Non-cytolytic antigen clearance in DNA-vaccinated mice with electroporation

Acta Pharmacologica Sinica

Volumn 28, Issue 7, 2007, Pages 1024-1030

  Peng, Jin Liang ^a   Zhao, Yong Gang ^a   Mai, Jun Hua ^a   Pang, Wen Ka ^a   Guo, Wei ^a   Chen, Guang Ming ^b   Mo, Guo Yu ^b   Rao, Guirong ^b   Xu, Yu Hong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b 458 Hospital of People's Liberation Army   (China)

Author keywords

Antigen clearance; DNA vaccine; Electroporation; Hepatitis B virus

Indexed keywords

ALANINE AMINOTRANSFERASE; DNA VACCINE; HEPATITIS B VACCINE; MEMBRANE ANTIGEN; PLASMID VECTOR;

ACTIVE IMMUNIZATION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG DELIVERY SYSTEM; ELECTROPORATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HISTOPATHOLOGY; HYDRODYNAMICS; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, VIRAL; ELECTROPORATION; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HUMANS; LIVER; MICE; MICE, INBRED BALB C; VACCINES, DNA;

EID: 34347391099     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00591.x     Document Type: Article

References (26)

1. World Health Organization Expert Committee on Biological Standardization. Requirements for hepatitis B vaccine. Bull World Health Organ 1988 66 : 443 55.
2. Buendia MA. Hepatitis B viruses and hepatocellular carcinoma. Adv Cancer Res 1992 59 : 167 226.
3. Maupas P, Goudeau A, Coursaget P, Drucker J, Bagros P. Immunization against Hepatitis B in man. Lancet 1976 1 : 1367 70.
4. Vitiello A, Ishioka G, Grey HM, Rose R, Farness P, LaFond R, et al. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. J Clin Invest 1995 95 : 341 9.
5. Thimme R, Chang KM, Pemberton J, Sette A, Chisari FV. Degenerate immunogenicity of an HLA-A2-restricted hepatitis B virus nucleocapsid cytotoxic T lymphocyte epitope that is also presented by HLA-B51. Virology 2001 75 : 3984 7.
6. Wen YM, Wu XH. Hepatitis B vaccine and anti-HBs complex as approach for vaccine therapy. Lancet 1995 345 : 1575 6.
7. Davis HL. DNA vaccines for prophylactic or therapeutic immunization against hepatitis B virus. Mt Sinai J Med 1999 66 : 84 90.
8. Thermet A, Rollier C, Zoulim F, Trepo C, Cova L. Progress in DNA vaccine for prophylaxis and therapy of hepatitis B. Vaccine 2003 21 : 659 62.
9. Sallberg M, Hughes L, Javadian A, Ronlov G, Hultgren C, Townsend K, et al. Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen. Hum Gen Ther 1998 9 : 1719 29.
10. Gregoriadis G, Saffie R, de Souza JB. Liposome-mediated DNA vaccination. FEBS Lett 1997 402 : 107 10.
11. Fuller JT, Fuller DH, McCabe D, Haynes JR, Widera G. Immune responses to hepatitis B virus surface and core antigens in mice, monkeys, and pigs after Accell particle-mediated DNA immunization. Ann NY Acad Sci 1995 772 : 282 4.
12. Selby M, Goldbeck C, Pertile T, Walsh R, Ulmer J. Enhancement of DNA vaccine potency by electroporation in vivo. J Biotechnol 2000 83 : 147 52.
13. Widera G, Austin M, Rabussay D, Goldbeck C, Barnett SW, Chen M, et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 2000 164 : 4635 40.
14. Zhao YG, Peng BW, Deng HW, Chen GM, Yang FQ, Shao M, et al. Anti-HBV immune responses in rhesus macaques elicited by electroporation mediated DNA vaccination. Vaccine 2006 24 : 897 903.
15. Oka Y, Akbar SM, Horiike N, Joko K, Onji M. Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunology 2001 103 : 90 7.
16. Liu F, Song YK, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999 6 : 1258 66.
17. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gen Ther 1999 10 : 1735 7.
18. Tong SP, Li JS, Vitvitski L, Trepo C. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 1990 176 : 596 603.
19. He XQ, Chen GM, Huang Y. Construction and identification of therapeutic double plasmid HBV DNA vaccine. Med J Chin PLA 2003 28 : 493 6.
20. Harty JT, Tvinnereim AR, White DW. CD8 + T cell effector mechanisms in resistance to infection. Annu Rev Immunol 2000 18 : 275 308.
21. Kaech SM, Wherry EJ, Ahmed R. Effector and memory T cell differentiation: implications for vaccine development. Nat Rev Immunol 2002 4 : 251 62.
22. Doolan DL, Hoffman SL. The complexity of protective immunity against liver-stage malaria. J Immunol 2000 165 : 1453 62.
23. Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Schreiber R, Chisari FV. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996 4 : 25 36.
24. Pancholi P, Lee DH, Liu QY, Tackney C, Taylor P, Perkus M, et al. DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee. Hepatology 2001 33 : 448 54.
25. Ketzinel-Gilad M, Zauberman A, Nussbaum O, Shoshany Y, Ben-Moshe O, Pappo O, et al. The use of the hydrodynamic HBV animal model to study HBV biology and anti-viral therapy. Hepatol Res 2006 34 : 228 37.
26. Guidotti LG, Ando K, Hobbs MV, Ishikawa T, Runkel L, Schreiber RD, et al. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci USA 1994 91 : 3764 8.