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; TIME FACTORS;

EID: 3442880160     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Adler, R., Landa, K. B., Manthorpe, M., and Varon, S. (1979) Cholinergic neurotrophic factors: intraocular distribution of trophic activity for ciliary neurons. Science 204, 1434-1436.
2. Ben-Ari, Y. (1985) Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14, 375-403.
3. Davis, S., Aldrich, T. H., Ip, N. Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P. S., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., and Yancopoulos, G. D. (1993) Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses. Science 259, 1736-1739.
4. Davis, S., Aldrich, T. H., Stahl, N., Pan, L., Taga, T., Kishimoto, T., Ip, N. Y., and Yancopoulos, G. D. (1993) LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 260, 1805-1808.
5. French, S. J., Humby, T., Horner, C. H., Sofroniew, M. V., and Rattray, M. (1999) Hippocampal neurotrophin and trk receptor mRNA levels ae altered by local administration of nicotine, carbachol and pilocarpine. Mol. Brain Res. 67, 124-136.
6. Gearing, D. P., Comeau, M. R., Friend, D. J., Gimpel, S. D., Thut, C. J., McGourty, J., Brasher, K. K., King, J. A., Gillis, S., Mosley, B., Ziegler, S. F., and Cosman, D. (1992) The IL-6 signal transducer, gp130: An oncostatin M receptor and affinity converter for the LIT receptor. Science 255, 1434-1437.
7. Heinrich, P. C., Behrmann, I., Müller-Newen, G., Schaper, F., and Graeve, L. (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 334, 297-314.
8. Ip, N. Y., Nye, S. H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S. J., Yasukawa, K., Kishimoto, T., Anderson, D. J., Stahl, N., and Yancopoulos, G. D. (1992) CNTF and LIF acts on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 69, 1121-1132.
9. Ip, N. Y., McClain, J., Barrezueta, N. X., Aldrich, T. H., Pan, L., Li, Y., Wiegand, S. J., Friedman, B., Davis, S., and Yancopoulos, G. D. (1993a) The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron 10, 89-102.
10. Ip, N. Y., Wiegand, S. J., Morse, J., and Rudge, J. S. (1993b) Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur. J. Neurosci. 5, 25-33.
11. Jankowsky, J. L. and Patterson, P. H. (1999) Differential regulation of cytokine expression following pilocarpine-induced seizure. Exp. Neurol. 159, 333-346.
12. Jankowsky, J. L. and Patterson, P. H. (2001) The role of cytokines and growth factors in seizures and their sequelae. Prog. Neurobiol. 63, 125-149.
13. Katoh-Semba, R., Takeuchi, I. K., Inaguma, Y., Ito, H., and Kato, K. (1999) Brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 in selected regions of the rat brain following kainic acid-induced seizure activity. Neurosci. Res. 35, 19-29.
14. Lee, J.-K., Choi, S.-S., Lee, H.-K., Han K.-J., Han, E.-J., and Suh, H.-W. (2002) Effects of MK-801 and CNQX on various neurotoxic responses induced by kainic acid in mice. Mol. Cells 14, 339-347.
15. Levison, S. W., Ducceschi, M. H., Young, G. M., and Wood, T. L. (1996) Acute exposure to CNTF in vivo induces multiple components of reactive gliosis. Exp. Neurol. 141, 256-268.
16. Manthorpe, M., Louis, J.-L., Hagg, T., and Varon, S. (1993) Ciliary neurotrophic factor; in Neurotrophic factor, Loughlin, S. E. and Fallon, J. H., pp. 443-473, Academic Press, New York,
17. Park, C.-K., Ju, W.-K., Hofmann, H. D., Kirsch, M., Kang, J.-K., Chun, M.-H., and Lee, M.-Y. (2000) Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus following transient global ischemia. Brain Res. 861, 345-353.
18. Rudge, J. S., Pasnikowski, E. M., Holst, P., and Lindsay, R. M. (1995) Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neurons/astrocytes cocultures to kainic acid. J. Neurosci. 15, 6856-6867.
19. Schmidt-Kastner, R., Humpel, C., Wetmore, C., and Olson, L. (1996) Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. Exp. Brain Res. 107, 331-347.
20. Sendtner, M., Carroll, P., Holtmann, B., Hughes, R. A., and Thoenen, H. (1994) Ciliary neurotrophic factor. J. Neurobiol. 25, 1436-1453.
21. Sperk, G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol. 42, 1-32.
22. Taga, T. and Kishimoto, T. (1997) Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797-819.
23. Winter, C. G., Saotome, Y., Levison, S. W., and Hirsh, D. (1995) A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. Proc. Natl. Acad. Sci. USA 92, 5865-5869.
24. Zhang, L., Gelowitz, D. L., Lai, C-T., Boulton, A. A., and Yu, P. H. (1997) Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70. Eur. J. Neurosci. 9, 760-769.