메뉴 건너뛰기




Volumn 37, Issue 5, 2007, Pages 1386-1396

NF-κB-regulated suppression of T-bet in T cells represses Th1 immune responses in pregnancy

Author keywords

Cytokines; Human; T cells; Th1 Th2 cells; Transcription factors

Indexed keywords

CD3 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; IONOMYCIN; OLIGODEOXYRIBONUCLEOTIDE; SN 50; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21; UNCLASSIFIED DRUG;

EID: 34250337265     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636322     Document Type: Article
Times cited : (40)

References (42)
  • 1
    • 0027207375 scopus 로고
    • Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon?
    • Wegmann, T. G., Lin, H., Guilbert, L. and Mosmann, T. R., Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol. Today 1993. 14: 353-356.
    • (1993) Immunol. Today , vol.14 , pp. 353-356
    • Wegmann, T.G.1    Lin, H.2    Guilbert, L.3    Mosmann, T.R.4
  • 3
    • 1642334209 scopus 로고    scopus 로고
    • Pregnancy-specific down-regulation of NF-kappa B expression in T cells in humans is essential for the maintenance of the cytokine profile required for pregnancy success
    • McCracken, S. A., Gallery, E. and Morris, J. M., Pregnancy-specific down-regulation of NF-kappa B expression in T cells in humans is essential for the maintenance of the cytokine profile required for pregnancy success. J. Immunol. 2004. 172: 4583-4591.
    • (2004) J. Immunol , vol.172 , pp. 4583-4591
    • McCracken, S.A.1    Gallery, E.2    Morris, J.M.3
  • 5
    • 0029017478 scopus 로고
    • IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau
    • Chaouat, G., Assal Meliani, A., Martal, J., Raghupathy, R., Elliot, J., Mosmann, T. and Wegmann, T. G., IL-10 prevents naturally occurring fetal loss in the CBA × DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J. Immunol. 1995. 154: 4261-4268.
    • (1995) J. Immunol , vol.154 , pp. 4261-4268
    • Chaouat, G.1    Assal Meliani, A.2    Martal, J.3    Raghupathy, R.4    Elliot, J.5    Mosmann, T.6    Wegmann, T.G.7
  • 6
    • 0032781755 scopus 로고    scopus 로고
    • Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus
    • Ostensen, M., Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1999. 876: 131-143.
    • (1999) Ann. N. Y. Acad. Sci , vol.876 , pp. 131-143
    • Ostensen, M.1
  • 7
    • 0020530070 scopus 로고
    • Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis
    • Ostensen, M., Aune, B. and Husby, G., Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis. Scand. J. Rheumatol. 1983. 12: 69-72.
    • (1983) Scand. J. Rheumatol , vol.12 , pp. 69-72
    • Ostensen, M.1    Aune, B.2    Husby, G.3
  • 8
    • 0032900439 scopus 로고    scopus 로고
    • New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases
    • Chen, F., Castranova, V., Shi, X. and Demers, L. M., New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 1999. 45: 7-17.
    • (1999) Clin. Chem , vol.45 , pp. 7-17
    • Chen, F.1    Castranova, V.2    Shi, X.3    Demers, L.M.4
  • 9
    • 0032711223 scopus 로고    scopus 로고
    • Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo
    • Aronica, M. A., Mora, A. L., Mitchell, D. B., Finn, P. W., Johnson, J. E., Sheller, J. R. and Boothby, M. R., Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J. Immunol. 1999. 163: 5116-5124.
    • (1999) J. Immunol , vol.163 , pp. 5116-5124
    • Aronica, M.A.1    Mora, A.L.2    Mitchell, D.B.3    Finn, P.W.4    Johnson, J.E.5    Sheller, J.R.6    Boothby, M.R.7
  • 10
    • 0029671317 scopus 로고    scopus 로고
    • Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells
    • Lederer, J. A., Liou, J. S., Kim, S., Rice, N. and Lichtman, A. H., Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells. J. Immunol. 1996. 156: 56-63.
    • (1996) J. Immunol , vol.156 , pp. 56-63
    • Lederer, J.A.1    Liou, J.S.2    Kim, S.3    Rice, N.4    Lichtman, A.H.5
  • 11
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson, N. G., Szabo, S. J., Weber-Nordt, R. M., Zhong, Z., Schreiber, R. D., Darnell, J. E. Jr. and Murphy, K. M., Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 1995. 181: 1755-1762.
    • (1995) J. Exp. Med , vol.181 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell Jr., J.E.6    Murphy, K.M.7
  • 13
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000. 100: 655-669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 14
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P. and Glimcher, L. H., Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002. 295: 338-342.
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 15
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto, S., Neurath, M. F., Glickman, J. N., Qin, S., Lehr, H. A., Green, F. H., Ackerman, K. et al., Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002. 295: 336-338.
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3    Qin, S.4    Lehr, H.A.5    Green, F.H.6    Ackerman, K.7
  • 16
    • 0041589416 scopus 로고    scopus 로고
    • T cell-intrinsic requirement for NF-kappa B induction in post differentiation IFN-gamma production and clonal expansion in a Th1 response
    • Corn, R. A., Aronica, M. A., Zhang, F., Tong, Y., Stanley, S. A., Kim, S. R., Stephenson, L. et al., T cell-intrinsic requirement for NF-kappa B induction in post differentiation IFN-gamma production and clonal expansion in a Th1 response. J. Immunol. 2003. 171: 1816-1824.
    • (2003) J. Immunol , vol.171 , pp. 1816-1824
    • Corn, R.A.1    Aronica, M.A.2    Zhang, F.3    Tong, Y.4    Stanley, S.A.5    Kim, S.R.6    Stephenson, L.7
  • 17
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin, Y. Z., Yao, S. Y., Veach, R. A., Torgerson, T. R. and Hawiger, J., Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 1995. 270: 14255-14258.
    • (1995) J. Biol. Chem , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 18
    • 0033553524 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced proliferation of human Mo7e leukemic cells occurs via activation of nuclear factor kappaB transcription factor
    • Liu, R. Y., Fan, C., Olashaw, N. E., Wang, X. and Zuckerman, K. S., Tumor necrosis factor-alpha-induced proliferation of human Mo7e leukemic cells occurs via activation of nuclear factor kappaB transcription factor. J. Biol. Chem. 1999. 274: 13877-13885.
    • (1999) J. Biol. Chem , vol.274 , pp. 13877-13885
    • Liu, R.Y.1    Fan, C.2    Olashaw, N.E.3    Wang, X.4    Zuckerman, K.S.5
  • 19
    • 0029939162 scopus 로고    scopus 로고
    • Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor
    • Kalkhoven, E., Wissink, S., van der Saag, P. T. and van der Burg, B., Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor. J. Biol. Chem. 1996. 271: 6217-6224.
    • (1996) J. Biol. Chem , vol.271 , pp. 6217-6224
    • Kalkhoven, E.1    Wissink, S.2    van der Saag, P.T.3    van der Burg, B.4
  • 21
    • 0034794829 scopus 로고    scopus 로고
    • Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions
    • Makhseed, M., Raghupathy, R., Azizieh, F., Omu, A., Al-Shamali, E. and Ashkanani, L., Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum. Reprod. 2001. 16: 2219-2226.
    • (2001) Hum. Reprod , vol.16 , pp. 2219-2226
    • Makhseed, M.1    Raghupathy, R.2    Azizieh, F.3    Omu, A.4    Al-Shamali, E.5    Ashkanani, L.6
  • 23
    • 0027992524 scopus 로고
    • Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha
    • Pimentel-Muinos, F. X., Mazana, J. and Fresno, M., Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha. J. Biol. Chem. 1994. 269: 24424-24429.
    • (1994) J. Biol. Chem , vol.269 , pp. 24424-24429
    • Pimentel-Muinos, F.X.1    Mazana, J.2    Fresno, M.3
  • 24
    • 33746609802 scopus 로고    scopus 로고
    • Elevated circulating IL-1beta and TNF-alpha, and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome
    • Vitoratos, N., Papadias, C., Economou, E., Makrakis, E., Panoulis, C. and Creatsas, G., Elevated circulating IL-1beta and TNF-alpha, and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome. Mediators Inflamm. 2006. 2006: 30485-30490.
    • (2006) Mediators Inflamm , vol.2006 , pp. 30485-30490
    • Vitoratos, N.1    Papadias, C.2    Economou, E.3    Makrakis, E.4    Panoulis, C.5    Creatsas, G.6
  • 25
    • 33845639549 scopus 로고    scopus 로고
    • Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
    • Dawson, H. D., Collins, G., Pyle, R., Key, M., Weeraratna, A., Deep-Dixit, V., Nadal, C. N. and Taub, D. D., Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006. 7: 27-41.
    • (2006) BMC Immunol , vol.7 , pp. 27-41
    • Dawson, H.D.1    Collins, G.2    Pyle, R.3    Key, M.4    Weeraratna, A.5    Deep-Dixit, V.6    Nadal, C.N.7    Taub, D.D.8
  • 26
    • 0025809325 scopus 로고
    • Human rumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines
    • Goldfeld, A. E., Strominger, J. L. and Doyle, C., Human rumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines. J. Exp. Med. 1991. 174: 73-81.
    • (1991) J. Exp. Med , vol.174 , pp. 73-81
    • Goldfeld, A.E.1    Strominger, J.L.2    Doyle, C.3
  • 27
    • 30744457828 scopus 로고    scopus 로고
    • T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression
    • Long, M., Slaiby, A. M., Hagymasi, A. T., Mihalyo, M. A., Lichtler, A. C., Reiner, S. L. and Adler, A. J., T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression. J. Immunol. 2006. 176: 1036-1045.
    • (2006) J. Immunol , vol.176 , pp. 1036-1045
    • Long, M.1    Slaiby, A.M.2    Hagymasi, A.T.3    Mihalyo, M.A.4    Lichtler, A.C.5    Reiner, S.L.6    Adler, A.J.7
  • 28
    • 0030045393 scopus 로고    scopus 로고
    • Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN - gamma response and increased production of T helper 2 cytokines
    • Krishnan, L., Guilbert, L. J., Russell, A. S., Wegmann,T. G., Mosmann, T. R. and Belosevic, M., Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN - gamma response and increased production of T helper 2 cytokines. J. Immunol. 1996. 156: 644-652.
    • (1996) J. Immunol , vol.156 , pp. 644-652
    • Krishnan, L.1    Guilbert, L.J.2    Russell, A.S.3    Wegmann, T.G.4    Mosmann, T.R.5    Belosevic, M.6
  • 33
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu, J., Cote-Sierra, J., Guo, L. and Paul, W. E., Stat5 activation plays a critical role in Th2 differentiation. Immunity 2003. 19: 739-748.
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4
  • 34
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang, E. S., Szabo, S. J., Schwartzberg, P. L. and Glimcher, L. H., T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005. 307: 430-433.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 35
    • 13844269244 scopus 로고    scopus 로고
    • Cyclosporin A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells
    • Nishiyama, S., Manabe, N., Kubota, Y., Ohnishi, H., Kitanaka, A., Tokuda, M., Taminato, T. et al., Cyclosporin A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells. Int. Immunopharmacol. 2005. 5: 699-710.
    • (2005) Int. Immunopharmacol , vol.5 , pp. 699-710
    • Nishiyama, S.1    Manabe, N.2    Kubota, Y.3    Ohnishi, H.4    Kitanaka, A.5    Tokuda, M.6    Taminato, T.7
  • 36
    • 0029041568 scopus 로고
    • Transcriptional regulation of the IL-2 gene
    • Jain, J., Loh, C. and Rao, A., Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 1995,. 7: 333-342.
    • (1995) Curr. Opin. Immunol , vol.7 , pp. 333-342
    • Jain, J.1    Loh, C.2    Rao, A.3
  • 37
    • 0037386353 scopus 로고    scopus 로고
    • Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF
    • Kwak-Kim, J. Y., Chung-Bang, H. S., Ng, S. C., Ntrivalas, E. I., Mangubat, C. P., Beaman, K. D., Beer, A. E. and Gilman-Sachs, A., Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum. Reprod. 2003. 18: 767-773.
    • (2003) Hum. Reprod , vol.18 , pp. 767-773
    • Kwak-Kim, J.Y.1    Chung-Bang, H.S.2    Ng, S.C.3    Ntrivalas, E.I.4    Mangubat, C.P.5    Beaman, K.D.6    Beer, A.E.7    Gilman-Sachs, A.8
  • 38
    • 0036488848 scopus 로고    scopus 로고
    • Pregnancy is associated with suppression of the nuclear factor kappa B/I kappa B activation pathway in peripheral blood mononuclear cells
    • McCracken, S. A., Drury, C. L., Lee, H. S. and Morris, J. M., Pregnancy is associated with suppression of the nuclear factor kappa B/I kappa B activation pathway in peripheral blood mononuclear cells. J. Reprod. Immunol. 2003. 58: 27-47.
    • (2003) J. Reprod. Immunol , vol.58 , pp. 27-47
    • McCracken, S.A.1    Drury, C.L.2    Lee, H.S.3    Morris, J.M.4
  • 39
    • 0033237645 scopus 로고    scopus 로고
    • Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection
    • Aljada, A., Ghanim, H., Assian, E., Mohanty, P., Hamouda, W., Garg, R. and Dandona, P., Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection. J. Clin. Endocrinol. Metab. 1999. 84: 3386-3389.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 3386-3389
    • Aljada, A.1    Ghanim, H.2    Assian, E.3    Mohanty, P.4    Hamouda, W.5    Garg, R.6    Dandona, P.7
  • 40
    • 0032230316 scopus 로고    scopus 로고
    • A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids
    • Wissink, S., van Heerde, E. C., van der Burg, B. and van der Saag, P. T., A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids. Mol. Endocrinol. 1998. 12: 355-363.
    • (1998) Mol. Endocrinol , vol.12 , pp. 355-363
    • Wissink, S.1    van Heerde, E.C.2    van der Burg, B.3    van der Saag, P.T.4
  • 42
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    • Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S. and Baltimore, D., Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995. 376: 167-170.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.