Mutability of an HNH nuclease imidazole general base and exchange of a deprotonation mechanism

Biochemistry

Volumn 46, Issue 24, 2007, Pages 7215-7225

  Eastberg, Jennifer H ^a   Eklund, Jennifer ^a,b   Monnat Jr , Raymond ^a   Stoddard, Barry L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BINDING SITES; DNA; MUTAGENESIS; NITROGEN COMPOUNDS;

COLICINS; ENDONUCLEASES; GLUTAMINE; HISTIDINE; LYSINE; PHOSPHODIESTER BONDS;

ENZYME KINETICS;

COLICIN; ENDONUCLEASE; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; IMIDAZOLE DERIVATIVE; LYSINE; MUTANT PROTEIN; NUCLEASE; RESTRICTION ENDONUCLEASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; HYDROLYSIS; MUTATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN MOTIF; PROTON TRANSPORT; STEREOCHEMISTRY;

BASE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEASES; DNA; ELECTROSTATICS; ENDODEOXYRIBONUCLEASES; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; PROTONS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 34250858251     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700418d     Document Type: Article

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