Study of the expressions of p53 and bcl-2 genes, the telomerase activity and apoptosis in GIST patients

World Journal of Gastroenterology

Volumn 13, Issue 18, 2007, Pages 2626-2628

  Wang, Qiang ^a   Kou, You Wei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; bcl 2; Gastrointestinal stromal tumors; p53; Telomerase

Indexed keywords

PROTEIN BCL 2; PROTEIN P53; TELOMERASE;

ADULT; APOPTOSIS; ARTICLE; BENIGN TUMOR; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENE CONTROL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT NEOPLASTIC DISEASE; NICK END LABELING; PROGNOSIS; PROTEIN EXPRESSION; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

EID: 34250654931     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i18.2626     Document Type: Article

References (31)

1. Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol 1983; 7: 507-519
2. Wan DS. Improve the diagnosis and treatment of gastric stromal tumors. Zhonghua Weichang Waike Zazhi 2003; 6: 285-287 3
3. Wan DS, Wu XJ, Liang XM, Luo RZ, Pan ZZ, Chen G, Lu ZH, Ding PR. Surgery treatment of gastric stromal tumors. Zhonghua Weichang Waike Zazhi 2003; 6: 292-294
4. Zhang CW, Zhao DJ, Zhou SC, Qiu HS. Diagnosis and treatment of gastric stromal tumors. Zhonghua Weichang Waike Zazhi 2003; 6: 288-291
5. Zhang S, Wan DS. Progress of gastric stromal tumors diagnosis and treatment. Zhonghua Weichang Waike Zazhi 2003; 6: 347-349
6. Yan H, Marchettini P, Acherman YI, Gething SA, Brun E, Sugarbaker PH. Prognostic assessment of gastrointestinal stromal tumor. Am J Clin Oncol 2003; 26: 221-228
7. Kitamura Y, Hirota S, Nishida T. Gastrointestinal stromal tumors (GIST): a model for molecule-based diagnosis and treatment of solid tumors. Cancer Sci 2003; 94: 315-320
8. Ji XL, Zhao HL. New recognization of gastrointestial stromal tumors. Shijie Huaren Xiaohua Zazhi 1998; 6; 625-627
9. Fang XM, Yu JP, Luo HS. The relationship of hTeRT, P16 expression and telomerase activity in carcinoma of large intestine. Shijie Huaren Xiaohua Zazhi 2002; 10: 12-14
10. Yang SM, Fang DQ, Yang JL, Luo YH, Lu R, Liu WW. The effect of hTRT antisense gene on expression of gastric cancer telomerase and apoptosis related genes. Shijie Huaren Xiaohua Zazhi 2002; 10: 149-152
11. Li GX, Li GQ, Zhao CZ, Xu GL. the relationship of telomerase hTRT and antioncogene P53 and P16 expression in gastric cancer. Shijie Huaren Xiaohua Zazhi 2002; 10: 591-593
12. Yu HS, Zheng GS, Sun JZ, Gao QA, Xu YX, Liu HL, Li H, Ren DX, Li SM, Huang MZ. the significance of telomerse detection in esophagus precancerous lesion. Shijie Huaren Xiaohua Zazhi 2003; 11: 342-343
13. Kim NW. Clinical implications of telomerase in cancer. Eur J Cancer 1997; 33: 781-786
14. Dahse R, Fiedler W, Ernst G. Telomeres and telomerase: biological and clinical importance. Clin Chem 1997; 43: 708-714
15. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787-791
16. Zakian VA. Life and cancer without telomerase. Cell 1997; 91: 1-3
17. Ma JP, Zhan WH. Telomeres and telomerase in gastrointestinal cancer. Guowai Yixue Waike Fence 1997; 14: 194-196
18. Nowak J, Januszkiewicz D, Lewandowski K, Nowicka-Kujawska K, Pernak M, Rembowska J, Nowak T, Wysocki J. Activity and expression of human telomerase in normal and malignant cells in gastric and colon cancer patients. Eur J Gastroenterol Hepatol 2003; 15: 75-80
19. Usselmann B, Newbold M, Morris AG, Nwokolo CU. Telomerase activity and patient survival after surgery for gastric and oesophageal cancer. Eur J Gastroenterol Hepatol 2001; 13: 903-908
20. Goytisolo FA, Samper E, Martin-Caballero J, Finnon P, Herrera E, Flores JM, Bouffler SD, Blasco MA. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med 2000; 192: 1625-1636
21. Mandal M, Kumar R. Bcl-2 modulates telomerase activity. J Biol Chem 1997; 272: 14183-14187
22. Milas M, Yu D, Sun D, Pollock RE. Telomerase activity of sarcoma cell lines and fibroblasts is independent of p53 status. Clin Cancer Res 1998; 4: 1573-1579
23. Oishi T, Kigawa J, Minagawa Y, Shimada M, Takahashi M, Terakawa N. Alteration of telomerase activity associated with development and extension of epithelial ovarian cancer. Obstet Gynecol 1998; 91: 568-571
24. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501
25. Terada T, Nakanuma Y. Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development. Am J Pathol 1995; 146: 67-74
26. Tong J, Hu GL, Fan XG, Tan DM. The effect of hepatitis c viruses nuclei protein and apoptosis on HepG2 cellcycle. Shijie Huaren Xiaohua Zazhi 2003; 11: 350-352
27. Liu HF, Liu WW, Fang DQ, Gao JH, Wang ZH. HP induced gastric epithelial cell apoptosis, hypertrophy and P53 expression. Shijie Huaren Xiaohua Zazhi 2001; 9: 1265-1268
28. Pan CJ, Liu KY. Gastric cancer hypertrophy, apoptosis and expression of contral genes. Shijie Huaren Xiaohua Zazhi 2003; 11: 526-530
29. Wang JM, Zhou Q, Zhou SQ. Apoptosis of hepatocytes in rat of obstructive jaundice and expression of apoptotic related genes bcl-2 and bax. Zhonghua Shiyan Waike Zazhi 2000; 17: 32-33
30. Yuan RW, Ding Q, Jiang HY. Pancrease cancer Bcl-2, Bax expression and cell apoptosis. Shijie Huaren Xiaohua Zazhi 1999; 7: 851-854
31. Wright WE, Brasiskyte D, Piatyszek MA, Shay JW. Experimental elongation of telomeres extends the lifespan of immortal normal cell hybrids. EMBO J 1996; 15: 1734-1741