Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang

Chinese Journal of Medical Genetics

Volumn 24, Issue 3, 2007, Pages 341-344

  Fu, Xin Ge ^a   Li, Feng ^a   Wang, Zhen Hua ^b   Hu, Wen Hao ^a   Mikai, Re Mu ^c   Jiang, Jin Fang ^a   Li, Hong An ^a   Li, Li ^a   Zheng, Yu Qin ^a   Shen, Xi Hua ^a   Pang, Li Juan ^a  

^a SHIHEZI UNIVERSITY   (China)

^b XINJIANG MEDICAL UNIVERSITY   (China)

^c Tuberculosis hospital of Kashi Prefecture   (China)

Author keywords

BRCA1 gene; Breast cancer; DNA sequencing; Mutation; Single strand conformation polymorphism

Indexed keywords

BRCA1 PROTEIN;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BREAST NEOPLASMS; CHINA; ETHNIC GROUPS; FEMALE; GENES, BRCA1; HUMANS; INTRONS; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 34250862033     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Iiminger FI, Siegel BD, Leung WC. The functions of breast cancer susceptibility gene1 (BRCA1) product and its associated proteins. Biol Chem, 1999,380:117:128.
2. Sakorafas GH, Tsiotou AG. Genetic predisposition to breast cancer: a surgical perspective. Br J Surg, 2000, 87:149-162.
3. Bergman A, Flodin A, Engwall Y, et al. A high frequency of germline BRCA1/2 mutations in western Sweden detected with complementary screening techniques. Familial Cancer, 2005, 4:89-96.
4. Gorski B, Byrski T, Huzarski T, et al. Founder mutations in the BRCA1 gene in polish families with breast-ovarian cancer. Am J Hum Genet, 2000, 66:963-1968.
5. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science, 1994, 266:66-71.
6. Friedman LS, Ostermeyer EA, Szabo CI, et al. Confirmation of BRCA1 by analysis of gremlin mutations linked to breast and ovarian cancer in ten families. Nat Genet, 1994, 8:399-404.
7. Pohlreich P, Zikan M, Stribma J, et al. High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area. Breast Cancer Res, 2005, 7:728-736.
8. Lai CN, Jiang ZF, Song ST, et al. Mutation BRCA1 gene in 186 breast cancer patients. Chin J Oncol, 2001,23:483-485.
9. Song CG, Hu Z, Yuan WT, et al. Mutation analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai. National Medical J China, 2005,85:3030-3034.
10. Maillet P, Chappuis PO, Khoshbeen-Boudal M, et al. Twenty-three novel BRCA1 and BRCA2 sequence variations identified in a cohort of Swiss breast and ovarian cancer families. Cancer Genetics and Cytogenetics, 2006, 169:62-68.
11. Gallaido M, Silva A, Rubio L, et al. Incidence of BRCA1 and BRCA2 mutations in 54 Chilean families with breast/ovarian cancer, genotype phenotype correlations. Breast Cancer Res Treatment, 2006,95: 81-87.