Role of p53 and CDKN2A inactivation in human squamous cell carcinomas

Journal of Biomedicine and Biotechnology

Volumn 2007, Issue , 2007, Pages

  Pacifico, Alessia ^a   Leone, Giovanni ^a  

^a SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2A; PROTEIN P53; UNCLASSIFIED DRUG;

DEREGULATION; DISEASE COURSE; ENZYME INACTIVATION; GENE; GENE MUTATION; GENE SILENCING; GENETIC DISORDER; HUMAN; MELANOMA; NONHUMAN; REVIEW; SKIN CANCER; SQUAMOUS CELL CARCINOMA; ULTRAVIOLET RADIATION;

EID: 34250899173     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2007/43418     Document Type: Review

References (32)

1. T. L. Diepgen V. Mahler The epidemiology of skin cancer. British Journal of Dermatology 146 61 supplement 2002 1 6
2. M. Alam D. Ratner Cutaneous squamous-cell carcinoma. New England Journal of Medicine 344 13 2001 975 983
3. N. Soufir J. P. Molès C. Vilmer p16 UV mutations in human skin epithelial tumors. Oncogene 18 39 1999 5477 5481
4. N. Soufir L. Daya-Grosjean P. de La Salmonière Association between INK4a-ARF and p53 mutations in skin carcinomas of xeroderma pigmentosum patients. Journal of the National Cancer Institute 92 22 2000 1841 1847
5. D. J. Leffell The scientific basis of skin cancer. Journal of the American Academy of Dermatology 42 1, supplement 1 2000 S18 S22
6. M. L. Kripke Immunological effects of ultraviolet radiation. Journal of Dermatology 18 8 1991 429 433
7. F. R. de Gruijl f.r.de_gruijl@lumc.nl H. J. van Kranen L. H. F. Mullenders UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. Journal of Photochemistry and Photobiology B: Biology 63 1-3 2001 19 27
8. K. Y. Tsai H. Tsao htsao@partners.org The genetics of skin cancer. American Journal of Medical Genetics 131C 1 2004 82 92
9. A. J. Nataraj J. C. Trent H. N. Ananthaswamy p53 gene mutations and photocarcinogenesis. Photochemistry and Photobiology 62 2 1995 218 230
10. A. S. Jonason S. Kunala G. J. Price Frequent clones of p53-mutated keratinocytes in normal human skin. Proceedings of the National Academy of Sciences of the United States of America 93 24 1996 14025 14029
11. R. J. W. Berg H. J. van Kranen H. G. Rebel Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Proceedings of the National Academy of Sciences of the United States of America 93 1 1996 274 278
12. H. N. Ananthaswamy S. M. Loughlin P. Cox R. L. Evans S. E. Ullrich M. L. Kripke Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens. Nature Medicine 3 5 1997 510 514
13. R. A. Weinberg The retinoblastoma protein and cell cycle control. Cell 81 3 1995 323 330
14. L. Chin J. Pomerantz R. A. Depinho ronald_depinho@dfci.harvard.edu The INK4a/ARF tumor suppressor: one gene - two products - two pathways. Trends in Biochemical Sciences 23 8 1998 291 296
15. V. O. Melnikova H. N. Ananthaswamy hanantha@mdanderson.org Cellular and molecular events leading to the development of skin cancer. Mutation Research 571 1-2 2005 91 106
16. N. Soufir M. Ribojad T. Magnaldo Germline and somatic mutations of the INK4a-ARF gene in a xeroderma pigmentosum group C patient. Journal of Investigative Dermatology 119 6 2002 1355 1360
17. V. L. Brown C. A. Harwood T. Crook J. G. Cronin D. R. Kelsell C. M. Proby c.proby@cancer.org.uk p 16 INK 4 a and p 14 ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma. Journal of Investigative Dermatology 122 5 2004 1284 1292
18. V. Dulic W. K. Kaufmann S. J. Wilson p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76 6 1994 1013 1023
19. M. S. Sheikh Y. Q. Chen M. L. Smith A. J. Fornace Jr. Role of p2 1 Waf 1 /Cip 1 /Sdi 1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 14 15 1997 1875 1882
20. A. J. Levine p53, the cellular gatekeeper for growth and division. Cell 88 3 1997 323 331
21. D. P. Lane p53, guardian of the genome. Nature 358 6381 1992 15 16
22. M. Hollstein D. Sidransky B. Vogelstein C. C. Harris p53 mutations in human cancers. Science 253 5015 1991 49 53
23. H. N. Ananthaswamy S. M. Loughlin S. E. Ullrich M. L. Kripke Inhibition of UV-induced p53 mutations by sunscreens: implications for skin cancer prevention. Journal of Investigative Dermatology Symposium Proceedings 3 1 1998 52 56
24. D. E. Brash J. A. Rudolph J. A. Simon A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America 88 22 1991 10124 10128
25. S. Bolshakov C. M. Walker S. S. Strom p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. Clinical Cancer Research 9 1 2003 228 234
26. A. Ouhtit A. Gorny H. K. Muller L. L. Hill L. Owen-Schaub H. N. Ananthaswamy Loss of fas-ligand expression in mouse keratinocytes during UV carcinogenesis. American Journal of Pathology 157 6 2000 1975 1981
27. V. O. Melnikova A. Pacifico S. Chimenti K. Peris H. N. Ananthaswamy hanantha@mdanderson.org Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development. Oncogene 24 47 2005 7055 7063
28. F. J. Stott S. Bates M. C. James The alternative product from the human CDKN2A locus, p 14 ARF, participates in a regulatory feedback loop with p53 and MDM2. EMBO Journal 17 17 1998 5001 5014
29. M. Serrano H.-W. Lee L. Chin C. Cordon-Cardo D. Beach R. A. DePinho Role of the INK4a locus in tumor suppression and cell mortality. Cell 85 1 1996 27 37
30. J. G. Herman C. I. Civin J.-P. J. Issa M. I. Collector S. J. Sharkis S. B. Baylin Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Research 57 5 1997 837 841
31. Z. Saridaki T. Liloglou A. Zafiropoulos E. Koumantaki O. Zoras D. A. Spandidos spandidos@spandidos.gr Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin. British Journal of Dermatology 148 4 2003 638 648
32. K. Murao Y. Kubo ykubo@clin.med.tokushima-u.ac.jp N. Ohtani E. Hara S. Arase Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways. British Journal of Dermatology 155 5 2006 999 1005