Alginate-based pellets prepared by extrusion/spheronization: A preliminary study on the effect of additive in granulating liquid

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 67, Issue 1, 2007, Pages 227-235

  Sriamornsak, Pornsak ^a   Nunthanid, Jurairat ^a   Luangtana anan, Manee ^a   Puttipipatkhachorn, Satit ^b  

^a SILPAKORN UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Alginate; Basket extruder; Extrusion; Granulating liquid; Pellets; Spheronization

Indexed keywords

ALGINIC ACID; CALCIUM ION; MICROCRYSTALLINE CELLULOSE; THEOPHYLLINE;

ARTICLE; CROSS LINKING; DISSOLUTION; DRUG RELEASE; PELLET EXTRUSION; SPHERONIZATION;

ALGINATES; ALGORITHMS; CALCIUM CHLORIDE; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; GELS; MODELS, STATISTICAL; PARTICLE SIZE; SOLUBILITY;

EID: 34250873379     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.11.007     Document Type: Article

References (20)

1. Bechgaard H., and Nielsen H. Controlled Release multiple units and single unit doses. Drug Dev. Ind. Pharm. 4 (1978) 53-67
2. Law M.F.L., and Deasy P.B. Use of hydrophilic polymers with microcrystalline cellulose to improve extrusion/spheronization. Eur. J. Pharm. Biopharm. 48 (1998) 57-65
3. Tho I., Kleinebudde P., and Sande S.A. Extrusion/spheronization of pectin-based formulations. I. Screening of important factors. AAPS Pharm. Sci. Tech. 2 (2001). http://www.aapspharmscitech.org article 26. (http://www.aapspharmscitech.org)
4. Tho I., Kleinebudde P., and Sande S.A. Extrusion/spheronization of pectin-based formulations. II. Effect of additive concentration in the granulating liquid. AAPS Pharm. Sci. Tech. 2 (2001). http://www.aapspharmscitech.org article 27. (http://www.aapspharmscitech.org)
5. Steckel H., and Mindermann-Nogly F. Production of chitosan pellets by extrusion/spheronization. Eur. J. Pharm. Biopharm. 57 (2004) 107-114
6. Haug A., and Larsen B. Quantitative determination of the uronic acid composition of alginates. Acta Chem. Scand. 16 (1962) 1908-1918
7. Haug A., Larsen B., and Smidsrod O. Studies on the sequence of uronic acid residues in alginic acid. Acta Chem. Scand. 21 (1967) 691-704
8. Hodsdon A.C., Mitchell J.R., Davies M.C., and Melia C.D. Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3.The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices. J. Control. Rel. 33 (1995) 143-152
9. Bhagat H.R., Mendes R.W., Mathiowitz E., and Bhargava H.N. Novel, self-correcting membrane coating technique. Pharm. Res. 8 (1990) 576-583
10. Sriamornsak P., Burton M.A., and Kennedy R.A. Development of polysaccharide gel coated pellets for oral administration. 1. Physico-mechanical properties. Int. J. Pharm. 326 (2006) 80-88
11. Sriamornsak P., and Kennedy R.A. Development of polysaccharide gel coated pellets for oral administration. 2. Calcium alginate. Eur. J. Pharm. Sci. 29 (2006) 139-147
12. Aynie I., Vauthier C., Chacun H., Fattal E., and Couvreur P. Spongelike alginate nanoparticles as a new potential system for the delivery of antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 9 (1999) 301-312
13. Whitehead L., Collett J.H., and Fell J.T. Amoxycillin release from a floating dosage form based on alginates. Int. J. Pharm. 210 (2000) 45-49
14. Chatchawalsaisin J., Podczeck F., and Newton J.M. The influence of chitosan and sodium alginate and formulation variables on the formulation and drug release from pellets prepared by extrusion/spheronization. Int. J. Pharm. 275 (2004) 41-60
15. Baert L., and Remon J.P. Influence of amount of granulating liquid on the drug release rate from pellets made of extrusion/spheronization. Int. J. Pharm. 95 (1993) 135-141
16. Chatlapalli R., and Rohera B.D. Physical characterization of HPMC and HEC and investigation of their use as pelletization aids. Int. J. Pharm. 161 (1998) 179-193
17. Schroder M., and Kleinebudde P. Structure of disintegrating pellets with regard to fractal geometry. Pharm. Res. 12 (1995) 1694-1700
18. 2+-induced gelation in alginates and pectins: The egg-box model revisited. Biomacromolecules 2 (2001) 1089-1096
19. Higuchi T. Mechanism of sustained-action medication: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52 (1963) 1145-1149
20. Korsmeyer R.W., Gurny R., Docler E., Buri P., and Peppas N.A. Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm. 15 (1983) 25-35