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For the racemic total synthesis of cylindrospermopsin and its C-7 isomer, see: (a) Xie, C.; Runnegar, M. T. C.; Snider, B. B. J. Am. Chem. Soc. 2000, 122, 5017.
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For the enantioselective total synthesis of cylindrospermopsin and its C-7 isomer, see: (a) White, J. D.; Hansen, J. D. J. Am. Chem. Soc. 2002, 124, 4950.
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2 displacement of the bromide derivative by the guanydyl derivative in order to form cycle B of cylindrospermeopsin has been described, see reference 6a.
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2 displacement of the bromide derivative by the guanydyl derivative in order to form cycle B of cylindrospermeopsin has been described, see reference 6a.
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