A supramolecular approach to organic alloys: Cocrystals and three- and four-component solid solutions of 1,4-diazabicyclo[2.2.2]octane and 4-X-phenols (X = Cl, CH3, Br)

Angewandte Chemie - International Edition

Volumn 46, Issue 22, 2007, Pages 4132-4135

  Dabros, Marta ^a   Emery, Paul R ^a   Thalladi, Venkat R ^a  

^a Life Science and Bioengineering Center   (United States)

Author keywords

Crystal engineering; Organic alloys; Phenols; Solid solutions; Supramolecular chemistry

Indexed keywords

CRYSTAL ENGINEERING; CRYSTALLIZATION; PHENOLS; SOLID SOLUTIONS; SUBSTITUTION REACTIONS; SUPRAMOLECULAR CHEMISTRY;

ORGANIC ALLOYS; ORGANIC SOLIDS; SUPRAMOLECULAR ASSEMBLIES;

PARAFFINS;

EID: 34250765276     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200604830     Document Type: Article

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19. Angew. Chem. Int. Ed. 2005, 44, 7059-7062. Note, however, that the multicomponent solid solutions in this work are based on ionic components.
20. For example, solid solutions of insulin and a lipophilically modified insulin derivative show superior in vivo therapeutic properties; see: M. L. Brader, M. Sukumar, A. H. Pekar, D. S. McClellan, R. E. Chance, D. B. Flora, A. L. Cox, L. Irwin, S. R. Myers, Nat. Biotechnol. 2002, 20, 800-804. In this paper, homogeneous mixtures of insulin and its derivative are described as cocrystals. We note that these mixtures, though crystalline, are in fact members of a solid solution.
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23. 2 = 0.114. ClMeBr: Only cell parameters are reported herein (Table 1); a full structural analysis will be published elsewhere. CCDC-628798 (ClCl), CCDC-628799 (MeMe), CCDC-628800 (BrBr), CCDC-628801 (ClMe), CCDC-628802 (ClBr), and CCDC-628803 (MeBr) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
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