Assessment of proliferative activity in breast cancer: MIB-1 immunohistochemistry versus mitotic figure count

Human Pathology

Volumn 30, Issue 11, 1999, Pages 1314-1320

  Lehr, H A ^a   Hansen, D A ^b   Kussick, S ^b   Li, M ^b   Hwang, H ^b   Krummenauer, F ^b   Trouet, S ^b   Gown, A M ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NONE

Author keywords

Image analysis; Interobserver correlation; Ki 67; Prognosis

Indexed keywords

KI 67 ANTIGEN;

ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER GRADING; CELL DIVISION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOSIS RATE; PROGNOSIS; TUMOR GROWTH;

EID: 0032739775     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90062-X     Document Type: Article

References (42)

1. Galea MH, Blamey RW, Elston CE, et al: The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Res Treat 22:207-219, 1992
2. Pereira H, Pinder SE, Sibbering DM, et al: Pathological prognostic factors in breast cancer. IV: Should you be a typer or a grader? A comparative study of two histological prognostic features in operable breast carcinoma. Histopathology 27:219-226, 1995
3. Patey DH, Scarff RW: The position of histology in the prognosis of carcinoma of the breast. Lancet i:801-804, 1928
4. Bloom HJG: Prognosis in carcinoma of the breast. Br J Cancer 4:259-288, 1950
5. Bloom HJG, Richardson WW: Histological grading and prognosis in breast cancer. Br J Cancer 11:359-377, 1957
6. Elston CW: The assessment of histological differentiation in breast cancer. Aust N Z J Surg 54:11-15, 1984
7. Elston CW, Ellis IO: Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology 19:403-410, 1991
8. Baak JP, van Dop H, Kurver PH, et al: The value of morphometry to classic prognosticators in breast cancer. Cancer 56:374-382, 1985
9. Linden JC van der, Baak JP, Lindeman J, et al: Prospective evaluation of the prognostic value of morphometry in primary breast cancer patients. J Clin Pathol 40:302-306, 1987
10. le Doussal V, Tubiana-Hulin M, Friedman S, et al: Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR): An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64:1914-1921, 1989
11. Uyterlinde AM, Baak JP, Schipper NW, et al: Further evaluation of the prognostic value of morphometric and flow cytometric features in breast cancer patients with long follow-up. Int J Cancer 45:1-7, 1990
12. Lipponen PK, Collan Y, Eskelinen MJ: Volume corrected mitotic index (M/V index), mitotic activity index (MAI), and histological grading in breast cancer. Int Surg 76:245-249, 1991
13. Clayton F: Pathologic correlates of survival in 378 lymph node-negative infiltrating ductal breast carcinomas: Mitotic count is the best single predictor. Cancer 68:1309-1317, 1991
14. Eskelinen M, Lipponen P, Papinaho S, et al: DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors as independent prognostic factors in female breast cancer. Int J Cancer 51:555-561, 1992
15. Keshgegian AA, Cnaan A: Proliferation markers in breast carcinoma: Mitotic figure count, S-phase fraction, proliferating cell nuclear antigen, Ki-67 and MIB-1. Am J Clin Pathol 104:42-49, 1995
16. Jannink I, van Diest PJ, Baak JP: Comparison of the prognostic value of four methods to assess mitotic activity in 186 invasive breast cancer patients: Classical and random mitotic activity assessments with correction for volume percentage of epithelium. HUM PATHOL 26:1086-1092, 1995
17. Russo J, Frederick J, Ownby HE, et al: Predictors of recurrence and survival of patients with breast cancer. Am J Clin Pathol 88:123-131, 1987
18. Aaltomaa S, Lipponen P, Eskelinen M, et al: Prognostic scores combining clinical, histological and morphometric variables in assessment of the disease outcome in female breast cancer. Int J Cancer 49:886-892, 1991
19. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715, 1984
20. Barnard NJ, Hall PA, Lemoine NR, et al: Proliferative index in breast carcinoma determined in situ by Ki-67 immunostaining and its relationship to clinical and pathological variables. J Pathol 152:287-295, 1987
21. Charpin C, Andrac L, Vacheret H, et al: Multiparametric evaluation (SAMBA) of growth fraction (monoclonal Ki-67) in breast carcinoma tissue sections. Cancer Res 48:4368-4374, 1988
22. Isola JJ, Helin HJ, Helle MJ, et al: Evaluation of cell proliferation in breast carcinoma: Comparison of Ki-67 immunohistochemical study, DNA flow cytometric analysis, and mitotic count. Cancer 65:1180-1184, 1990
23. Bilous AM, McKay M, Milliken J: A comparison between Ki-67 antibody reactivity and other pathological variables in breast carcinoma. Pathology 23:282-285, 1991
24. Locker AP, Birrell K, Bell JA, et al: Ki-67 immunoreactivity in breast carcinoma: Relationships to prognostic variables and short term survival. Eur J Surg Oncol 18:224-229, 1992
25. Pinder SE, Wencyk P, Sibbering DM, et al: Assessment of the new proliferation marker MIB-I in breast carcinoma using image analysis: Associations with other prognostic factors and survival. Br J Cancer 71:146-149, 1995
26. Bouzubar N, Walker KJ, Griffiths K, et al: Ki-67 immunostaining in primary breast cancer: Pathological and clinical associations. Br J Cancer 59:943-947, 1989
27. Nicholson RI, Bouzubar N, Walker KJ, et al: Hormone sensitivity in breast cancer: Influence of heterogeneity of oestrogen receptor expression and cell proliferation. Eur J Cancer 27:908-913, 1991
28. Sahin AA, Ro J, Ro JY, et al: Ki-67 immunostaining in node-negative stage I/II breast carcinoma: Significant correlation with prognosis. Cancer 68:549-557, 1991
29. Mir R, Johnson H, Mathur R, et al: Ki-67 reactivity in breast carcinoma analyzed by a computer-assisted image system: Preliminary results. J Natl Med Assoc 87:554-559, 1995
30. Kamel OW, Franklin WA, Ringus JC, et al: Thymidine labelling index and Ki-67 growth fractions in lesions of the breast. Am J Pathol 134:107-113, 1989
31. Raymond WA, Leong AS: Nucleolar organizer regions relate to growth fractions in human breast carcinoma. HUM PATHOL 20:741-746, 1989
32. Weidner N, Moore DH, Vartanian R: Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel "paraffin"-reactive MIB-1 antibody. HUM PATHOL 25:337-342, 1994
33. Rudolph P, Peters J, Lorenz D, et al: Correlation between mitotic and Ki-67 labeling indices in paraffin-embedded carcinoma specimens. HUM PATHOL 29:1216-1222, 1998
34. Hsu SM, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580, 1981
35. Gown AM, Vogel AM: Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am J Pathol 114:309-321, 1984
36. Gown AM, deWever N, Battifora H: Microwave-based antigenic unmasking: A revolutionary new technique for routine immunohistochemistry. Appl Immunohistochem 1:256-266, 1993
37. Lehr HA, Hansen KD, Coltrera MD, et al: Photoshop-based image analysis for the semiautomated assessment of Ki-67-defined proliferative activity in the routine diagnosis of breast cancer. Appl Immunohistochem 4:117-127, 1996
38. Lehr HA, van der Loos CM, Teeling P, et al: Complete chromogen separation and analysis in double immunohistochemical stains using Photoshop-based image analysis. J Histochem Cytochem 47:119-126, 1999
39. Donhuijsen K: Mitosis counts: Reproducibility and significance in grading of malignancy. HUM PATHOL 17:1122-1125, 1986
40. Robbins P, Pinder S, deKlerk N, et al: Histological grading of breast carcinomas: A study on interobserver agreement. HUM PATHOL 26:873-879, 1995
41. van Diest PJ, Baak JPA, Matze-Cok P, et al: Reproducibility of mitosis counting in 2,469 breast cancer specimens: Results from the Multicenter Morphometric Mammary Carcinoma project. HUM PATHOL 23:603-607, 1992
42. Donhuijsen K, Schmidt U, Hirche H, et al: Changes in mitiotic rate and cell cycle fractions caused by a delayed fixation. HUM PATHOL 21:709-714, 1990