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For Pd-catalyzed oxidative synthesis of pyrazino[1,2-a]indoles and pyrrolo[1,2-a]pyrazinones, see: a) G. Abbiati, E. M. Beccalli, G. Broggini, C. Zoni, J. Org. Chem. 2003, 68, 7625-7628;
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This network of interactions has been recognized also to be fundamental in the pharmaceutical activity of structural analogous non-peptidic HLE inhibitors: C. A. Veale Jr, J. R. Damewood, G. B. Steelman, C. Bryant, B. Gomes, J. Williams, J. Med. Chem. 1995, 38, 86-97
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This network of interactions has been recognized also to be fundamental in the pharmaceutical activity of structural analogous non-peptidic HLE inhibitors: C. A. Veale Jr, J. R. Damewood, G. B. Steelman, C. Bryant, B. Gomes, J. Williams, J. Med. Chem. 1995, 38, 86-97.
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16
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3): δ = 9.6 (N1-H) ppm (c.f. unsubstituted indoles: δ = 8.2-8.4 ppm).
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3): δ = 9.6 (N1-H) ppm (c.f. unsubstituted indoles: δ = 8.2-8.4 ppm).
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