Early maternal separation alters the response to traumatization: Resulting in increased levels of hippocampal neurotrophic factors

Metabolic Brain Disease

Volumn 22, Issue 2, 2007, Pages 183-195

  Faure, Jacqueline ^a   Uys, Joachim D K ^b   Marais, Lelanie ^a   Stein, Dan J ^c   Daniels, Willie M U ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Behaviour; Hippocampus; HPA axis; Maternal separation; Neurotrophic factor; Repeated stress; Time dependent sensitization

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CORTICOTROPIN; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN 3;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INJURY; LIFE STRESS; MALE; MATERNAL DEPRIVATION; MAZE TEST; NERVE FUNCTION; NONHUMAN; OPEN FIELD TEST; RAT; SENSITIZATION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; HIPPOCAMPUS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MATERNAL DEPRIVATION; MAZE LEARNING; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NEUROTROPHIN 3; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL;

ANIMALIA;

EID: 34250823518     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-007-9048-3     Document Type: Article

References (35)

1. Bannerman DM, Rawlins JNP, McHugh SB, Deacon RMJ, Yee BK, Bast T, Zhang W-N, Pothuizen HHJ, Feldon J (2004) Regional dissociations within the hippocampus-memory and anxiety. Neurosci Biobehav Rev 28:273-283
2. Barbany G, Persson H (1992) Regulation of neurotrophin mRNA expression in the rat brain by glucocorticoids. Eur J Neurosci 4:396-403
3. Brewin CR, Andrews B, Valentine JD (2000) Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol 68:748-766
4. Cirulli F, Micera A, Alleva E, Aloe L (1998) Early maternal separation increases NGF expression in the developing rat hippocampus. Pharmacol Biochem Behav 59:853-858
5. Cirulli F, Alleva E, Antonelli A, Aloe L (2000) NGF expression in the developing rat brain: effects of maternal separation. Dev Brain Res 123:129-134
6. Daniels WM, Pietersen CY, Carstens ME, Stein DJ (2004) Maternal separation in rats leads to anxiety-like behaviour and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metab Brain Dis 9:3-14
7. Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59:1116-1127
8. Duman RS, Heninger GR, Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606
9. Faure J, Uys JDK, Marais L, Stein DJ, Daniels WMU (2006) Early maternal separation followed by later stressors leads to dysregulation of the HPA-axis and increases in hippocampal NGF and NT-3 levels in a rat model. Metab Brain Dis 21:181-188
10. 1A/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in rats. Brain Res 983:97-107
11. Heim C, Owens MJ, Plotsky PM, Nemeroff CB (1997) Persistent changes in corticotrophin-releasing factor system due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder. Psychopharmacol Bull 33:185-192
12. Kanter ED, Wilkinson CW, Radant AD, Petrie EC, Dobie DJ, McFall ME, Peskind ER, Raskind MA (2001) Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder. Biol Psychiatry 50:238-245
13. Keane TM, Barlow DH (2001) Posttraumatic stress disorder. In: Anxiety and its disorders. Guilford Press, New York
14. Kessler RC, Magee WJ (1993) Childhood adversities and adult depression: basic patterns of association in a US national survey. Psychol Med 23:679-690
15. Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB, Meaney MJ, Plotsky PM (2000) Long-term behavioural and neuroendocrine adaptations to adverse early experience. In: Progress in brain research: the biological basis for mind body interactions. Elsevier, Amsterdam
16. Liberzon I, Krstov M, Young EA (1997) Stress-restress: effects on ACTH and fast feedback. Psychoneuroendocrinology 22:443-453
17. Lo DC (1996) Neurotrophic factors and synaptic plasticity. Neuron 15:979-981
18. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104-9110
19. Mullan E, Orrell M (1996) Early life experience in elderly women with a history of depression: a pilot study using the Brief Parenting Interview. Irish J Psychol Med 13:18-20
20. Nibuya M, Morinobu S, Duman RS (1995) Regulation of BDNF and trk B mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15:7539-7547
21. Raison CL, Miller AH (2003) When not enough is too much: the role of insufficient glucocorticoid signalling in the pathophysiology of stress-related disorders. Am J Psychiatry 160:1554-1565
22. Roceri M, Cirulli F, Pessina C, Peretto P, Racagni G, Riva MA (2004) Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions. Biol Psychiatry 55:708-714
23. Rodgers RJ, Dalvi A (1997) Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 21:801-810
24. Roesler TA, McKenzie N (1994) Effects of childhood trauma on psychological functioning in adults sexually abused as children. J Nerv Ment Dis 182:145-150
25. Roskoden T, Otten U, Schwegler H (2004) Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat. Exp Brain Res 154:183-191
26. Russo-Neustadt A, Ha T, Ramirez R, Kesslak JP (2001) Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behaviour in an animal model. Behav Brain Res 120:87-95
27. Schaaf MJ, de Jong J, de Kloet ER, Vreugdenhil E (1998) Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res 813:112-120
28. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM (1997) Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 56:131-137
29. Trivedi MA, Coover GD (2004) Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze. Neurobiol Learn Mem 81:172-184
30. Uys JD, Muller CJ, Marais L, Harvey BH, Stein DJ, Daniels WM (2006a) Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram. Neuroscience 137:619-625
31. Uys JDK, Marais L, Faure J, Prevoo D, Swart P, Stein DJ, Daniels WMU (2006b) Developmental trauma is associated with behavioural hyperarousal, altered HPA axis activity and decreased hippocampal neurotrophin expression in the adult rat. Ann N Y Acad Sci 1071:542-546
32. Wolfe DA, Sas L, Wekerle C (1994) Factors associated with the development of posttraumatic stress disorder among child victims of sexual abuse. Child Abuse Negl 18:37-50
33. Yehuda R, Antelman SM (1993) Criteria for evaluating animal models of posttraumatic stress disorder. Biol Psychiatry 33:479-486
34. Yehuda R, Kahana B, Schmeidler J, Southwick SM, Wilson S, Giller EL (1995) Impact of cumulative lifetime trauma and recent stress on current posttraumatic stress disorder symptoms in holocaust survivors. Am J Psychiatry 152:1815-1818
35. Yehuda R, Golier JA, Halligan SL, Meaney M, Bierer LM (2004) The ACTH response to dexamethasone in PTSD. Am J Psychiatry 161:1397-1403