Stevens-Johnson syndrome due to concomitant use of lamotrigine and valproic acid

American Journal of Clinical Dermatology

Volumn 8, Issue 2, 2007, Pages 107-111

  Kocak, Sedat ^a   Girisgin, Sadik A ^a   Gul, Mehmet ^a   Cander, Basar ^a   Kaya, Halil ^a   Kaya, Esengul ^a  

^a SELCUK UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; CARBAMAZEPINE; CARBOMER; CHLORHEXIDINE GLUCONATE; CIPROFLOXACIN; DIAZEPAM; HYDROCORTISONE ACETATE; HYDROXYPROPYLMETHYLCELLULOSE; INFUSION FLUID; LAMOTRIGINE; MANNITOL; METHYLPREDNISOLONE; NYSTATIN; PHENIRAMINE MALEATE; THIOMERSAL; TOBRAMYCIN SULFATE; VALPROIC ACID; ANTICONVULSIVE AGENT; TRIAZINE DERIVATIVE;

ADULT; ANTICONVULSANT THERAPY; ARTICLE; CASE REPORT; CONSENSUS; CONSULTATION; CONVALESCENCE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; EMERGENCY HEALTH SERVICE; EPILEPSY; ERYTHEMA; EYELID DISEASE; FEMALE; FEVER; FOLLOW UP; HUMAN; IDIOPATHIC DISEASE; INTENSIVE CARE UNIT; MOUTH LESION; PATIENT REFERRAL; PRIORITY JOURNAL; RASH; STEVENS JOHNSON SYNDROME; URINARY TRACT INFECTION; VAGINA MUCOSA; WEAKNESS; WOUND; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; HUMANS; STEVENS-JOHNSON SYNDROME; TRIAZINES; VALPROIC ACID;

EID: 34250638749     PISSN: 11750561     EISSN: None     Source Type: Journal    
DOI: 10.2165/00128071-200708020-00007     Document Type: Article

References (29)

1. Bastuji-Garin S, Rzany B, Stern RS, et al. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol 1993; 129: 92-6
2. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994 Nov; 19 (331): 1272-85
3. Chan HL, Stern RS, Arndt KA, et al. The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: a population-based study with particular reference to reactions caused by drugs among outpatients. Arch Dermatol 1990; 126: 43-7
4. Rzany B, Correia O, Kelly JP, et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Study Group of the International Case-Control Study on Severe Cutaneous Adverse Reactions. Lancet 1999 Jun 26; 353 (9171): 2190-4
5. Strom BL, Carson JL, Halpern AC, et al. A population-based study of Stevens-Johnson syndrome: incidence and antecedent drug exposures. Arch Dermatol 1991; 127: 831-8
6. Ghislain PD, Roujeau JC. Treatment of severe drug reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome. Dermatol Online J 2002; 8 (1): 5 [online]. Available from URL: http://dermatology.c-dlib.org/DOJvol8num1/reviews/drugrxn/ghislain.html [Accessed 2007 Mar 22]
7. Arroyo S, de la Morena A. Life-threatening adverse events of antiepileptic drugs. Epilepsy Res 2001 Nov; 47 (1-2): 155-74
8. Auquier-Dunant A, Mockenhaupt M, Naldi L, et al. Correlations between causes of erythema multiforme majus, Stevens-Johnson Syndrome, and toxic epidermal necrolysis: results of an international prospective study. Arch Dermatol 2002; 138: 1019-24
9. Mockenhaupt M, Norgauer J. Cutaneous adverse drug reactions: Stevens-Johnson syndrome and toxic epidermal necrolysis. Allergy Clin Immunol Int 2002; 14: 143-50
10. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45
11. Mockenhaupt M, Messenheimer J, Tennis P, et al. Risk for Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs in Germany. Neurology 2005; 64: 1134-8
12. Sladden M, Mortimer N, Chave T. Toxic epidermal caused by lamotrigine. Aust Fam Physician 2004 Oct; 33 (10): 829-30
13. Lofton AL, Klein-Schwartz W. Evaluation of lamotrigine toxicity reported to poison centers. Ann Pharmacother 2004 Nov; 38 (11): 1811-5
14. Mockenhaupt M, Dunant A, Sidoroff A, et al. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): the risk of antiepileptic drugs. Annual Meeting of the Society for Investigative Dermatology (SID); 2003 Apr 30-May 4; Miami Beach (FL)
15. Schlienger RG, Shapiro LE, Shear NH. Lamotrigine-induced severe cutaneous adverse reactions. Epilepsia 1998; 39 Suppl. 7: S22-6
16. Messenheimer J, Mullens EL, Giorgi L, et al. Safety review of adult clinical trial experience with lamotrigine. Drug Saf 1998 Apr; 18 (4): 281-96
17. Yalcin B, Karaduman A. Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. J Am Acad Dermatol 2000 Nov; 43 (5 Pt 2): 898-9
18. Beerhorst K, Renier WO. Toxic epidermal necrolysis due to lamotrigine. Ned Tijdschr Geneeskd 2003 Jun 7; 147 (23): 1128-31
19. Bocquet H, Farmer M, Bressieux JM, et al. Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine. Ann Dermatol Venereol 1999 Jan; 126 (1): 46-8
20. Li LM, Russo M, O'Donoghue MF, et al. Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk. Arq Neuropsiquiatr 1996 Mar; 54 (1): 47-9
21. Sachs B, Ronnau AC, von Schmiedeberg S, et al. Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro. Dermatology 1997; 195 (1): 60-4
22. Anderson GD, Yau MK, Gidal BE, et al. Bidirectional interaction of valproate and lamotrigine in healthy subjects. Clin Pharmacol Ther 1996 Aug; 60 (2): 145-56
23. Page RL, O'Neil MG, Yarbrough DR, et al. Fatal toxic epidermal necrolysis related to lamotrigine administration. Pharmacotherapy 1998 Mar-Apr; 18 (2): 392-8
24. Zachariae CO, Fogh K. Toxic epidermal necrolysis after treatment with lamotrigine. Ugeskr Laeger 1998 Nov; 160 (46): 6656-7
25. Famularo G, De Simone C, Minisola G. Stevens-Johnson syndrome associated with single high dose of lamotrigine in a patient taking valproate. Dermatol Online J 2005; 11 (1): 25 [online]. Available from URL: http://dermatology.c- dlib.org/111/correspondence/lamotrigine/famularo.html [Accessed 2007 Mar 22]
26. Faught E, Morris G, Jacobson M, et al. Adding lamotrigine to valproate: incidence of rash and other adverse effects: Postmarketing Antiepileptic Drug Survey (PADS) group. Epilepsia 1999 Aug; 40 (8): 1135-40
27. Wong IC, Mawer GE, Sander JW. Factors influencing the incidence of lamotrigine-related skin rash. Ann Pharmacother 1999 Oct; 33 (10): 1037-42
28. Kaminow L, Schimschock JR, Hammer AE, et al. Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. Epilepsy 2003 Dec; 4 (6): 659-66
29. Lamotrigine [online]. Available from URL: http://www.drugguide.com/ monograph_library/psychotropic_drugs/lamotrigine.htm [Accessed 2007 Mar 22]