The influence of chitosan and sodium alginate and formulation variables on the formation and drug release from pellets prepared by extrusion/spheronisation

International Journal of Pharmaceutics

Volumn 275, Issue 1-2, 2004, Pages 41-60

  Chatchawalsaisin, Jittima ^a   Podczeck, Fridrun ^b   Newton, J Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Drug release; Extrusion spheronisation; Hydrophilic polymers (chitosan, sodium alginate); Pellet properties

Indexed keywords

ALGINIC ACID; CHITOSAN; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; POLYMER;

ARTICLE; COMPLEX FORMATION; DENSITY; DISSOLUTION; DRUG DESIGN; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG RELEASE; DRUG SYNTHESIS; EXPERIMENTAL MODEL; HYDROPHILICITY; LIQUID; PARTICLE SIZE; PELLET EXTRUSION; PRIORITY JOURNAL; SPHERONIZATION; STANDARDIZATION; STATISTICAL ANALYSIS; STEADY STATE; TECHNIQUE;

ACETAMINOPHEN; ADJUVANTS, PHARMACEUTIC; ALGINATES; CHEMISTRY, PHARMACEUTICAL; CHITIN; CHITOSAN; DOSAGE FORMS; DRUG CARRIERS; DRUG COMPOUNDING; GLUCURONIC ACID; HEXURONIC ACIDS; POROSITY; SOLUBILITY; TIME FACTORS;

EID: 1842638448     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.01.025     Document Type: Article

References (21)

1. Blanque D., Sternagel H., Podczeck F., Newton J.M. Some factors influencing the formation and in vitro drug releaser from matrix pellets prepared by extrusion/spheronisation. Int. J. Pharm. 119:1995;203-211.
2. Boutell S.L., Newton J.M., Bloor J.R., Hayes G. The influence of liquid binder on the liquid mobility and preparation of spherical granules by the process of extrusion/spheronisation. Int. J. Pharm. 238:2002;61-76.
3. Chopra R., Newton J.M., Alderborn G., Podczeck F. Preparation of pellets of different shape and their characterization. Pharm. Dev. Tech. 6:2001;495-503.
4. Fielden K.E., Newton J.M., O'Brien P., Rowe R.C. Thermal studies on the interaction of water and microcrystalline cellulose. J. Pharm. Pharmacol. 40:1988;647-678.
5. Funck J.A.B., Schwartz J.B., Reilly W.J., Ghali E.S. Binder effectiveness for beads with high drug levels. Drug Dev. Ind. Pharm. 17:1991;1143-1156.
6. Ghali E.S., Klinger G.H., Schwartz J.B. Modified drug release from beads prepared with combinations of two grades of microcrystalline cellulose. Drug Dev. Ind. Pharm. 15:1989;1455-1473.
7. Goskonda S.R., Upadrashta S.M. Avicel RC-591/chitosan beads by extrusion/spheronization. Drug Dev. Ind. Pharm. 19:1993;915-927.
8. Harrison P.J., Newton J.M., Rowe R.C. The characterization of wet powder masses suitable for extrusion/spheronization. J. Pharm. Pharmacol. 37:1985;685-691.
9. Heng P.W.S., Koo O.M.Y. A study of the effects of the physical characteristics of microcrystalline cellulose on the performance in extrusion spheronization. Pharm. Res. 18:2001;480-487.
10. Law M.F.L., Deasy P.B. Use of canonical analysis and other analysis for the optimisation of an extrusion-spheronization process for indomethacin. Int. J. Pharm. 146:1997;1-9.
11. Neau S.H., Chow M.Y., Durrani M.J. Fabrication and characterization of extruded and spheronised beads containing Carbopol 974P, NF resin. Int. J. Pharm. 131:1996;47-55.
12. Newton J.M., Chow A.K., Jeewa K.B. The effect of excipient source on spherical granules made by extrusion/spheronisation. Pharm. Tech. Int. 4:1992;52-58.
13. Newton, J.M., 2002. Extrusion and extruders. In: Swarbrick, J., Boylan, J.C. (Eds.), Encyclopaedia of Pharmaceutical Technology, second ed., vol. 2, Marcel Dekker, New York, pp. 1220-1236.
14. O'Connor R.E., Schwartz J.B. Spheronization II: drug release from drug-diluent mixtures. Drug Dev. Ind. Pharm. 11:1985;1837-1857.
15. Podczeck, F., 1995. The development and optimisation of tablet formulations using mathematical methods. In: Alderborn, G., Nystrom, C. (Eds.), Pharmaceutical Powder Compaction Technology. Marcel Dekker, New York, pp. 561-593.
16. Podczeck F., Merkel G., Revesz P. The application of canonical analysis to the evaluation of the influence of changes in the components of standard direct compression tablet formulations. Int. J. Pharm. 97:1993;15-28.
17. Podczeck F., Newton J.M. A shape factor to characterize the quality of spheroids. J. Pharm. Pharmacol. 46:1994;82-85.
18. Raines, C.L., Newton, J.M., Rowe, R.C., 1990. Extrusion of microcrystalline cellulose formulations. In: Carter, R.F. (Ed.), Rheology of Food, Pharmaceutical and Biological Materials with General Rheology. Elsevier Applied Science, London, pp. 248-257.
19. Sawayanagi Y., Nambu N., Nagai T. Directly compressed tablets containing chitin in addition to mannitol. Chem. Pharm. Bull. 30:1982;4216-4218.
20. Tapia C., Buckton G., Newton J.M. Factors influencing the mechanism of release from sustained release matrix pellets, produced by extrusion/ spheronization. Int. J. Pharm. 92:1993;211-218.
21. Voegele, D., Brockmeier, D., von Hattingberg, H.M., 1988. Modelling of input functions to drug absorption moments. In: Proceedings of the Symposium on Compartmental and Non-Compartmental Modelling in Pharmacokinetics, Smolenice, Czechoslovakia, 12-16 September, p. 1-14.