Solid phase extraction as a faster alternative to HPLC: Application to MS analysis of metabolic stability samples

Journal of Pharmaceutical Sciences

Volumn 96, Issue 6, 2007, Pages 1619-1624

  Inman, Brittany L ^a   Chovan, Linda E ^a   Dandliker, Peter J ^a   Yau, Yi Lau ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ADME; Hepatic metabolism; High throughput technologies; HPLC; Mass spectrometry (MS); Microsomes; Solid phase extraction (SPE); Stability

Indexed keywords

ACETIC ACID; ACETONITRILE; AMMONIUM ACETATE; BUSPIRONE; PROPRANOLOL; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TERFENADINE;

ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; LIVER METABOLISM; LIVER MICROSOME; MASS SPECTROMETRY; METABOLIC BALANCE; NONHUMAN; SOLID PHASE EXTRACTION;

EID: 34250705769     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20788     Document Type: Article

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