메뉴 건너뛰기




Volumn 450, Issue 6, 2007, Pages 627-636

Grading invasive ductal carcinoma of the breast: Advantages of using automated proliferation index instead of mitotic count

Author keywords

Automation; Image analysis; Invasive breast carcinoma grading; MIB 1 (Ki 67) Immunohistochemistry; Survival

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN P53;

EID: 34250811439     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-007-0400-0     Document Type: Article
Times cited : (22)

References (58)
  • 2
    • 0016684166 scopus 로고
    • Prognosis in breast cancer utilizing histologic characteristics of the primary tumor
    • Black MM, Barclay THC, Hankey BF (1975) Prognosis in breast cancer utilizing histologic characteristics of the primary tumor. Cancer 36:2048-2055
    • (1975) Cancer , vol.36 , pp. 2048-2055
    • Black, M.M.1    Barclay, T.H.C.2    Hankey, B.F.3
  • 3
    • 70449185514 scopus 로고
    • Histologic grading in breast cancer: A study of 1,409 cases of which 359 have been followed for 15 years
    • Bloom HJG, Richardson WW (1957) Histologic grading in breast cancer: a study of 1,409 cases of which 359 have been followed for 15 years. Br J Cancer 11:359-377
    • (1957) Br J Cancer , vol.11 , pp. 359-377
    • Bloom, H.J.G.1    Richardson, W.W.2
  • 5
    • 0030010161 scopus 로고    scopus 로고
    • Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer
    • Brown RW, Allred CD, Clark GM, Osborne CK, Hilsenbeck SG (1996) Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer. Clin Cancer Res 2:585-592
    • (1996) Clin Cancer Res , vol.2 , pp. 585-592
    • Brown, R.W.1    Allred, C.D.2    Clark, G.M.3    Osborne, C.K.4    Hilsenbeck, S.G.5
  • 6
    • 0029970396 scopus 로고    scopus 로고
    • The new era in breast cancer. Invasion, size and nodal involvement dramatically decreasing as a result of mammography screening
    • Cady B, Stone MD, Schuler JG, Thakur R, Wanner MA, Lavin PT (1996) The new era in breast cancer. Invasion, size and nodal involvement dramatically decreasing as a result of mammography screening. Arch Surg 131:301-308
    • (1996) Arch Surg , vol.131 , pp. 301-308
    • Cady, B.1    Stone, M.D.2    Schuler, J.G.3    Thakur, R.4    Wanner, M.A.5    Lavin, P.T.6
  • 7
    • 0027057589 scopus 로고
    • Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections
    • Cattoretti G, Becker MH, Key G, Duchrow M, Schluter C, Galle J, Gerdes J (1992) Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:357-363
    • (1992) J Pathol , vol.168 , pp. 357-363
    • Cattoretti, G.1    Becker, M.H.2    Key, G.3    Duchrow, M.4    Schluter, C.5    Galle, J.6    Gerdes, J.7
  • 8
    • 2442684453 scopus 로고    scopus 로고
    • Ten-year outcomes in a population-based cohort of node-negative, lymphatic, and vascular invasion-negative early breast cancers without adjuvant systemic therapies
    • Chia SK, Speers CH, Bryce CJ, Hayes MM, Olivotto IA (2004) Ten-year outcomes in a population-based cohort of node-negative, lymphatic, and vascular invasion-negative early breast cancers without adjuvant systemic therapies. J Clin Oncol 22:1630-1637
    • (2004) J Clin Oncol , vol.22 , pp. 1630-1637
    • Chia, S.K.1    Speers, C.H.2    Bryce, C.J.3    Hayes, M.M.4    Olivotto, I.A.5
  • 10
    • 0028235588 scopus 로고
    • Histologic grading of breast carcinoma. a reproducibility study
    • Dalton LW, Page DL, Dupont WD (1994) Histologic grading of breast carcinoma. A reproducibility study. Cancer 73:2765-2770
    • (1994) Cancer , vol.73 , pp. 2765-2770
    • Dalton, L.W.1    Page, D.L.2    Dupont, W.D.3
  • 11
    • 0033910732 scopus 로고    scopus 로고
    • Histologic grading of breast cancer: Linkage of patient outcome with level of pathologist agreement
    • Dalton LW, Pinder SE, Elston CE, Page DL, Dupont WD, Blamey RW (2000) Histologic grading of breast cancer: linkage of patient outcome with level of pathologist agreement. Mod Pathol 13:730-735
    • (2000) Mod Pathol , vol.13 , pp. 730-735
    • Dalton, L.W.1    Pinder, S.E.2    Elston, C.E.3    Page, D.L.4    Dupont, W.D.5    Blamey, R.W.6
  • 12
    • 0022343752 scopus 로고
    • Prognostic significance of peritumoral vessel invasion in clinical trials of adjuvant therapy for breast cancer with axillary lymph node metastasis
    • Davis BW, Gelber R, Goldhirsch A, Hartmann WH, Hollaway L, Russell I, Rudenstam CM (1985) Prognostic significance of peritumoral vessel invasion in clinical trials of adjuvant therapy for breast cancer with axillary lymph node metastasis. Human Pathol 16:1212-1218
    • (1985) Human Pathol , vol.16 , pp. 1212-1218
    • Davis, B.W.1    Gelber, R.2    Goldhirsch, A.3    Hartmann, W.H.4    Hollaway, L.5    Russell, I.6    Rudenstam, C.M.7
  • 14
    • 0031949961 scopus 로고    scopus 로고
    • Randomized phase II trial of infusional fluorouracil, epirubicin and cyclophosphamide versus infusional fluorouracil, epirubicin and cisplatin in patients with advanced breast cancer
    • Eisen T, Smith IE, Johnston S, Ellis PA, Prendiville J, Seymour MT, Walsh G, Ashley S (1998) Randomized phase II trial of infusional fluorouracil, epirubicin and cyclophosphamide versus infusional fluorouracil, epirubicin and cisplatin in patients with advanced breast cancer. J Clin Oncol 16:1350-1357
    • (1998) J Clin Oncol , vol.16 , pp. 1350-1357
    • Eisen, T.1    Smith, I.E.2    Johnston, S.3    Ellis, P.A.4    Prendiville, J.5    Seymour, M.T.6    Walsh, G.7    Ashley, S.8
  • 15
    • 0026750683 scopus 로고
    • Pathological prognostic factors in breast cancer. II. Histological type. Relationship with survival in a large study with long-term follow up
    • Ellis IO, Galea M, Broughton N, Locker A, Blamey RW, Elston CW (1992) Pathological prognostic factors in breast cancer. II. Histological type. Relationship with survival in a large study with long-term follow up. Histopathology 20:479-489
    • (1992) Histopathology , vol.20 , pp. 479-489
    • Ellis, I.O.1    Galea, M.2    Broughton, N.3    Locker, A.4    Blamey, R.W.5    Elston, C.W.6
  • 16
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. the value of histological grade in breast cancer: Experience from a large study with long-term follow up
    • Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow up. Histopathology 19:403-410
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 18
  • 19
    • 0028890628 scopus 로고
    • Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma
    • Frierson HF Jr, Wolber RA, Berean KW, Franquemont DW, Gaffey MJ, Boyd JC, Wilbur DC (1995) Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma. Am J Clin Pathol 103:195-198
    • (1995) Am J Clin Pathol , vol.103 , pp. 195-198
    • Frierson Jr., H.F.1    Wolber, R.A.2    Berean, K.W.3    Franquemont, D.W.4    Gaffey, M.J.5    Boyd, J.C.6    Wilbur, D.C.7
  • 20
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, Wacker H-H, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3    Wacker, H.-H.4    Schwab, U.5    Stein, H.6
  • 21
    • 84965835332 scopus 로고
    • Varying degree of malignancy in cancer of the breast
    • Greenhough RB (1925) Varying degree of malignancy in cancer of the breast. J Cancer Res 9:453-463
    • (1925) J Cancer Res , vol.9 , pp. 453-463
    • Greenhough, R.B.1
  • 22
    • 84965276476 scopus 로고
    • The basis for histologic grading of the breast
    • Haagensen CD (1933) The basis for histologic grading of the breast. Am J Cancer 1:285-327
    • (1933) Am J Cancer , vol.1 , pp. 285-327
    • Haagensen, C.D.1
  • 23
    • 0030061315 scopus 로고    scopus 로고
    • Correlation of growth fraction by Ki-67 and proliferating cell nuclear antigen (PCNA) immunohistochemistry with histopathological parameters and prognosis in primary breast carcinomas
    • Haerslev T, Jacobsen GK, Zedeler K (1996) Correlation of growth fraction by Ki-67 and proliferating cell nuclear antigen (PCNA) immunohistochemistry with histopathological parameters and prognosis in primary breast carcinomas. Breast Cancer Res Treat 37:101-113
    • (1996) Breast Cancer Res Treat , vol.37 , pp. 101-113
    • Haerslev, T.1    Jacobsen, G.K.2    Zedeler, K.3
  • 24
    • 0026696019 scopus 로고
    • Histological grading in breast cancer. Interobserver agreement and relation to other prognostic factors including ploidy
    • Harvey JM, de Klerk NH, Sterrett GF (1992) Histological grading in breast cancer. Interobserver agreement and relation to other prognostic factors including ploidy. Pathology 24:63-68
    • (1992) Pathology , vol.24 , pp. 63-68
    • Harvey, J.M.1    De Klerk, N.H.2    Sterrett, G.F.3
  • 25
    • 0141961464 scopus 로고    scopus 로고
    • Comparison of automated cellular imaging system and manual microscopy for immunohistochemically stained cryostat sections of lung cancer specimens applying p53, Ki-67 and p120
    • Hilbe W, Gachter A, Duba HC, Dirnhofer S, Eisterer W, Schmid T, Mildner A, Bodner J, Woll E (2003) Comparison of automated cellular imaging system and manual microscopy for immunohistochemically stained cryostat sections of lung cancer specimens applying p53, Ki-67 and p120. Oncol Rep 10:15-20
    • (2003) Oncol Rep , vol.10 , pp. 15-20
    • Hilbe, W.1    Gachter, A.2    Duba, H.C.3    Dirnhofer, S.4    Eisterer, W.5    Schmid, T.6    Mildner, A.7    Bodner, J.8    Woll, E.9
  • 28
    • 0029039796 scopus 로고
    • Proliferation markers in breast carcinoma. Mitotic figure count, S-phase fraction, proliferating cell nuclear antigen, Ki-67 and MIB-1
    • Keshgegian AA, Cnaan A (1995) Proliferation markers in breast carcinoma. Mitotic figure count, S-phase fraction, proliferating cell nuclear antigen, Ki-67 and MIB-1. Am J Clin Pathol 104:42-49
    • (1995) Am J Clin Pathol , vol.104 , pp. 42-49
    • Keshgegian, A.A.1    Cnaan, A.2
  • 29
    • 0030759088 scopus 로고    scopus 로고
    • Subjective breast cancer grading. Analyses of reproducibility after application of Bayesian belief networks
    • Kronqvist P, Montironi R, Kuopio T, Collan YU (1997) Subjective breast cancer grading. Analyses of reproducibility after application of Bayesian belief networks. Anal Quant Cytol Histol 19:423-429
    • (1997) Anal Quant Cytol Histol , vol.19 , pp. 423-429
    • Kronqvist, P.1    Montironi, R.2    Kuopio, T.3    Collan, Y.U.4
  • 31
    • 0024469561 scopus 로고
    • Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas
    • Le Doussal V, Tubiana-Hulin M, Friedman S, Hacene K, Spyratos F, Brunet M (1989) Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64:1914-1921
    • (1989) Cancer , vol.64 , pp. 1914-1921
    • Le Doussal, V.1    Tubiana-Hulin, M.2    Friedman, S.3    Hacene, K.4    Spyratos, F.5    Brunet, M.6
  • 32
    • 0032739775 scopus 로고    scopus 로고
    • Assessment of proliferative activity in breast cancer: MIB-1 immunohistochemistry versus mitotic figure count
    • Lehr HA, Hansen DA, Kussick S, Li M, Hwang H, Krummenauer F, Trouet S, Gown AM (1999) Assessment of proliferative activity in breast cancer: MIB-1 immunohistochemistry versus mitotic figure count. Human Pathol 30:1314-1320
    • (1999) Human Pathol , vol.30 , pp. 1314-1320
    • Lehr, H.A.1    Hansen, D.A.2    Kussick, S.3    Li, M.4    Hwang, H.5    Krummenauer, F.6    Trouet, S.7    Gown, A.M.8
  • 35
    • 0036840908 scopus 로고    scopus 로고
    • Inter-laboratory and inter-observer reproducibility of immunohistochemical assessment of the Ki-67 labeling index in large multi-centre trial
    • Mengel M, von Wasielewski R, Wiese B, Rudiger T, Muller-Hermelink HK, Kreipe H (2002) Inter-laboratory and inter-observer reproducibility of immunohistochemical assessment of the Ki-67 labeling index in large multi-centre trial. J Pathol 198:292-299
    • (2002) J Pathol , vol.198 , pp. 292-299
    • Mengel, M.1    Von Wasielewski, R.2    Wiese, B.3    Rudiger, T.4    Muller-Hermelink, H.K.5    Kreipe, H.6
  • 36
    • 24044552649 scopus 로고    scopus 로고
    • Breast carcinoma malignancy grading by Bloom-Richardson system vs. proliferation index: Reproducibility of grade and advantages of proliferation index
    • Cooperative Breast Cancer Tissue Resource
    • Meyer JS, Alvarez C, Milikowski C, Olson N, Russo I, Russo J, Glass A, Zehnbauer BA, Lister K, Parwaresch R, Cooperative Breast Cancer Tissue Resource (2005) Breast carcinoma malignancy grading by Bloom-Richardson system vs. proliferation index: reproducibility of grade and advantages of proliferation index. Mod Pathol 18:1067-1078
    • (2005) Mod Pathol , vol.18 , pp. 1067-1078
    • Meyer, J.S.1    Alvarez, C.2    Milikowski, C.3    Olson, N.4    Russo, I.5    Russo, J.6    Glass, A.7    Zehnbauer, B.A.8    Lister, K.9    Parwaresch, R.10
  • 37
    • 0348108195 scopus 로고    scopus 로고
    • The prognostic relevance of estimates of proliferative activity in early breast cancer
    • Danish Breast Cancer Cooperative Tumour Biology Committee
    • Offersen BV, Sorensen FB, Knoop A, Overgaard J, Danish Breast Cancer Cooperative Tumour Biology Committee (2003) The prognostic relevance of estimates of proliferative activity in early breast cancer. Histopathology 43:573-582
    • (2003) Histopathology , vol.43 , pp. 573-582
    • Offersen, B.V.1    Sorensen, F.B.2    Knoop, A.3    Overgaard, J.4
  • 38
    • 0029248294 scopus 로고
    • Histologic grading of breast cancer. Let's do it
    • Page DL, Ellis IO, Elston CW (1995) Histologic grading of breast cancer. Let's do it. Am J Clin Pathol 103:123-124
    • (1995) Am J Clin Pathol , vol.103 , pp. 123-124
    • Page, D.L.1    Ellis, I.O.2    Elston, C.W.3
  • 39
    • 49749193026 scopus 로고
    • The position of histology in the prognosis of the breast
    • Patey DH, Scarff RW (1928) The position of histology in the prognosis of the breast. Lancet 1:801-804
    • (1928) Lancet , vol.1 , pp. 801-804
    • Patey, D.H.1    Scarff, R.W.2
  • 40
    • 9144242764 scopus 로고    scopus 로고
    • Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients with neoadjuvant anthracycline based chemotherapy
    • Petit T, Wilt M, Velten M, Millon R, Rodier JF, Borel C, Mors R, Haegele P, Eber M, Ghnassia JP (2004) Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients with neoadjuvant anthracycline based chemotherapy. Eur J Cancer 40:205-211
    • (2004) Eur J Cancer , vol.40 , pp. 205-211
    • Petit, T.1    Wilt, M.2    Velten, M.3    Millon, R.4    Rodier, J.F.5    Borel, C.6    Mors, R.7    Haegele, P.8    Eber, M.9    Ghnassia, J.P.10
  • 44
    • 0031007282 scopus 로고    scopus 로고
    • Prognosis of radically operated breast carcinoma patients. a retrospective study of 167 consecutive patients with emphasis on histopathological grading, reproducibility and mean nuclear area
    • Raabe NK, Schistad O, Sauer T, Bofin A, Kaaresen R, Fossaa SD (1997) Prognosis of radically operated breast carcinoma patients. A retrospective study of 167 consecutive patients with emphasis on histopathological grading, reproducibility and mean nuclear area. Acta Pathol Microbiol Immunol Scand APMIS 105:363-370
    • (1997) Acta Pathol Microbiol Immunol Scand APMIS , vol.105 , pp. 363-370
    • Raabe, N.K.1    Schistad, O.2    Sauer, T.3    Bofin, A.4    Kaaresen, R.5    Fossaa, S.D.6
  • 47
    • 0028890371 scopus 로고
    • Relationship of the size of the invasive component of the primary breast carcinoma to axillary lymph node metastasis
    • Sediman JD, Schnaper LA, Aisner SC (1995) Relationship of the size of the invasive component of the primary breast carcinoma to axillary lymph node metastasis. Cancer 75:65-71
    • (1995) Cancer , vol.75 , pp. 65-71
    • Sediman, J.D.1    Schnaper, L.A.2    Aisner, S.C.3
  • 48
    • 0033139939 scopus 로고    scopus 로고
    • Interobserver agreement of the Nottingham histologic grading scheme for infiltrating duct carcinoma breast
    • Sikka M, Agarwal S, Bhatia A (1999) Interobserver agreement of the Nottingham histologic grading scheme for infiltrating duct carcinoma breast. Indian J Cancer 36:149-153
    • (1999) Indian J Cancer , vol.36 , pp. 149-153
    • Sikka, M.1    Agarwal, S.2    Bhatia, A.3
  • 49
    • 0034524773 scopus 로고    scopus 로고
    • Does routine grading of invasive lobular cancer of the breast have the same prognostic significance as for ductal cancers?
    • Sinha PS, Bendall S, Bates T (2000) Does routine grading of invasive lobular cancer of the breast have the same prognostic significance as for ductal cancers? Eur J Surg Oncol 26:733-737
    • (2000) Eur J Surg Oncol , vol.26 , pp. 733-737
    • Sinha, P.S.1    Bendall, S.2    Bates, T.3
  • 54
    • 0025689730 scopus 로고
    • Histological grading of breast cancer. Interobserver, reproducibility and prognostic significance
    • Theissig F, Kunze KD, Haroske G, Meyer W (1990) Histological grading of breast cancer. Interobserver, reproducibility and prognostic significance. Pathol Res Pract 186:732-736
    • (1990) Pathol Res Pract , vol.186 , pp. 732-736
    • Theissig, F.1    Kunze, K.D.2    Haroske, G.3    Meyer, W.4
  • 55
    • 33746877815 scopus 로고    scopus 로고
    • The limited prognostic value of measuring and grading small invasive breast carcinomas: The whole sick lobe versus the details within it
    • Tot T (2006) The limited prognostic value of measuring and grading small invasive breast carcinomas: the whole sick lobe versus the details within it. Med Sci Monit 12:RA170-RA175
    • (2006) Med Sci Monit , vol.12
    • Tot, T.1
  • 56
    • 20244374922 scopus 로고    scopus 로고
    • Ki-67 expression in breast carcinoma. Its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker?
    • International Breast Cancer Study Group
    • Trihia H, Murray S, Price K, Gelber RD, Golouh R, Goldhirsch A, Coates AS, Collins J, Castiglione-Gertsch M, Gusterson BA, International Breast Cancer Study Group (2003) Ki-67 expression in breast carcinoma. Its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker? Cancer 97:1321-1331
    • (2003) Cancer , vol.97 , pp. 1321-1331
    • Trihia, H.1    Murray, S.2    Price, K.3    Gelber, R.D.4    Golouh, R.5    Goldhirsch, A.6    Coates, A.S.7    Collins, J.8    Castiglione-Gertsch, M.9    Gusterson, B.A.10
  • 57
    • 34447589210 scopus 로고
    • Ueber die Anaplasie der Geschwulstzellen und die asymmetrische mitose
    • Von Hansemann D (1892) Ueber die Anaplasie der Geschwulstzellen und die asymmetrische mitose. Virchows Arch Pathol Anat 129:436-449
    • (1892) Virchows Arch Pathol Anat , vol.129 , pp. 436-449
    • Von Hansemann, D.1
  • 58
    • 0035860140 scopus 로고    scopus 로고
    • Tumour markers in breast carcinoma correlate with grade rather than with invasiveness
    • Warnberg F, Nordgren H, Bergkvist L, Holmberg L (2001) Tumour markers in breast carcinoma correlate with grade rather than with invasiveness. Br J Cancer 85:869-874
    • (2001) Br J Cancer , vol.85 , pp. 869-874
    • Warnberg, F.1    Nordgren, H.2    Bergkvist, L.3    Holmberg, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.