Effects of the anticancer dehydrotarplatin on cytochrome P450 and antioxidant enzymes in male rat tissues

Archives of Toxicology

Volumn 81, Issue 7, 2007, Pages 479-487

  Nannelli, Annalisa ^a   Messina, Andrea ^a   Marini, Sandra ^b   Trasciatti, Silvia ^b   Longo, Vincenzo ^a   Gervasi, Pier Giovanni ^a  

^a CNR   (Italy)

^b Abiogen Pharma SpA   (Italy)

Author keywords

Dehydrotarplatin; Hepatic, renal and testicular P450; Oxidative stress enzymes

Indexed keywords

16ALPHA TESTOSTERONE HYDROXYLASE; 17ALPHA PROGESTERONE HYDROXYLASE; 2ALPHA TESTOSTERONE HYDROXYLASE; ANTIBODY; ANTINEOPLASTIC AGENT; APOPROTEIN; CATALASE; CISPLATIN; CREATININE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; DEHYDROTARPLATIN; DRUG METABOLITE; ENZYME; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LAURATE HYDROXYLASE; NITROGEN; SUPEROXIDE DISMUTASE; TESTOSTERONE; TRIACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMINIZATION; KIDNEY; LIPID PEROXIDATION; LIVER; LIVER WEIGHT; LOW DRUG DOSE; MALE; MICROSOME; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BLOOD UREA NITROGEN; BODY WEIGHT; CREATININE; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; ISOENZYMES; KIDNEY; LAURIC ACIDS; LIVER; MALE; MICROSOMES; ORGAN SIZE; ORGANOPLATINUM COMPOUNDS; OXIDATIVE STRESS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY; TESTIS; TESTOSTERONE;

RATTUS;

EID: 34347325111     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0184-7     Document Type: Article

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