The constrained amino acid β-Acc confers potency and selectivity to integrin ligands

Angewandte Chemie - International Edition

Volumn 46, Issue 21, 2007, Pages 3976-3978

  Urman, Sylwia ^a   Gaus, Katharina ^a   Yang, Yi ^a   Strijowski, Ulf ^a   Sewald, Norbert ^a   De Pol, Silvia ^b   Reiser, Oliver ^b  

^a BIELEFELD UNIVERSITY   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Amino acids; Conformational analysis; Integrins; Peptides; Structure activity relationships

Indexed keywords

CONFORMATIONAL ANALYSIS; INTEGRINS; RCD PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIPS;

CARBOXYLIC ACIDS; CELL ADHESION; CONFORMATIONS; ENANTIOMERS; LIGANDS; PEPTIDES;

AMINO ACIDS;

CARBOXYLIC ACID; CIS BETA AMINOCYCLOPROPANECARBOXYLIC ACID; CIS-BETA-AMINOCYCLOPROPANECARBOXYLIC ACID; CYCLOPROPANE DERIVATIVE; LIGAND; OLIGOPEPTIDE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CELL ADHESION; CELL LINE; CELL STRAIN K 562; CHEMISTRY; CONFORMATION; DRUG EFFECT; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CARBOXYLIC ACIDS; CELL ADHESION; CELL LINE; CYCLOPROPANES; HUMANS; INTEGRIN ALPHAVBETA3; K562 CELLS; LIGANDS; MOLECULAR CONFORMATION; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250770070     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200605248     Document Type: Article

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