Psoralen and isopsoralen, two coumarins of psoraleae fructus, can alleviate scopolamine-induced amnesia in rats

Planta Medica

Volumn 73, Issue 3, 2007, Pages 275-278

  Wu, Chi Rei ^a   Chang, Chia Lin ^a   Hsieh, Ping Ying ^a   Lin, Li Wei ^a   Ching, Hui ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Taichung Hospital   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ANGELICIN; COUMARIN DERIVATIVE; PLANT EXTRACT; PSORALEA CORYLIFOLIA EXTRACT; PSORALEN; SCOPOLAMINE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; MAZE TEST; NONHUMAN; PSORALEA; RAT;

AMNESIA; ANIMALS; BEHAVIOR, ANIMAL; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FICUSIN; MAZE LEARNING; PHYTOTHERAPY; PLANT EXTRACTS; PSORALEA; PSORALENS; RATS; SCOPOLAMINE;

RATTUS;

EID: 34250366271     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-967127     Document Type: Article

References (19)

1. Mar W, Je KH, Seo EK. Cytotoxic constituents of Psoralea corylifolia. Arch Pharm Res 2001; 24: 211-3.
2. Haraguchi H, Inoue J, Tamura Y, Mizutani K. Antioxidative components of Psoralea corylifolia (Leguminosae). Phytother Res 2002; 16: 539-44.
3. Ji L, Xu Z. Review of constituents in fruits of Psoralea corylifolia L. Zhongguo Zhong Yao Za Zhi 1995; 20: 120-2, 8.
4. Bruhlmann C, Ooms F, Carrupt PA, Testa B, Catto M, Leonetti F et al. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. J Med Chem 2001; 44: 3195-8.
5. Kang SY, Lee KY, Sung SH, Park MJ, Kim YC. Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. J Nat Prod 2001; 64: 683-5.
6. Kang SY, Lee KY, Park MJ, Kim YC, Markelonis GJ, Oh TH et al. Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol Learn Mem 2003; 79: 11-8.
7. Liston DR, Nielsen JA, Villalobos A, Chapin D, Jones SB, Hubbard ST et al. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. Eur J Pharmacol 2004; 486: 9-17.
8. Wu CR, Hsieh MT, Huang SC, Peng WH, Chang YS, Chen CF. Effects of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats. Planta Med 1996; 62: 317-21.
9. Blokland A. Acetylcholine: a neurotransmitter for learning and memory? Brain Res Brain Res Rev 1995; 21: 285-300.
10. Bejar C, Wang RH, Weinstock M. Effect of rivastigmine on scopolamine-induced memory impairment in rats. Eur J Pharmacol 1999; 383: 231-40.
11. Badia A, Banos JE, Camps P, Contreras J, Gorbig DM, Munoz-Torrero D et al. Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. Bioorg Med Chem 1998; 6: 427-40.
12. Rollinger JM, Hornick A, Langer T, Stuppner H, Prast H. Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products. J Med Chem 2004; 47: 6248-54.
13. Botwinick CY, Quartermain D. Recovery from amnesia induced by pretest injections of monoamine oxidase inhibitors. Pharmacol Biochem Behav 1974; 2: 375-9.
14. Kong LD, Tan RX, Woo AY, Cheng CH. Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol 2001; 88: 75-80.
15. Lagatolla C, Dolzani L, Granzotto M, Monti-Bragadin C. Genotoxic activity of 4,4′,5′-trimethylazapsoralen on plasmid DNA. Teratog Carcinog Mutagen 1998; 18: 239-48.
16. Stern RS, Liebman EJ, Vakeva L. Oral psoralen and ultraviolet-A light (PUVA) treatment of psoriasis and persistent risk of nonmelanoma skin cancer. PUVA Follow-up Study. J Natl Cancer Inst 1998; 90: 1278-84.
17. Chang HM, But PPH. Pharmacology and application of Chinese Materia Medica. Singapore: World Scientific; 1986: 636-41
18. Hsieh MT, Hsieh CL, Wang WH, Chen CS, Lin CJ, Wu CR. Osthole improves aspects of spatial performance in ovariectomized rats. Am J Chin Med 2004; 32: 11-20.
19. Ellman GL, Courtney KD, Andres V Jr., Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.