Quantitative determination of BMS-378806 in human plasma and urine by high-performance liquid chromatography/tandem mass spectrometry

Journal of Separation Science

Volumn 30, Issue 9, 2007, Pages 1267-1275

  Xue, Yong Jun ^a   Yan, Jing He ^b   Arnold, Mark ^a   Grasela, Dennis ^a   Unger, Steve ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

BMS 378806; Dilute and shoot; Human plasma and urine; LC MS MS; Liquid liquid extraction; Pharmacokinetics

Indexed keywords

DILUTION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLASMA (HUMAN); REGRESSION ANALYSIS; VIRUSES;

DILUTE-AND-SHOOT APPROACH; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN URINE METHOD; LIQUID-LIQUID EXTRACTION;

PHARMACOKINETICS;

4 BENZOYL 1 [(4 METHOXY 1H PYRROLO[2,3 B]PYRIDIN 3 YL)OXOACETYL] 2 METHYLPIPERAZINE; ACETONITRILE; FORMIC ACID; PLACEBO; WATER;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CALIBRATION; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISPOSITION; DRUG DOSE ESCALATION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG FATALITY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG SOLUTION; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; ERYTHEMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID DIET; NORMAL HUMAN; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; REGRESSION ANALYSIS; SIDE EFFECT; SINGLE DRUG DOSE; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; URINALYSIS; URINARY EXCRETION; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV FUSION INHIBITORS; HUMANS; PIPERAZINES; TANDEM MASS SPECTROMETRY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 34250837402     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200600499     Document Type: Article

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