Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass

European Journal of Cardio-thoracic Surgery

Volumn 32, Issue 2, 2007, Pages 340-345

  Veres, Gábor ^a,b   Radovits, Tamás ^a,b   Schultz, Holger ^a   Lin, Li ni ^a   Hütter, Joachim ^c   Weigang, Ernst ^d   Szabolcs, Zoltán ^b   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c BAYER PHARMA AG   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Aprotinin; Blood loss; Cardiopulmonary bypass; Coronary endothelial function; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; APROTININ; BRADYKININ; HEPARIN; KALLIKREIN; NITROPRUSSIDE SODIUM; RECOMBINANT APROTININ; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; CORONARY BLOOD VESSEL; DOSE RESPONSE; DRUG MECHANISM; NONHUMAN; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROPHYLAXIS; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETYLCHOLINE; ANIMALS; APROTININ; BLOOD COAGULATION; BRADYKININ; CARDIOPULMONARY BYPASS; CATTLE; CORONARY VESSELS; DOGS; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIUM, VASCULAR; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; NITROPRUSSIDE; POSTOPERATIVE HEMORRHAGE; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 34347389194     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2007.02.039     Document Type: Article

References (22)

1. Blauhut B., Gross C., Necek S., Doran J.E., Spath P., and Lundsgaard-Hansen P. Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass. J Thorac Cardiovasc Surg 101 (1991) 958-967
2. Lemmer Jr. J.H., Dilling E.W., Morton J.R., Rich J.B., Robicsek F., Bricker D.L., Hantler C.B., Copeland III J.G., Ochsner J.L., Daily P.O., Whitten C.W., Noon G.P., and Maddi R. Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens. Ann Thorac Surg 62 (1996) 1659-1667
3. Royston D., Bidstrup B.P., Taylor K.M., and Sapsford R.N. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 2 (1987) 1289-1291
4. Murkin J.M., Lux J., Shannon N.A., Guiraudon G.M., Menkis A.H., McKenzie F.N., and Novick R.J. Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations. J Thorac Cardiovasc Surg 107 (1994) 554-561
5. Samama C.M., Langeron O., Rosencher N., Capdevila X., Rouche P., Pegiox M., Berniere J., and Coriat P. Aprotinin versus placebo in major orthopedic surgery: a randomized, double-blinded, dose-ranging study. Anesth Analg 95 (2002) 287-293
6. Patrassi G.M., Viero M., Sartori M.T., De Silvestro G., Rossaros L., Burra P., Nolli M.L., Piccinni P., and Bassi N. Aprotinin efficacy on intraoperative bleeding and transfusion requirements in orthotopic liver transplantation. Transfusion 34 (1994) 507-511
7. Beierlein W., Scheule A.M., Dietrich W., and Ziemer G. Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions. Ann Thorac Surg 79 (2005) 741-748
8. Dietrich W., Spath P., Zuhlsdorf M., Dalichau H., Kirchhoff P.G., Kuppe H., Priess D.U., and Mayer G. Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies. Anesthesiology 95 (2001) 64-71
9. Alderman E.L., Levy J.H., Rich J.B., Nili M., Vidne B., Schaff H., Uretzky G., Pettersson G., Thiis J.J., Hantler C.B., Chaitman B., and Nadel A. Analyses of coronary graft patency after aprotinin use: results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial. J Thorac Cardiovasc Surg 116 (1998) 716-730
10. Kalkat, Levine A., and Dunning J. Does use of aprotinin in coronary artery bypass graft surgery affect graft patency?. Interactive Cardiovasc Thorac Surg 3 (2004) 124-128
11. Bidstrup B.P., Underwood S.R., Sapsford R.N., and Streets R.M. Effect of aprotinin (Trasylol) on aorta-coronary bypass graft patency. J Thorac Cardiovasc Surg 105 (1993) 147-152
12. Khan T.A., Bianchi C., Voisine O., Feng J., Baker J., Hart M., Takahashi M., Stahl G., and Sellke F.W. Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest. J Thorac Cardiovasc Surg 128 (2004) 602-608
13. Ülker S., Cinar M.G., Bayraktutan U., and Evinc A. Aprotinin impairs endothelium-dependent relaxation in rat aorta and inhibits nitric oxide release from rat coronary endothelial cells. Cardiovasc Res 50 (2001) 589-596
14. Ülker S., McKeown P.P., and Bayraktutan U. Aprotinin impairs coronary endothelial function and down-regulates endothelial NOS in rat coronary microvascular endothelial cells. Cardiovasc Res 55 (2002) 830-837
15. Despotis G.J., Filos K.S., Levine V., Alsoufiev A., and Spitznagel E. Aprotinin prolongs activated and nonactivated whole blood clotting time and potentiates the effect of heparin in vitro. Anesth Analg 82 (1996) 1126-1131
16. Wang J.S., Lin C.Y., Hung W.T., Thisted R.A., and Karp R.B. In vitro effects of aprotinin on activated clotting time measured with different activators. J Thorac Cardiovasc Surg 104 (1992) 1135-1140
17. Fischer J.H., and Steinhoff M. Effects of aprotinin on endothelium-dependent relaxation of large coronary arteries. Eur J Cardiothorac Surg 28 (2005) 801-804
18. Allen S., Anastasiou N., Royston D., Paniagua R., and Yacoub M. Effect of aprotinin on vascular reactivity of coronary bypass grafts. J Thorac Cardiovasc Surg 113 (1997) 319-326
19. 2 receptor induce its redistribution on plasma membrane. Int Immunopharmacol 2 (2002) 1795-1806
20. Heaps C.L., Sturek M., Rapps J.A., Laughlin M.H., and Parker J.L. Exercise training restores adenosine-induced relaxation in coronary arteries distal to chronic occlusion. Am J Physiol Heart Circ Physiol 278 (2000) 1984-1992
21. Arif Hasan A.Z., Abebe W., and Mustafa S.J. Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385. Cardiovasc Pharmacol 35 (2000) 322-325
22. Lynch F.M., Austin C., Heagerty A.M., and Izzard A.S. Adenosine and hypoxic dilation of rat coronary small arteries: roles of the ATP-sensitive potassium channel, endothelium, and nitric oxide. Am J Physiol Heart Circ Physiol 290 (2006) 1145-1150