The role of NF-κB in hepatocarcinogenesis: Promoter or suppressor?

Journal of Hepatology

Volumn 47, Issue 2, 2007, Pages 307-309

  Seki, Ekihiro ^a   Brenner, David A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; CANCER INHIBITION; CHRONIC LIVER DISEASE; HUMAN; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER PARENCHYMA; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 34347377864     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.05.006     Document Type: Article

References (7)

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3. Karin M. NF-κB and cancer: mechanisms and targets. Mol Carcinog 45 (2006) 355-361
4. Maeda S., Kamata H., Luo J.L., Leffert H., and Karin M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121 (2005) 977-990
5. Sakurai T., Maeda S., Chang L., and Karin M. Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci USA 103 (2006) 10544-10551
6. Luedde T., Beraza N., Kotsikoris V., van Loo G., Nenci A., De Vos R., et al. Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 11 (2007) 119-132
7. Nenci A., Becker C., Wullaert A., Gareus R., van Loo G., Danese S., et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446 (2007) 557-561