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Early cleavage after treatment of the resin-bound active ester group with amine was checked by analysis of filtrate, resulting in complete stability of the resin-bound compound to this reaction step. It was supposed that the resistance of resin-bound product to early cleavage by amine treatment was mainly due to the amount of amine used in the two steps, as in the amidation reaction only 5 equiv. were used, whereas in the cleavage the amount of amine was raised to 110 equiv
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