Impact of deletion of envelope-related genes of recombinant Sendai viruses on immune responses following pulmonary gene transfer of neonatal mice

Gene Therapy

Volumn 14, Issue 13, 2007, Pages 1017-1028

  Tanaka, S ^a,b   Yonemitsu, Y ^a   Yoshida, K ^a   Okano, S ^a   Kondo, H ^a   Inoue, M ^c   Hasegawa, M ^c   Masumoto, K ^b   Suita, S ^b   Taguchi, T ^b   Sueishi, K ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c University of Tokyo   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROLIPOAMIDE DEHYDROGENASE; GLYCINE DEHYDROGENASE (DECARBOXYLATING); GUANINE NUCLEOTIDE BINDING PROTEIN; VIRUS VECTOR;

ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG SAFETY; DRUG SYNTHESIS; FEMALE; GENE DELETION; GENE EXPRESSION; GENE TRANSFER; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; LUNG DISEASE; MORTALITY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SENDAI VIRUS; TEMPERATURE SENSITIVITY; TOXICITY TESTING; VIRAL GENE THERAPY; VIRUS RECOMBINANT; WEIGHT REDUCTION;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, VIRAL; CYTOKINES; FEMALE; GENE DELETION; GENE THERAPY; GENETIC VECTORS; INHALATION; KILLER CELLS, NATURAL; LUNG; LUNG DISEASES; MICE; MICE, INBRED STRAINS; SENDAI VIRUS; T-LYMPHOCYTES, CYTOTOXIC; TRANSDUCTION, GENETIC; VIRAL ENVELOPE PROTEINS;

MUS; SENDAI VIRUS;

EID: 34250763677     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302955     Document Type: Article

References (32)

1. Griesenbach U, Geddes DM, Alton EW. Gene therapy progress and prospects: cystic fibrosis. Gene Therapy 2006; 13: 1061-1077.
2. Tate S, Elborn S. Progress towards gene therapy for cystic fibrosis. Expert Opin Drug Deliv 2005; 2: 269-280.
3. Schwiebert LM. Cystic fibrosis, gene therapy, and lung inflammation: For better or worse? Am J Physiol Lung Cell Mol Physiol 2004; 286 L715-L716.
4. Ferrari S, Geddes DM, Alton EW. Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis. Adv Drug Deliv Rev 2002; 54: 1373-1393.
5. Kitson C, Angel B, Judd D, Rothery S, Severs NJ, Dewar A et al. The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium. Gene Ther 1999; 6: 534-546.
6. Crystal RG, Jaffe A, Brody S, Mastrangeli A, McElvaney NG, Rosenfeld M et al. A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung. Hum Gene Ther 1995; 6: 643-666.
7. Knowles MR, Noone PG, Hohneker K, Johnson LG, Boucher RC, Efthimiou J et al. A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis. Hum Gene Therapy 1998; 9: 249-269.
8. Wagner JA, Nepomuceno IB, Messner AH, Moran ML, Batson EP, Dimiceli S et al. A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum Gene Therapy 2002; 13: 1349-1359.
9. Alton EW, Stern M, Farley R, Jaffe A, Chadwick SL, Phillips J et al. Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: A double-blind placebo-controlled trial. Lancet 1999; 353: 947-954.
10. Yonemitsu Y, Kitson C, Ferrari S, Farley R, Griesenbach U, Judd D et al. Efficient gene transfer to airway epithelium using recombinant Sendai virus. Nat Biotechnol 2000; 18: 970-973.
11. Shoji F, Yonemitsu Y, Okano S, Yoshino I, Nakagawa K, Nakashima Y et al. Airway-directed gene transfer of interleukin-10 using recombinant Sendai virus effectively prevents posttransplantation bronchiolitis obliterans in mice. Gene Therapy 2003; 10: 213-218.
12. Nagai Y. Paramyxovirus replication and pathogenesis. Reverse genetics transforms understanding. Rev Med Virol 1999; 9: 83-99.
13. Markwell MA, Svennerholm L, Paulson JC. Specific gangliosides function as host cell receptors for Sendai virus. Proc Natl Acad Sci USA 1981; 78: 5406-5410.
14. Moyer SA, Baker SC, Lessard JL. Tubulin: A factor necessary for the synthesis of both Sendai virus and vesicular stomatitis virus RNAs. Proc Natl Acad Sci USA 1986; 83: 5405-5409.
15. Li HO, Zhu YF, Asakawa M, Kuma H, Hirata T, Ueda Y et al. A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression. J Virol 2000; 74: 6564-6569.
16. Waddington SN, Buckley SM, Bernloehr C, Bossow S, Ungerechts G, Cook T et al. Reduced toxicity of F-deficient Sendai virus vector in the mouse fetus. Gene Therapy 2004; 11: 599-608.
17. Larson JE, Cohen JC. Developmental paradigm for early features of cystic fibrosis. Pediatr Pulmonol 2005; 40: 371-377.
18. Inoue M, Tokusumi Y, Ban H, Kanaya T, Tokusumi T, Nagai Y et al. Nontransmissible virus-like particle formation by F-deficient Sendai virus is temperature sensitive and reduced by mutations in M and HN proteins. J Virol 2003; 77: 3238-3246.
19. Inoue M, Tokusumi Y, Ban H, Kato A, Nagai Y, Iida A et al. Further attenuation of gene(s)-deleted Sendai virus vectors: Modification of transcription and replication caused weakened cytotoxicity. Mol Ther 2003; 7(Suppl): S37 (Abstr).
20. Yoshizaki M, Hironaka T, Iwasaki H, Ban H, Tokusumi Y, Iida A et al. Naked Sendai virus vector lacking all of the envelope-related genes: reduced cytopathogenicity and immunogenicity. J Gene Med 2006; 8: 1151-1159.
21. Georgeson GD, Szony BJ, Streitman K, Kovacs A, Kovacs L, Laszlo A. Natural killer cell cytotoxicity is deficient in newborns with sepsis and recurrent infections. Eur J Pediatr 2001; 160: 478-482.
22. Tessier P, Naccache P, Clark-Lewis I, Gladue R, Neote K, McColl S. Chemokine networks in vivo: Involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-α. Immunol 1997; 159: 3595-3602.
23. Frevert CW, Huang S, Danaee H, Paulauskis JD, Kobzik L. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. Immunol 1995; 154: 335-344.
24. Adkins B. T-cell function in newborn mice and humans. Immunol Today 1999; 20: 330-335.
25. Kaplan J, Shope TC, Bollinger RO, Smith J. Human newborns are deficient in natural killer activity. J Clin Immunol 1982; 2: 350-355.
26. Gasparoni A, Ciardelli L, Avanzini A, Castellazzi AM, Carini R, Rondini G et al. Age-related changes in intracellular TH1/TH2 cytokine production, immunoproliferative T lymphocyte response and natural killer cell activity in newborns, children and adults. Biol Neonate 2003; 84: 297-303.
27. Cole GA, Hogg TL, Woodland DL. T cell recognition of the immunodominant Sendai virus NP324-332/Kb epitope is focused on the center of the peptide. Immunol 1995; 155: 2841-2848.
28. Schnell MA, Zhang Y, Tazelaar J, Gao GP, Yu QC, Qian R et al. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther 2001; 3: 708-722.
29. Yonemitsu Y, Kaneda Y. Hemagglutinating virus of Japan-liposome-mediated gene delivery to vascular cells.In: Baker AH (ed). Molecular Biology of Vascular Diseases Methods in Molecular Medicine. Humana Press, Totowa, NJ, 1999, pp 295-306.
30. Yonemitsu Y, Kaneda Y, Morishita R, Nakagawa K, Nakashima Y, Sueishi K. Characterization of in vivo gene transfer into the arterial wall mediated by the HVJ-liposomes: An effective tool for in vivo study of arterial diseases. Lab Invest 1996; 75: 313-323.
31. Shibata S, Okano S, Yonemitsu Y, Onimaru M, Sata S, Nagata-Takeshita H et al. Induction of efficient antitumor immunity using dendritic cells activated by Sendai virus and its modulation of exogenous interferon-β gene. Immunol 2006; 177: 3564-3576.
32. Kast WM, Bluestone JA, Heemskerk MH, Spaargaren J, Voordouw AC, Ellenhorn JD et al. Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells. Immunol 1990; 145: 2254-2259.