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Mulligan K, Parker RA, Komarow L, et al. Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial. J Acquir Immune Defic Syndr 2006; 41:590-597. A key paper that utilizes body composition data from the ACTG 384 study (zidovudine versus stavudine; nelfinavir versus efavirenz) to show that there was no evidence that central fat accumulation and peripheral fat loss are linked in most patients.
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Law M, Puls R, Cheng AK, et al. Evaluation of the HIV lipodystrophy case definition in a placebo-controlled, 144-week study in antiretroviral-naive adults. Antivir Ther 2006; 11:179-186. This study applied the HIV Lipodystrophy Case Definition to data from the Gilead 903 study to show that lipodystrophy (particularly moderate-to-severe grade) was strongly and specifically associated with stavudine therapy in protease inhibitor-naïve patients.
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Frayn KN, Arner P, Yki-Jarvinen H. Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays Biochem 2006; 42:89-103. An informative review emphasizing the dynamic nature of fatty acid metabolism, and the role of adipose tissue in this process, in health and disease.
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Demonstration of the differential functions of adipocytes and adipose tissue macrophages in secreting adipocytokines
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Podzamczer D, Ferrer E, Sanchez P, et al. Less lipoatrophy and better lipid profile with abacavir as compared to stavudine: 96-week results of a randomized study. J Acquir Immune Defic Syndr 2007; 44:139-147. Very recent report of an important clinical trial, comparing abacavir versus stavudine treatment (in protease inhibitor-naïve patients) with lipodystrophy outcomes as prominent study endpoints.
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