An efficient synthesis of novel heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine using Ugi condensation

Tetrahedron Letters

Volumn 46, Issue 5, 2005, Pages 881-884

  Ilyn, Alexey P ^a   Kuzovkova, Julia A ^a   Potapov, Victor V ^a   Shkirando, Alexandre M ^a   Kovrigin, Denis I ^a   Tkachenko, Sergey E ^b   Ivachtchenko, Alexandre V ^b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

3,4 Dihydropyrazino 1,2 a indol 1(2H) one; 3,4 Dihydropyrrolo 1,2 a pyrazin 1(2H) one; Library; Ugi condensation

Indexed keywords

1 OXO 1,2,3,4 TETRAHYDROPYRAZINE; INDOLE; PYRAZINE DERIVATIVE; PYRROLE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 11844290691     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.11.168     Document Type: Article

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23. 2) 6.4 (d, 1H, J = 8.2 Hz, ArH), 6.47 (2d, 1H, J = 8.4Hz, ArH), 6.52 (d, 1H, J = 8.1 Hz, ArH), 6.74 (d, 1H, J = 8.1 Hz, ArH), 7.2-7.36 (m, 4H, ArH), 7.6 (d, 1H, J = 8.2 Hz, ArH); HRMS m/z 454.1891 (M+)