LipoCardium: Endothelium-directed cyclopentenone prostaglandin-based liposome formulation that completely reverses atherosclerotic lesions

Atherosclerosis

Volumn 193, Issue 2, 2007, Pages 245-258

  Homem de Bittencourt Jr , Paulo I ^a   Lagranha, Denise J ^a   Maslinkiewicz, Alexandre ^a   Senna, Sueli M ^a,b   Tavares, Angela M V ^a   Baldissera, Lisiane P ^a   Janner, Daiane R ^a   Peralta, Joelso S ^a   Bock, Patrícia M ^a   Gutierrez, Lucila L P ^a   Scola, Gustavo ^a   Heck, Thiago G ^a   Krause, Maurício S ^a   Cruz, Lavínia A ^a,b   Abdalla, Dulcinéia S P ^b   Lagranha, Cláudia J ^b   Lima, Thais ^b   Curi, Rui ^b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adhesion molecules; Atherosclerosis; Cyclopentenone prostaglandins; Endothelium; Leukocytes; Lipid metabolism; Macrophages

Indexed keywords

ANTIBODY; CYCLOPENTENONE; HEAT SHOCK PROTEIN; LIPOCARDIUM; LIPOSOME; LOW DENSITY LIPOPROTEIN; PROSTAGLANDIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTERY WALL; ARTICLE; ATHEROSCLEROSIS; BLOOD FLOW; DRUG FORMULATION; ENDOTHELIUM; ENDOTHELIUM CELL; IN VITRO STUDY; INFLAMMATION; LIPID DIET; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ATHEROSCLEROSIS; CYCLOPENTANES; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; LIPID METABOLISM; LIPOSOMES; MACROPHAGES; MALE; MICE; PROSTAGLANDINS; PROSTAGLANDINS A; RATS; RATS, WISTAR;

EID: 34347262128     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.08.049     Document Type: Article

References (47)

1. Ross R., and Glomset J.A. Atherosclerosis and the arterial smooth muscle cell: proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science 180 (1973) 1332-1339
2. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
3. Libby P., Ridker P.M., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
4. Blankenberg S., Barbaux S., and Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis 170 (2003) 191-203
5. 2+ channel blockers. Atherosclerosis 88 (1991) 109-132
6. Choudhury R.P., Lee J.M., and Greaves D.R. Mechanisms of disease: macrophage-derived foam cells emerging as therapeutic targets in atherosclerosis. Nat Clin Pract Cardiovasc Med 2 (2005) 309-315
7. Brown M.S., Ho Y.K., and Goldstein J.L. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. J Biol Chem 255 (1980) 9344-9352
8. Sunderkötter C., Steinbrink K., Goebeler M., Bhardwaj R., and Sorg C. Macrophages and angiogenesis. J Leukoc Biol 55 (1994) 410-422
9. Rosenfeld M.E., Khoo J.C., Miller E., et al. Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesion degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts. J Clin Invest 87 (1991) 90-99
10. Frostegård J., Nilsson J., Haegerstrand A., et al. Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. Proc Natl Acad Sci USA 87 (1990) 904-908
11. Frostegård J., Wu R., Haegerstrand A., et al. Mononuclear leukocytes exposed to oxidized low density liprotein secrete a factor that stimulates endothelial cells to express adhesion molecules. Atherosclerosis 103 (1993) 213-219
12. Collins T., Read M.A., Neish A.S., et al. Transcriptional regulation of endothelial cell adhesion molecules: NF-B and cytokine-inducible enhancers. FASEB J 9 (1995) 899-909
13. Griendling K.K., and Alexander R.W. Endothelial control of the cardiovascular system: recent advances. FASEB J 10 (1996) 283-292
14. Moynagh P.N. The NF-κB pathway. J Cell Sci 118 (2005) 4589-4592
15. Tedder T.F., Steeber D.A., Chen A., and Engel P. The selectins: vascular adhesion molecules. FASEB J 9 (1995) 866-873
16. Nakashima Y., Raines E.W., Plump A.S., Breslow J.L., and Ross R. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in ApoE-deficient mouse. Arterioscler Thromb Vasc Biol 18 (1998) 842-851
17. Amin M.A., Haas C.S., Zhu K., et al. Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFκB. Blood 107 (2006) 2252-2261
18. Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 82 (2002) 47-95
19. Kokura S., Wolf R.E., Yoshikawa T., Granger D.N., and Aw T.Y. Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance. Circ Res 84 (1999) 516-524
20. 1: an effect associated with heat shock transcription factor activation. Proc Natl Acad Sci USA 94 (1997) 746-750
21. Homem de Bittencourt Jr. P.I., and Curi R. Antiproliferative prostaglandins and MRP/GS-X pump: role in cancer immunosuppression and insight into new strategies in cancer gene therapy. Biochem Pharmacol 62 (2001) 811-819
22. Rossi A., Kapahi P., Natoli G., et al. Antiinflammatory cyclopentenone prostaglandins are direct inhibitors of Iκ-B kinase. Nature 403 (2000) 103-108
23. Morimoto R.I., and Santoro M.G. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol 16 (1998) 833-838
24. Santoro M.G. Heat shock factors and the control of the stress response. Biochem Pharmacol 59 (2000) 55-63
25. Senna S.M., Moraes R.B., Bravo M.F.R., et al. Effects of prostaglandins and nitric oxide on rat macrophage lipid metabolism in culture: implications for arterial wall-leukocyte interplay in atherosclerosis. Biochem Mol Biol Int 46 (1998) 1007-1018
26. Homem de Bittencourt Jr. P.I., and Curi R. Transfer of cholesterol from macrophages to lymphocytes in culture. Biochem Mol Biol Int 44 (1998) 347-362
27. Kohno H., Sueshige N., Oguri K., et al. Simple and practical sandwich-type enzyme immunoassay for human oxidatively modified low density lipoprotein using antioxidized phosphatidylcholine monoclonal antibody and antihuman apolipoprotein-B antibody. Clin Biochem 33 (2000) 243-253
28. Hodis H.N., Kramsch D.M., Avogaro P., et al. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). J Lipid Res 35 (1994) 669-677
29. Draper H.H., Squires E.J., Mahmoodi H., et al. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Rad Biol Med 15 (1993) 353-363
30. Hurst J.S., Flatman S., and McDonald-Gibson R.G. Thin-layer chromatography (including radio thin-layer chromatography) of prostaglandins and related compounds. In: Benedetto C., McDonald-Gibson R.G., Nigan S.N., and Slater T.F. (Eds). Prostaglandins and related substances-a practical approach (1987), IRL, Oxford 53-73
31. Powell W.S. High pressure liquid chromatography in the analysis of arachidonic acid metabolites. In: Benedetto C., McDonald-Gibson R.G., Nigan S.N., and Slater T.F. (Eds). Prostaglandins and related substances-a practical approach (1987), IRL, Oxford 75-98
32. Cury-Boaventura M.F., Pompeia C., and Curi R. Comparative toxicity of oleic acid and linoleic acid on Jurkat cells. Clin Nutr 23 (2004) 721-732
33. Kolberg A., Rosa T.G., Puhl M.T., et al. Low expression of MRP/GS-X pump ATPase in lymphocytes of Walker 256 tumor-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency. Cell Biochem Funct 24 (2006) 23-39
34. Lillie R.D. Histopathologic Technic and Practical Histochemistry. 3rd ed. (1965), McGraw-Hill Book Co., New York 715 pp
35. Pearse A.G.E. Histochemistry: theoretical and applied (1968), Churchill Livingstone, Edinburg p. 399-442
36. Goldstein J.L., and Brown M.S. Regulation of the mevalonate pathway. Nature 343 (1990) 425-430
37. Tsiara S., Elisaf M., and Mikhailidis D.P. Early vascular benefits of statin therapy. Curr Med Res Opin 19 (2003) 540-546
38. Pereira E.C., Bertolami M.C., Faludi A.A., Sevanian A., and Abdalla D.S.P. Antioxidant effect of simvastatin is not enhanced by its association with α-tocopherol in hypercholesterolemic patients. Free Rad Biol Med 37 (2004) 1440-1448
39. Han J., Hajjar D.P., Tauras J.M., and Nicholson A.C. Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36. J Lipid Res 40 (1999) 830-838
40. Nicholson A.C., and Hajjar D.P. CD36, oxidized LDL and PPAR gamma: pathological interactions in macrophages and atherosclerosis. Vascul Pharmacol 41 (2005) 139-146
41. Saxena U., Ferguson E., and Newton R.S. Acyl-coenzyme A: cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells. Atherosclerosis 112 (1995) 7-17
42. Kusunoki J., Hansoty D.K., Aragane K., et al. Acyl-CoA: cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 103 (2001) 2604-2609
43. Ianaro A., Maffia P., Cuzzocrea S., et al. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-κB. FEBS Lett 553 (2003) 21-27
44. Saxena A., McMeekin J.D., and Thomson D.J. Expression of Bcl-x, Bcl-2, Bax, and Bak in endarterectomy and atherectomy specimens. J Pathol 196 (2002) 335-342
45. Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol 25 (2005) 2255-2264
46. 2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-κB activity and down-regulation of antiapoptotic proteins. Blood 105 (2005) 1750-1758
47. Xu Q. Role of heat shock proteins in atherosclerosis. Arterioscl Thromb Vasc Biol 22 (2002) 1547-1559