Coexpression odf Wilms' tumor suprresor 1 (WT1) and androgen receptor (AR) in the genital tract of human male embryos and regulation of AR promoter activity by WT1

Journal of Molecular Endocrinology

Volumn 38, Issue 5-6, 2007, Pages 547-554

  Köhler, Birgit ^d,e   Delezoide, Anne Lise ^a   Boizet Bonhoure, Brigitte ^b   McPhaul, Michael J ^c   Sultan, Charles ^d   Lumbroso, Serge ^d,f  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b INSTITUTE OF HUMAN GENETICS   (France)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d MONTPELLIER UNIVERSITY HOSPITAL   (France)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f DEPARTMENT OF NEUROLOGY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; WT1 PROTEIN; AR PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EPIDIDYMIS; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MALE GENITAL SYSTEM; MESENCHYME; MESONEPHROS; MUELLERIAN DUCT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; TESTIS; UROGENITAL SINUS; UROGENITAL SYSTEM; VAS DEFERENS; WILD TYPE; ANIMAL; CELL CULTURE; CERCOPITHECUS; GENETICS; HELA CELL; METABOLISM; PRENATAL DEVELOPMENT;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENITALIA, MALE; HELA CELLS; HUMANS; MALE; PROMOTER REGIONS (GENETICS); RECEPTORS, ANDROGEN; WT1 PROTEINS;

EID: 34347384181     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/JME-06-0020     Document Type: Article

References (33)

1. Adachi M, Takayanagi R, Tomura A, Imasaki K, Kato S, Goto K, Yanase T, Ikuyama S & Nawata H 2000 Androgen-insensitivity syndrome as a possible coactivator disease. New England Journal of Medicine 343 856-862.
2. Auber F, Lortat-Jacob S, Sarnacki S, Jaubert F, Salomon R, Thibaud E, Jeanpierre C & Nihoul-Fekete C 2003 Surgical management and genotype/ phenotype correlations in WT1 gene-related diseases (Drash, Frasier syndromes). Journal of Pediatric Surgery 38 124-129 discussion 124-129.
3. Barbaux S, Niaudet P, Gubler MC, Grunfeld JP, Jaubert F, Kuttenn F, Fekete CN, Souleyreau-Therville N, Thibaud E, Fellous M et al. 1997 Donor splice-site mutations in WT1 are responsible for Frasier syndrome. Nature Genetics 17 467-470.
4. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH et al. 1990 Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60 509-520.
5. Deeb A, Mason C, Lee YS & Hughes IA 2005 Correlation between genotype, phenotype and sex of rearing in 111 patients with partial androgen insensitivity syndrome. Clinical Endocrinology 63 56-62.
6. Gassler M, Poustka A, Cavenee W, Neve RL, Orkin SH & Bruns GA 1990 Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343 774-778.
7. Ghali SA, Gottlieb B, Lumbroso R, Beitel LK, Elhaji Y, Wu J, Pinsky L & Trifiro MA 2003 The use of androgen receptor amino/ carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivity. Journal of Clinical Endocrinology and Metabolism 88 2185-2193.
8. Goodman FR, Bacchelli C, Brady AF, Brueton LA, Fryns JP, Mortlock DP, Innis JW, Holmes LB, Donnenfeld AE, Feingold M et al. 2000 Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome. American Journal of Human Genetics 67 197-202.
9. Hastie ND 2001 Life, sex, and WT1 isoforms - three amino acids can make all the difference. Cell 106 391-394.
10. Hossain A & Saunders GF 2001 The human sex-determining gene SRY is a direct target of WT1. Journal of Biological Chemistry 276 16817-16823.
11. Jeanpierre C, Beroud C, Niaudet P & Junien C 1998 Software and database for the analysis of mutations in the human WT1 gene. Nucleic Acids Research 26 271-274.
12. Kim J, Prawitt D, Bardeesy N, Torban E, Vicaner C, Goodyer P, Zahel B & Pelletier J 1999 The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation. Molecular and Cellular Biology 19 2289-2299.
13. Kohler B, Schumacher V, l'Allemand D, Royer-Pokora B & Gruters A 2001 Germline Wilms tumor suppressor gene (WT1) mutation leading to isolated genital malformation without Wilms tumor or nephropathy. Journal of Pediatrics 138 421-424.
14. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D & Jaenisch R 1993 WT-1 is required for early kidney development. Cell 74 679-691.
15. Lim HN, Hughes IA & Hawkins JR 2001 Clinical and molecular evidence for the role of androgens and WT1 in testis descent. Molecular and Cellular Endocrinology 185 43-50.
16. Little M & Wells C 1997 A clinical overview of WT1 gene mutations. Human Mutation 9 209-225.
17. Little M, Holmes G, Bickmore W, van Heyningen V, Hastie N & Wainwright B 1995 DNA binding capacity of the WT1 protein is abolished by Denys-Drash syndrome WT1 point mutations. Human Molecular Genetics 4 351-358.
18. Melo KF, Martin RM, Costa EM, Carvalho FM, Jorge AA, Arnhold IJ & Mendonca BB 2002 An unusual phenotype of Frasier syndrome due to IVS9+4C>T mutation in the WT1 gene: predominantly male ambiguous genitalia and absence of gonadal dysgenesis, Journal of Clinical Endocrinology and Metabolism 87 2500-2505.
19. Menke AL, van der Eb AJ & Jochemsen AG 1998 The Wilms' tumor 1 gene: oncogene or tumor suppressor gene? International Review of Cytology 181 151-212.
20. Morgan EA, Nguyen SB, Scott V & Stadler HS 2003 Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development 130 3095-3109.
21. Mortlock DP & Innis JW 1997 Mutation of HOXA13 in hand-foot-genital syndrome. Nature Genetics 15 179-180.
22. Nachtigal MW, Hirokawa Y, Enyeart-VanHouten DL, Flanagan JN, Hammer GD & Ingraham HA 1998 Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell 93 445-454.
23. Natoli TA, McDonald A, Alberta JA, Taglienti ME, Housman DE & Kreidberg JA 2002 A mammal-specific exon of WT1 is not required for development or fertility. Molecular and Cellular Biology 22 4433-4438.
24. Pelletier J, Bruening W, Kashtan CE, Mauer SM, Manivel JC, Striegel JE, Houghton DC, Junien C, Habib R & Fouser L 1991 Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 67 437-447.
25. Reddy JC, Hosono S & Licht JD 1995 The transcriptional effect of WT1 is modulated by choice of expression vector. Journal of Biological Chemistry 270 29976-29982.
26. Roberts LM, Hirokawa Y, Nachtigal MW & Ingraham HA 1999 Paracrine-mediated apoptosis in reproductive tract development. Developmental Biology 208 110-122.
27. Scharnhorst V, van der Eb AJ & Jochemsen AG 2001 WT1 proteins: functions in growth and differentiation. Gene 273 141-161.
28. Shimamura R, Fraizer GC, Trapman J, Lau YFC & Saunders GF 1997 The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Mullerian-inhibiting substance, and the androgen receptor. Clinical Cancer Research 3 2571-2580.
29. Teixeira J, Maheswaran S & Donahoe PK 2001 Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. Endocrine Reviews 22 657-674.
30. Umar A, Bearevoets CA, Van NM, van Leeuwen M, Verbiest M, Kleijer WJ, Dooijes D, Grootegoed JA, Drop SL & Brinkmann AO 2005 Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity. Journal of Clinical Endocrinology and Metabolism 90 507-515.
31. Wagner KD, Wagner N & Schedl A 2003 The complex life of WT1. Journal of Cell Science 116 1653-1658.
32. Wilhelm D & Englert C 2002 The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1. Genes and Development 16 1839-1851.
33. Yamada G, Suzuki K, Haraguchi R, Miyagawa S, Satoh Y, Kamimura M, Nakagata N, Kataoka H, Kuroiwa A & Chen Y 2006 Molecular genetic cascades for external genitalia formation: an emerging organogenesis program. Developmental Dynamics 235 1738-1752.