Predictable αβ T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope

Journal of Virology

Volumn 81, Issue 13, 2007, Pages 7269-7273

  Brennan, Rebekah M ^a   Miles, John J ^a,b   Silins, Sharon L ^a   Bell, Melissa J ^a   Burrows, Jacqueline M ^a   Burrows, Scott R ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; EPITOPE; HLA B ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; VIRUS ANTIGEN; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; HLA B*3501 ANTIGEN; HLA-B*3501 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MATRIX PROTEIN; PHOSPHOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; BLOOD; CYTOMEGALIC INCLUSION BODY DISEASE; CYTOMEGALOVIRUS; IMMUNOLOGY;

HUMAN HERPESVIRUS 5;

ANTIGENS, VIRAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; EPITOPES, T-LYMPHOCYTE; HLA-B ANTIGENS; HUMANS; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; VIRAL MATRIX PROTEINS;

EID: 34250844278     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00356-07     Document Type: Article

References (36)

1. Arstila, T. P., A. Casrouge, V. Baron, J. Even, J. Kanellopoulos, and P. Kourilsky. 1999. A direct estimate of the human αβ T cell receptor diversity. Science 286:958-961.
2. Burrows, J. M., K. K. Wynn, F. E. Tynan, J. Archbold, J. J. Miles, M. J. Bell, R. M. Brennan, S. Walker, J. McCluskey, J. Rossjohn, R. Khanna, and S. R. Burrows. 2007. The impact of HLA micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. Eur. J. Immunol. 37:946-953.
3. Buslepp, J., H. Wang, W. E. Biddison, E. Appella, and E. J. Collins. 2003. A correlation between TCR Vα docking on MHC and CD8 dependence: implications for T cell selection. Immunity 19:595-606.
4. Gandhi, M. K., and R. Khanna. 2004. Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect. Dis. 4:725-738.
5. Gavin, M. A., M. J. Gilbert, S. R. Riddell, P. D. Greenberg, and M. J. Bevan. 1993. Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes. J. Immunol. 151:3971-3980.
6. + T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype. J. Infect. Dis. 185:1025-1034.
7. Khan, N., A. Hislop, N. Gudgeon, M. Cobbold, R. Khanna, L. Nayak, A. B. Rickinson, and P. A. Moss. 2004. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J. Immunol. 173:7481-7489.
8. Khan, N., N. Shariff, M. Cobbold, R. Bruton, J. A. Ainsworth, A. J. Sinclair, L. Nayak, and P. A. Moss. 2002. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169:1984-1992.
9. Kjer-Nielsen, L., C. S. Clements, A. W. Purcell, A. G. Brooks, J. C. Whisstock, S. R. Burrows, J. McCluskey, and J. Rossjohn. 2003. A structural basis for the selection of dominant αβ T cell receptors in antiviral immunity. Immunity 18:53-64.
10. Leen, A. M., G. D. Myers, U. Sili, M. H. Huls, H. Weiss, K. S. Leung, G. Carrum, R. A. Krance, C. C. Chang, J. J. Molldrem, A. P. Gee, M. K. Brenner, H. E. Heslop, C. M. Rooney, and C. M. Bollard. 2006. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat. Med. 12:1160-1166.
11. Lidehall, A. K., F. Sund, T. Lundberg, B. M. Eriksson, T. H. Totterman, and O. Korsgren. 2005. T cell control of primary and latent cytomegalovirus infections in healthy subjects. J. Clin. Immunol. 25:473-481.
12. Meyer-Olson, D., N. H. Shoukry, K. W. Brady, H. Kim, D. P. Olson, K. Hartman, A. K. Shintani, C. M. Walker, and S. A. Kalams. 2004. Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J. Exp. Med. 200:307-319.
13. Miles, J. J., N. A. Borg, R. M. Brennan, F. E. Tynan, L. Kjer-Nielsen, S. L. Silins, M. J. Bell, J. M. Burrows, J. McCluskey, J. Rossjohn, and S. R. Burrows. 2006. TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope. J. Immunol. 177: 6804-6814.
14. Miles, J. J., S. L. Silins, and S. R. Burrows. 2006. Engineered T cell receptors and their potential in molecular medicine. Curr. Med. Chem. 13:2725-2736.
15. Olsson, J., A. Wikby, B. Johansson, S. Lofgren, B. O. Nilsson, and F. G. Ferguson. 2000. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 121:187-201.
16. + T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp. Gerontol. 38:911-920.
17. + T cells accumulate in the elderly. Exp. Gerontol. 39:607-613.
18. Pass, R. F. 1985. Epidemiology and transmission of cytomegalovirus. J. Infect. Dis. 152:243-248.
19. Peggs, K. S., S. Verfuerth, A. Pizzey, N. Khan, M. Guiver, P. A. Moss, and S. Mackinnon. 2003. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet 362:1375-1377.
20. + T cell populations specific for persistent DNA viruses. J. Exp. Med. 202:1349-1361.
21. Price, D. A., S. M. West, M. R. Betts, L. E. Ruff, J. M. Brenchley, D. R. Ambrozak, Y. Edghill-Smith, M. J. Kuroda, D. Bogdan, K. Kunstman, N. L. Letvin, G. Franchini, S. M. Wolinsky, R. A. Koup, and D. C. Douek. 2004. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity 21:793-803.
22. Riddell, S. R., K. S. Watanabe, J. M. Goodrich, C. R. Li, M. E. Agha, and P. D. Greenberg. 1992. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257:238-241.
23. Rudolph, M. G., R. L. Stanfield, and I. A. Wilson. 2006. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24:419-466.
24. Soderberg-Naucler, C. 2006. Human cytomegalovirus persists in its host and attacks and avoids elimination by the immune system. Crit. Rev. Immunol. 26:231-264.
25. Sohn, Y. M., M. K. Oh, K. B. Balcarek, G. A. Cloud, and R. F. Pass. 1991. Cytomegalovirus infection in sexually active adolescents. J. Infect. Dis. 163: 460-463.
26. Stewart-Jones, G. B., A. J. McMichael, J. I. Bell, D. I. Stuart, and E. Y. Jones. 2003. A structural basis for immunodominant human T cell receptor recognition. Nat. Immunol. 4:657-663.
27. + T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 202:673-685.
28. Trautmann, L., M. Rjmbert, K. Echasserieau, X. Saulquin, B. Neveu, J. Dechanet, V. Cerundolo, and M. Bonneville. 2005. Selection of T cell clones expressing high-affinity public TCRs within human cytomegalovirus-specific CD8 T cell responses. J. Immunol. 175:6123-6132.
29. Turner, S. J., P. C. Doherty, J. McCluskey, and J. Rossjohn. 2006. Structural determinants of T-cell receptor bias in immunity. Nat. Rev. Immunol. 6:883-894.
30. + T cell populations. Nat. Immunol. 6:382-389.
31. Tynan, F. E., S. R. Burrows, A. M. Buckle, C. S. Clements, N. A. Borg, J. J. Miles, T. Beddoe, J. C. Whisstock, M. C. Wilce, S. L. Silins, J. M. Burrows, L. Kjer-Nielsen, L. Kostenko, A. W. Purcell, J. McCluskey, and J. Rossjohn. 2005. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nat. Immunol. 6:1114-1122.
32. Tynan, F. E., H. H. Reid, L. Kjer-Nielsen, J. J. Miles, M. C. Wilce, L. Kostenko, N. A. Borg, N. A. Williamson, T. Beddoe, A. W. Purcell, S. R. Burrows, J. McCluskey, and J. Rossjohn. 2007. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat. Immunol. 8:268-276.
33. Wallace, M. E., M. Bryden, S. C. Cose, R. M. Coles, T. N. Schumacher, A. Brooks, and F. R. Carbone. 2000. Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1. Immunity 12:547-556.
34. Walter, E. A., P. D. Greenberg, M. J. Gilbert, R. J. Finch, K. S. Watanabe, E. D. Thomas, and S. R. Riddell. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333:1038-1044.
35. Weekes, M. P., M. R. Wills, K. Mynard, A. J. Carmichael, and J. G. Sissons. 1999. The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J. Virol. 73:2099-2108.
36. Wikby, A., B. Johansson, J. Olsson, S. Lofgren, B. O. Nilsson, and F. Ferguson. 2002. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37:445-453.