Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein

Journal of Biochemistry

Volumn 140, Issue 6, 2006, Pages 843-849

  Kamiya, Hiroyuki ^a   Cadena Amaro, Claudio ^b   Dugué, Laurence ^b   Yakushiji, Hiroyuki ^c   Minakawa, Noriaki ^a   Matsuda, Akira ^a   Pochet, Sylvie ^b   Nakabeppu, Yusaku ^c   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b INSTITUT PASTEUR   (France)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

FAPY dGTP; MTH1; Nucleotide analog; Oxidized nucleotide; Substrate recognition

Indexed keywords

1 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 2,3 DIHYDRO 2 OXO IMIDAZOLE 4 CARBOXAMIDE 5' TRIPHOSPHATE; 7,8 DIHYDRO 8 OXO 2' DEOXYADENOSINE 5' TRIPHOSPHATE; 7,8 DIHYDRO 8 OXO 2' DEOXYGUANOSINE 5' TRIPHOSPHATE; N6 (2 DEOXY ALPHA,BETA DEXTRO RIBOFURANOSYL) 2,6 DIAMINO 5 FORMAMIDO 4 HYDROXYPYRIMIDINE 5' TRIPHOSPHATE; NUCLEOTIDE DERIVATIVE; PROTEIN; PROTEIN MTH1; UNCLASSIFIED DRUG; 1 (2 DEOXYRIBOFURANOSYL) 2,3 DIHYDRO 2 OXOIMIDAZOLE 4 CARBOXAMIDE 5' TRIPHOSPHATE; 1-(2-DEOXYRIBOFURANOSYL)-2,3-DIHYDRO-2-OXOIMIDAZOLE-4-CARBOXAMIDE 5'-TRIPHOSPHATE; 2 AMINO 9 (2 DEOXYRIBOFURANOSYL) 7,8 DIHYDRO 8 OXOPURINE 5' TRIPHOSPHATE; 2-AMINO-9-(2-DEOXYRIBOFURANOSYL)-7,8-DIHYDRO-8-OXOPURINE 5'-TRIPHOSPHATE; 8 OXODGTPASE; 8-OXODGTPASE; DEOXYADENOSINE PHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DEOXYRIBONUCLEOTIDE; IMIDAZOLE DERIVATIVE; N6 (2 DEOXYRIBOFURANOSYL) 2,6 DIAMINO 5 FORMAMIDO 4 HYDROXYPYRIMIDINE 5' TRIPHOSPHATE; N6-(2-DEOXYRIBOFURANOSYL)-2,6-DIAMINO-5-FORMAMIDO-4-HYDROXYPYRIMIDINE 5'-TRIPHOSPHATE; PHOSPHATASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; CHEMICAL STRUCTURE; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; STRUCTURE ANALYSIS; SYNTHESIS; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

DEOXYADENINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DEOXYRIBONUCLEOTIDES; DNA REPAIR ENZYMES; HUMANS; IMIDAZOLES; PHOSPHORIC MONOESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 34250650140     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj214     Document Type: Article

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