Specific interaction of HeLa cell proteins with coxsackievirus B3 3′UTR: La autoantigen binds the 3′ and 5′UTR independently of the poly(A) tail

Cellular Microbiology

Volumn 9, Issue 7, 2007, Pages 1705-1715

  Cheung, Paul ^a   Lim, Travis ^a   Yuan, Jane ^a   Zhang, Mary ^a   Chau, David ^a   Mcmanus, Bruce ^a   Yang, Decheng ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; LA ANTIBODY; LA ANTIGEN; POLYADENYLIC ACID; RECOMBINANT PROTEIN; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CONTROLLED STUDY; COXSACKIE VIRUS B; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR CLONING; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; VIRUS REPLICATION;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; AUTOANTIGENS; BASE SEQUENCE; BINDING SITES; CROSS-LINKING REAGENTS; ENTEROVIRUS B, HUMAN; HELA CELLS; HUMANS; POLY A; PROTEINS; RIBONUCLEOPROTEINS; RNA-BINDING PROTEINS;

COXSACKIEVIRUS; RNA VIRUSES;

EID: 34250704896     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2007.00904.x     Document Type: Article

References (44)

1. Alvarez, D.E., De Lella Ezcurra, A.L., Fucito, S., and Gamarnik, A.V. (2005) Role of RNA structures present at the 3′UTR of dengue virus on translation, RNA synthesis, and viral replication. Virology 339: 200-212.
2. Andino, R., Boddeker, N., Silvera, D., and Gamarnik, A.V. (1999) Intracellular determinants of picornavirus replication. Trends Microbiol 7: 76-82.
3. Bell, Y.C., Semler, B.L., and Ehrenfeld, E. (1999) Requirements for RNA replication of a poliovirus replicon by coxsackievirus B3 RNA polymerase. J Virol 73: 9413-9421.
4. Belsham, G.J., and Sonenberg, N. (2000) Picornavirus RNA translation: roles for cellular proteins. Trends Microbiol 8: 330-335.
5. Bhattacharyya, S., and Das, S. (2005) Mapping of secondary structure of the spacer region within the 5′-untranslated region of the coxsackievirus B3 RNA: Possible role of an apical GAGA loop in binding La protein and influencing internal initiation of translation. Virus Res 108: 89-100.
6. Bushell, M., and Sarnow, P. (2002) Hijacking the translation apparatus by RNA viruses. J Cell Biol 158: 395-399.
7. Carthy, C.M., Yang, D., Anderson, D.R., Wilson, J.E., and McManus, B.M. (1997) Myocarditis as systemic disease: New perspectives on pathogenesis. Clin Exp Pharmacol Physiol 24: 997-1003.
8. Cheung, P., Zhang, M., Yuan, J., Chau, D., Yanagawa, B., McManus, B., and Yang, D. (2002) Specific interactions of HeLa cell proteins with Coxsackievirus B3 RNA: La autoantigen binds differentially to multiple sites within the 5′ untranslated region. Virus Res 90: 23-36.
9. Chiu, W.W., Kinney, R.M., and Dreher, T.W. (2005) Control of translation by the 5′- and 3′-terminal regions of the dengue virus genome. J Virol 79: 8303-8315.
10. Chow, L.H., Beisel, K.W., and McManus, B.M. (1992) Enteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury. Lab Invest 66: 24-31.
11. Craig, A.W., Svitkin, Y.V., Lee, H.S., Belsham, G.J., and Sonenberg, N. (1997) The La autoantigen contains a dimerization domain that is essential for enhancing translation. Mol Cell Biol 17: 163-169.
12. Crosio, C., Boyl, P.P., Loreni, F., Pierandrei-Amaldi, P., and Amaldi, F. (2000) La protein has a positive effect on the translation of TOP mRNAs in vivo. Nucleic Acids Res 28: 2927-2934.
13. Decker, C.J., and Parker, R. (1993) A turnover pathway for both stable and unstable mRNAs in yeast: Evidence for a requirement for deadenylation. Genes Dev 7: 1632-1643.
14. Domitrovich, A.M., Diebel, K.W., Ali, N., Sarker, S., and Siddiqui, A. (2005) Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication. Virology 335: 72-86.
15. Ehlers, I., Horke, S., Reumann, K., Rang, A., Grosse, F., Will, H., and Heise, T. (2004) Functional characterization of the interaction between human La and hepatitis B virus RNA. J Biol Chem 279: 43437-43447.
16. Frankel, A.D., Mattaj, I.W., and Rio, D.C. (1991) RNA-protein interactions. Cell 67: 1041-1046.
17. Grist, N.R., and Reid, D. (1993) Epidemiology of the viral infections of the heart. In Viral Infections of the Heart. Banatvala, J.E. (ed.). London: Edward Arnold, pp. 23-31.
18. Hardy, R.W., and Rice, C.M. (2005) Requirements at the 3′ end of the sindbis virus genome for efficient synthesis of minus-strand RNA. J Virol 79: 4630-4639.
19. Hellen, C.U.T., and Wimmer, E. (1995) Enterovirus genetics. In Human Enterovirus Infections. Robert, H.A. (ed.). Washington, DC: American Society for Microbiology Press, pp. 25-72.
20. Hsue, B., and Masters, P.S. (1997) A bulged stem-loop structure in the 3′ untranslated region of the genome of the coronavirus mouse hepatitis virus is essential for replication. J Virol 71: 7567-7578.
21. Huang, P., and Lai, M.M. (2001) Heterogeneous nuclear ribonucleoprotein a1 binds to the 3′-untranslated region and mediates potential 5′-3′-end cross talks of mouse hepatitis virus RNA. J Virol 75: 5009-5017.
22. Huber, S.A., Gauntt, C.J., and Sakkinen, P. (1998) Enteroviruses and myocarditis: Viral pathogenesis through replication, cytokine induction, and immunopathogenicity. Adv Virus Res 51: 35-80.
23. Jacobson, A. (1996) Poly(A) metabolism and translation: The closed-loop model. In Translation Control. Hershey, J.W.B., Mathews, M.B., and Sonenberg, N. (eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 451-479.
24. Jacobson, A., and Peltz, S.W. (1996) Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem 65: 693-739.
25. Jacobson, S.J., Konings, D.A., and Sarnow, P. (1993) Biochemical and genetic evidence for a pseudoknot structure at the 3′ terminus of the poliovirus RNA genome and its role in viral RNA amplification. J Virol 67: 2961-2971.
26. Kerekatte, V., Keiper, B.D., Badorff, C., Cai, A., Knowlton, K.U., and Rhoads, R.E. (1999) Cleavage of poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: Another mechanism for host protein synthesis shutoff? J Virol 73: 709-717.
27. Klump, W.M., Bergmann, I., Muller, B.C., Ameis, D., and Kandolf, R. (1990) Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA: Two initial 5′ uridine residues are regained during plus-strand RNA synthesis. J Virol 64: 1573-1583.
28. Kolupaeva, V.G., Hellen, C.U., and Shatsky, I.N. (1996) Structural analysis of the interaction of the pyrimidine tract-binding protein with the internal ribosomal entry site of encephalomyocarditis virus and foot-and-mouth disease virus RNAs. RNA 2: 1199-1212.
29. Kolupaeva, V.G., Pestova, T.V., Hellen, C.U., and Shatsky, I.N. (1998) Translation eukaryotic initiation factor 4G recognizes a specific structural element within the internal ribosome entry site of encephalomyocarditis virus RNA. J Biol Chem 273: 18599-18604.
30. Lama, J., Sanz, M.A., and Rodriguez, P.L. (1995) A role for 3AB protein in poliovirus genome replication. J Biol Chem 270: 14430-14438.
31. Liebig, H.D., Ziegler, E., Yan, R., Hartmuth, K., Klump, H., Kowalski, H., et al. (1993) Purification of two picornaviral 2A proteinases: Interaction with eIF-4 gamma and influence on in vitro translation. Biochemistry 32: 7581-7588.
32. Liu, Z., Carthy, C.M., Cheung, P., Bohunek, L., Wilson, J.E., McManus, B.M., and Yang, D. (1999) Structural and functional analysis of the 5′ untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants. Virology 265: 206-217.
33. Melchers, W.J., Hoenderop, J.G., Bruins Slot, H.J., Pleij, C.W., Pilipenko, E.V., Agol, V.I., and Galama, J.M. (1997) Kissing of the two predominant hairpin loops in the coxsackie B virus 3′ untranslated region is the essential structural feature of the origin of replication required for negative-strand RNA synthesis. J Virol 71: 686-696.
34. Mellits, K.H., Meredith, J.M., Rohll, J.B., Evans, D.J., and Almond, J.W. (1998) Binding of a cellular factor to the 3′ untranslated region of the RNA genomes of entero- and rhinoviruses plays a role in virus replication. J Gen Virol 79: 1715-1723.
35. Mirmomeni, M.H., Hughes, P.J., and Stanway, G. (1997) An RNA tertiary structure in the 3′ untranslated region of enteroviruses is necessary for efficient replication. J Virol 71: 2363-2370.
36. van Ooij, M.J., Glaudemans, D.H., Heus, H.A., van Kuppeveld, F.J., and Melchers, W.J. (2006) Structural and functional integrity of the coxsackievirus B3 oriR: Spacing between coaxial RNA helices. J Gen Virol 87: 689-695.
37. Pilipenko, E.V., Maslova, S.V., Sinyakov, A.N., and Agol, V.I. (1992) Towards identification of cis-acting elements involved in the replication of enterovirus and rhinovirus RNAs: A proposal for the existence of tRNA-like terminal structures. Nucleic Acids Res 20: 1739-1745.
38. Ray, P.S., and Das, S. (2002) La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA. Nucleic Acids Res 30: 4500-4508.
39. Rohll, J.B., Moon, D.H., Evans, D.J., and Almond, J.W. (1995) The 3′ untranslated region of picornavirus RNA: Features required for efficient genome replication. J Virol 69: 7835-7844.
40. Stefano, J.E. (1984) Purified lupus antigen La recognizes an oligouridylate stretch common to the 3′ termini of RNA polymerase III transcripts. Cell 36: 145-154.
41. Teplova, M., Yuan, Y.R., Phan, A.T., Malinina, L., Ilin, S., Teplov, A., and Patel, D.J. (2006) Structural basis for recognition and sequestration of UUU(OH) 3′ temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell 21: 75-85.
42. Yang, D., Wilson, J.E., Anderson, D.R., Bohunek, L., Cordeiro, C., Kandolf, R., and McManus, B.M. (1997) In vitro mutational and inhibitory analysis of the cis-acting translational elements within the 5′ untranslated region of coxsackievirus B3: Potential targets for antiviral action of antisense oligomers. Virology 228: 63-73.
43. Yu, L., and Markoff, L. (2005) The topology of bulges in the long stem of the flavivirus 3′ stem-loop is a major determinant of RNA replication competence. J Virol 79: 2309-2324.
44. Zuker, M. (1989) On finding all suboptimal foldings of an RNA molecule. Science 244: 48-52.