Administration of recombinant activated factor VII (NovoSeven) in three cases of uncontrolled bleeding caused by disseminated intravascular coagulopathy

Clinical and Applied Thrombosis/Hemostasis

Volumn 13, Issue 3, 2007, Pages 313-317

  Schmid, Stefan ^a   Friesenecker, Barbara ^a   Lorenz, Ingo ^a   Innerhofer, Petra ^a   Koscielny, Jürgen ^b   Velik Salchner, Corinna ^a   Mutz, Norbert ^a   Fries, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Bleeding; Disseminated intravascular coagulation; Disseminated intravascular coagulopathy; rFVIIa

Indexed keywords

ANTITHROMBIN; APROTININ; CARBAPENEM; CATECHOLAMINE; CIPROFLOXACIN; D DIMER; DESMOPRESSIN; FIBRINOGEN; FRESH FROZEN PLASMA; NONSTEROID ANTIINFLAMMATORY AGENT; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ABDOMINAL BLEEDING; ADULT; AGED; ARTICLE; ARTIFICIAL EMBOLISM; BLEEDING; BLOOD TRANSFUSION; CASE REPORT; DEATH; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; HOSPITAL DISCHARGE; HUMAN; LOW BACK PAIN; MULTIPLE ORGAN FAILURE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROGNOSIS; PROTHROMBIN TIME; SEPSIS; SINGLE DRUG DOSE; SURVIVAL; THROMBOCYTE COUNT; THROMBOEMBOLISM;

ADULT; AGED; DISSEMINATED INTRAVASCULAR COAGULATION; FACTOR VII; FATAL OUTCOME; FEMALE; HUMANS; MALE; MULTIPLE ORGAN FAILURE; RECOMBINANT PROTEINS;

EID: 34347216700     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029607302567     Document Type: Article

References (19)

1. Hambleton J., Leung LL, Levi M. Coagulation: consultive hemostasis. Hematology Am Soc Hematol Educ Program. 2002: 335-352.
2. Taylor FB Jr, Toh CH, Hoots WK, et al. Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 ; 86: 1327-1330.
3. DeSancho MT, Rand JH Bleeding and thrombotic complications in critically ill patients with cancer. Crit Care Clin. 2001 ; 17: 599-622.
4. Alving BM, Spivak JL, DeLoughery TG Consultative hematology: hemostasis and transfusion issues in surgery and critical care medicine. In: McArthur JR, Schechter GP, Schrier SL, eds. Hematology 1998: The American Society of Hematology Education Program Book. Washington, DC: American Society of Hematology ; 1998: 320-341.
5. Lynn M., Jeroukhimov I., Klein Y., Martinowitz U. Updates in management of severe coagulopathy in trauma patients. Intensive Care Med. 2002 ; 28 (suppl 2). 241-247.
6. Silva MA, Muralidharan V., Mirza DF The management of coagulopathy and blood loss in liver sugery. Semin Hematol. 2004 ;(suppl 1). 132-139.
7. Haas T., Innerhofer P., Kühbacher G., Fries D. Successful reversal of deleterious coagulopathy by recombinant factor VIIa. Anesth Analg. 2005 ; 100: 54-58.
8. Gerotziafas GT, Zervas K., Arzoglou P., et al. On the mechanism of action of recombinant activated factor VII administered to patients with severe thrombocytopenia and life-threatening haemorrhage: focus on prothrombin activation. Br J Haematol. 2002 ; 117: 705-708.
9. Roberts HR, Monroe DM, Hoffmman M. Safety profile of recombinant factor VIIa. Semin Hematol. 2004 ; 41 (suppl 1). 101-108.
10. Negrier C., Lienhart A. Overall experience with NovoSeven. Blood Coagul Fibrinolysis. 2000 ; 11: 19-24.
11. Gando S. Disseminated intravascular coagulation in trauma patients. Semin Thromb Hemost. 2001 ; 27: 585-592.
12. Dempfle CE Coagulopathy of sepsis. Thromb Hemost. 2004 ; 91: 213-224.
13. Levi M., de Jonge E., van der Poll T., ten Cate H. Advances in the understanding of the pathogenic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies. Semin Thromb Hemost. 2001 ; 27: 569-575.
14. Mammen EF Disseminated intravascular coagulation (DIC). Clin Lab Sci. 2000 ; 13: 239-245.
15. Stanworth S., Brunskill S., Hyde CJ, McClelland D., Murphy M. Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials. Br J Haematol. 2004 ; 126: 139-152.
16. Chowdhury P., Saayman A., Paulus U., Findlay G., Collins P. Efficacy of standard dose and 30 mL/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol. 2004 ; 125: 69-73.
17. Sallah S., Husain A., Nguyen NP Recombinant activated factor VII in patients with cancer and hemorrhagic disseminated intravascular coagulation. Blood Coagul Fibrinolysis. 2004 ; 15: 577-582.
18. Moscardo F., Perez F., De La Rubia J., et al. Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII. Br J Haematol. 2001 ; 113: 174-176.
19. Cid AR, Martinez J., Aznart JA, et al. Treatment with recombinant activated factor VIIa of intraabdominal bleeding associated with disseminated intravascular coagulation caused by septic shock. Presented at: the XIX Congress of the International Society of Thrombosis and Haemostasis 2003, Birmingham, UK.