Dehydroepiandrosterone, the endothelium, and cardiovascular protection

Endocrinology

Volumn 148, Issue 7, 2007, Pages 3065-3067

  Simoncini, Tommaso ^a   Genazzani, Andrea R ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE;

ENDOTHELIUM; HEART PROTECTION; PRIORITY JOURNAL; SHORT SURVEY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CATTLE; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; ENDOTHELIAL CELLS; HUMANS; MODELS, BIOLOGICAL; NITRIC OXIDE SYNTHASE TYPE III; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 34347235832     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0424     Document Type: Short Survey

References (28)

1. Baulieu E-E, Corpechot C, Dray F, Emiliozzi R, Lebeau M-C, Mauvais-Jarvis P, Robel P 1965 An adrenal secreted androgen: dehydroepiandrosterone sulfate. Its metabolism and a tentative generalization on the metabolism of other steroid conjugates in man. Recent Prog Horm Res 21:411-500
2. Orentreich N, Matias JR, Malloy V 1984 The local antiandrogenic effect of the intracutaneous injection of progesterone in the flank organ of sexually mature male Syrian golden hamster. Arch Dermatol Res 276:401-405
3. Belanger A, Candas B, Dupont A, Cusan L, Diamond P, Gomez JL, Labrie F 1994 Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. J Clin Endocrinol Metab 79:1086-1090
4. Lasley BL, Santoro N, Randolf JF, Gold EB, Crawford S, Weiss G, McConnell DS, Sowers MF 2002 The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab 87:3760-3767
5. i protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression. Endocrinology 148:3068-3076
6. Barrett-Connor E, Khaw KT, Yen SS 1986 A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med 315:1519-1524
7. Slowinska-Srzednicka J, Zgliczynski S, Soszynski P, Makowska A, Zgliczynski W, Srzednicki M, Bednarska M, Chotkowska E, Woroszylska M, Ruzyllo W 1991 Decreased plasma levels of dehydroepiandrosterone sulphate (DHEA-S) in normolipidemic and hyperlipoproteinemic young men with coronary artery disease. J Intern Med 230:551-553
8. Slowinska-Srzednicka J, Malczewska B, Srzednicki M, Chotkowska E, Brzezinska A, Zgliczynski W, Ossowski M, Jeske W, Zgliczynski S, Sadowski Z 1995 Hyperinsulinemia and decreased plasma levels of dehydroepiandrosterone sulfate in premenopausal women with coronary heart disease. J Intern Med 237:465-472
9. Johannes CB, Stellato RK, Feldman HA, Longcope C, McKinlay JB 1999 Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardiovascular disease risk factors in women: longitudinal results from the Massachusetts Women's Health Study. J Clin Epidemiol 52:95-103
10. Mitchell LE, Sprecher DL, Borecki IB, Rice T, Laskarzewski PM, Rao DC 1994 Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males. Circulation 89:89-93
11. Herrington DM, Gordon GB, Achuff SC, Trejo JF, Weisman HF, Kwiterovich Jr PO, Pearson TA 1990 Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. J Am Coll Cardiol 16:862-870
12. Herrington DM, Nanjee N, Achuff SC, Cameron DE, Dobbs B, Baughman KL 1996 Dehydroepiandrosterone and cardiac allograft vasculopathy. J Heart Lung Transplant 15:88-93
13. Barrett-Connor E, Goodman-Gruen D 1995 The epidemiology of DHEAS and cardiovascular disease. Ann NY Acad Sci 774:259-270
14. Berr C, Lafont S, Debuire B, Dartigues JF, Baulieu EE 1996 Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study. Proc Natl Acad Sci USA 93:13410-13415
15. Mazat L, Lafont S, Berr C, Debuire B, Tessier JF, Dartigues JF, Baulieu EE 2001 Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci USA 98:8145-8150
16. Christopher-Hennings J, Kurzman ID, Haffa AL, Kemnitz JW, Macewen EG 1995 The effect of high fat diet and dehydroepiandrosterone (DHEA) administration in the rhesus monkey. In Vivo 9:415-420
17. Gordon GB, Bush DE, Weisman HF 1988 Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury. J Clin Invest 82:712-720
18. Eich DM, Nestler JE, Johnson DE, Dworkin GH, Ko D, Wechsler AS, Hess ML 1993 Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. Circulation 87:261-269
19. Stomati M, Monteleone P, Casarosa E, Quirici B, Puccetti S, Bernardi F, Genazzani AD, Rovati L, Luisi M, Genazzani AR 2000 Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol 14:342-363
20. Labrie F, Luu-The V, Labrie C, Simard J 2001 DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol 22:185-212
21. Hayashi T, Esaki T, Muto E, Kano H, Asai Y, Thakur NK, Sumi D, Jayachandran M, Iguchi A 2000 Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. Arterioscler Thromb Vasc Biol 20:782-792
22. Liu D, Dillon JS 2002 Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Gαi2,3. J Biol Chem 277:21379-21388
23. Simoncini T, Mannella P, Fornari L, Varone G, Caruso A, Genazzani AR 2003 Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 144:3449-3455
24. Simoncini T, Genazzani AR 2003 Non-genomic actions of sex steroid hormones. Eur J Endocrinol 148:281-292
25. Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, Liao JK 2000 Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407:538-541
26. Simoncini T, Rabkin E, Liao JK 2003 Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells. Arterioscler Thromb Vasc Biol 23:198-203
27. Simoncini T, Mannella P, Fornari L, Caruso A, Willis MY, Garibaldi S, Baldacci C, Genazzani AR 2004 Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology 145:5745-5756
28. Hafezi-Moghadam A, Simoncini T, Yang E, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK 2002 Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 8:473-479