Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(β -aminoester)-graft-PEG for cancer chemotherapy

Drug Delivery

Volumn 14, Issue 5, 2007, Pages 279-286

  Jin, Wei ^a,b   Xu, Peisheng ^a   Zhan, Yihong ^a   Shen, Youqing ^a   Van Kirk, Edward A ^c   Alexander, Brenda ^c   Murdoch, William J ^c   Liu, Lijian ^b   Isaak, Dale D ^c  

^a UNIVERSITY OF WYOMING   (United States)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF WYOMING   (United States)

Author keywords

Cancer Chemotherapy; Cisplatin; Degradable Polyesters; Nanogel

Indexed keywords

CARBOXYLIC ACID; CISPLATIN; COPOLYMER; ESTER DERIVATIVE; MACROGOL; NANOPARTICLE; PIPERAZINE; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; GEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OVARY CANCER; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; SURFACE CHARGE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; ESTERS; FEMALE; HUMANS; MALE; MICE; MICE, NUDE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OVARIAN NEOPLASMS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; SOLUBILITY; TIME FACTORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34347373854     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540601036856     Document Type: Article

References (41)

1. Akinc, A., Anderson, D. G., Lynn, D. M., and Langer, R. 2003. Synthesis of poly(β-amino ester)s optimized for highly effective gene delivery. Bioconjugate Chem. 14:979-988.
2. Anderson, D. G., Lynn, D. M., and Langer, R. 2003. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew. Chem. Int. Ed. 42:3153-3158.
3. Aronov, O., Horowitz, A. T., Gabizon, A., Fuertes, M. A., Perez, J. M., and Gibson, D. 2004. Nuclear localization signal-targeted poly(ethylene glycol) conjugates as potential carriers and nuclear localizing agents for carboplatin analogues. Bioconjugate Chem. 15:814-823.
4. Avichechter, D., Schechter, B., and Arnon, R. 1998. Functional polymers in drug delivery: carrier-supported CDDP (cis-platin) complexes of polycarboxylates - effect on human ovarian carcinoma. React. Funct. Polym. 36:59-69.
5. Bogdanov, Jr. A. A., Martin, C., Bogdanova, A. V., Brady, T. J., and Weissleder, R. 1996. An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: Synthesis and cytotoxic properties. Bioconjugate Chem. 7:144-149.
6. Cabral, H., Nishiyama, N., Okazaki, S., Koyama, H., and Kataoka, K. 2005. Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum(II) (DACHPt)-loaded polymeric micelles. J. Control. Rel. 101:223-232.
7. Fuertes, M. A., Alonso, C., and Perez, J. M. 2003. Biochemical modulation of cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance. Chem. Rev. 103:645-662.
8. Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., and Leroux, J.-C. 2005. Block copolymer micelles: preparation, characterization and application in drug delivery. J. Control. Rel. 109:169-188.
9. Gianasi, E., Wasil, M., Evagarou, E. G., Keddle, A., Wilson, G., and Duncan, D. 1999. HPMA copolymer platinates as novel antitumor agents: in vitro properties, pharmacokinetics and antitumor activity in vivo. Eur. J. Cancer 35:994-1002.
10. Gillies, E. R., and Frechet, J. M. J. 2005. Dendrimers and dendritic polymers in drug delivery. Drug Discov. Today 10:35-43.
11. Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., and Jain, R. K. 1998. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. USA 95:4607-4612.
12. Kwon, G. S. 2003. Polymeric micelles for delivery of poorly water-soluble compounds. Crit. Rev. Therap. Drug Carrier Syst. 20:357-403.
13. Lajer, H., and Daugaard, G. 1999. Cisplatin and hypomagnesemia. Cancer Treat. Rev. 25:47-58.
14. Lee, C. M., Tanaka, T., Murai, T., Kondo, M. K., J., Su, W., Kitagawa, T., Ito T., Matsuda, H., and Miyasaka, M. 2002. Novel condroitin sulfatebinding cationic liposomes loaded with cisplatin efficiently supress the local growth and liver metastasis of tumor cells in vivo. Cancer Res. 62:4282-4288.
15. Lin, X., Zhang, Q., Rice, J. R., Stewart, D. R., Nowotnik, D. P., and Howell, S. B. 2004. Improved targeting of platinum chemotherapeutics: the antitumour activity of the HPMA copolymer platinum agent AP5280 in murine tumour models. Eur. J. Cancer 40:291-297.
16. Linuma, H., Maruyama, K., Okinaga, K., Sasaki, K., Sekine, T., Ishida, O., Ogiwara, N., Johkura, K., and Yonemura, Y. 2002. Intracellular targeting therapy of cisplatin-encapsulated transferrin-polyethylene glycol liposome on peritoneal dissemination of gastric cancer. Int. J. Cancer 99: 130-137.
17. Little, S. R., Lynn, D. M., Ge, Q., Anderson, D. G., Puram, S. V., Chen, J., Eisen, H. N., and Langer, R. 2004. Poly-b-amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc. Natl. Acad. Sci. USA 101:9534-9539.
18. Little, S. R., Lynn, D. M., Puram, S. V., and Langer, R. 2005. Formulation and characterization of poly (b-amino ester) microparticles for genetic vaccine delivery. J. Control. Rel. 107:449-462.
19. Maeda, H., Fang, J., Inutsuka, T., and Kitamoto, Y. 2003. Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications. Int. Immunopharmacol. 3:319-328.
20. Malik, N., Evagorou, E. G., and Duncan, R. 1999. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs 10:767-776.
21. McKeage, M. J. 2005. New-generation platinum drugs in the treatment of cisplatin-resistant cancers. Expert Opin. Invest. Drugs 14:1033-1046.
22. Molineux, G. 2002. Pegylation: engineering improved pharmaceuticals for enhanced therapy. Cancer Treat. Rev. 28:13-16 (suppl).
23. Newman, M. S., Colbern, G. T., Working, P. K., Engbers, C., and Amantea, M. A. 1999. Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long circulating, pegylated liposomes (SPI-077) in tumorbearing mice. Cancer Chemother. Pharmacol. 43:1-7.
24. Nishiyama, N., Koizumi, F., Okazaki, S., Matsumura, Y., Nishio, K., and Kataoka, K. 2003a. Differential gene expression profile between PC-14 cells treated with freecisplatin and cisplatin-incorporated polymeric micelles. Bioconjugate Chem. 14:449-457.
25. Nishiyama, N., Okazaki, S., Cabral, H., Miyamoto, M., Kato, Y., Sugiyama, Y., Nishio, K., Matsumura, Y., and Kataoka, K. 2003b. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res. 63:8977-8983.
26. Nishiyama, N., Yokoyama, M., Aoyagi, T., Okano, T., Sakurai, Y., and Kataoka, K. 1999. Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(aspartic acid) block copolymer in an aqueous medium. Langmuir 15:377-383.
27. Perez, R. P. 1998. Cellular and molecular determinants of cisplatin resistance. Eur. J. Cancer 34:1535-1542.
28. Pinzani, V., Bressolle, F., Hang, I. J., Galtier, M., Blayac, J. P., and Balmes, P. 1994. Cisplatin-induced renal toxicity and toxicity-modulating strategies: a review. Cancer Chemother. Pharmacol. 35:1-9.
29. Rademaker-Lakhai, J. M., Terret, C., Howell, S. B., Baud, C. M., de Boer, R. F., Pluim, D., Beijnen, J. H., Schellens, J. H. M., and Droz, J.-P. 2004. A phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors. Clin. Cancer Res. 10:3386-3395.
30. Rosenberg, B., VanCamp, L., Trosko, J. E., and Mansour, V. H. 1969. Platinum compounds: a new class of potent antitumor agents. Nature 222:385-386.
31. Senter, P. D., and Kopecek, J. 2004. Drug carriers in medicine and biology. Mol. Pharm. 1:395-398.
32. Shenoy, D., Little, S., Langer, R., and Amiji, M. 2005. Poly(ethylene oxide)-modified poly(b-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Mol. Pharm. 2:357-366.
33. Song, R., Jun,Y. J., Kim, J. I., Jin, C., and Sohn,Y. S. 2005. Synthesis, characterization, and tumor selectivity of a polyphosphazene-platinum(II) conjugate. J. Control. Rel. 105 142-150.
34. Torchilin, V. P. 2005. Recent advances with liposomes as pharmaceutical carriers. Nature Rev. Drug Discov. 4:145-160.
35. Unezaki, S., Maruyama, K., Hosoda, J.-I., Nagae, I., Koyanagi, Y., Nakata, M., Ishida, O., Iwatsuru, M., and Tsuchiya, S. 1996. Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy. Int. J. Pharm. 144:11-17.
36. Vicent, M. J., and Duncan, R. 2006. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechn. 24:39-47.
37. Wong, E., and Giandomenico, C. M. 1999. Current status of platinum-based antitumor drugs. Chem. Rev. 99:2451-2466.
38. Xu, P., Li, S.-Y., Li, Q., Ren, J., Van Kirk, E. A., Murdoch, W. J., Radosz, M., and Shen, Y. 2006a. Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes. Biotech. Bioeng. 95:893-903.
39. Xu, P., Van Kirk, E. A., Li, S.-Y., Murdoch, W. J., Ren, J., Hussain, M. D., Radosz, M., and Shen, Y. 2006b. Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloi. Surf.B: Biointerf. 48:50-57.
40. Xu, P., Van Kirk, E. A., Murdoch, W. J., Zhan, Y., Isaak, D. D., Radosz, M., and ShenY. 2006c. Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules 7:829-835.
41. Yuan, F., Dellian, M., Fukumura, D., Leuning, M., Berk, D. D., Torchilin, V. P., and Jain, R. K. 1995. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 55: 3752-3756.