Increased IκB expression and diminished nuclear NF-κB in human mononuclear cells following hydrocortisone injection

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 9, 1999, Pages 3386-3389

  Aljada, A ^a   Ghanim, H ^a   Assian, E ^a   Mohanty, P ^a   Hamouda, W ^a   Garg, R ^a   Dandona, P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; REACTIVE OXYGEN METABOLITE; DNA BINDING PROTEIN; I KAPPA B;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LYSATE; CELL NUCLEUS; GENE EXPRESSION; HORMONE ACTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; INTRACELLULAR TRANSPORT; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN TRANSPORT; CYTOSOL; DRUG EFFECT; IMMUNOBLOTTING; KINETICS; METABOLISM; MIDDLE AGED; ULTRASTRUCTURE; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CELL NUCLEUS; CYTOSOL; DNA-BINDING PROTEINS; HUMANS; HYDROCORTISONE; I-KAPPA B PROTEINS; IMMUNOBLOTTING; KINETICS; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; NF-KAPPA B; REACTIVE OXYGEN SPECIES;

EID: 0033237645     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.9.6104     Document Type: Article

References (21)

1. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
2. Mechanisms of corticosteroid action on lymphocyte subpopulations. II. Differential effects of in vivo hydrocortisone, prednisone and dexamethasone on in vitro expression of lymphocyte function
3. Transcription factors AP-1 and NF-kappa B: Where steroids meet the gold standard of anti-rheumatic drugs
4. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
5. Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids
6. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
7. Negative cross-talk between Re1A and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids
8. Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation
9. Effect of hydrocortisone on oxygen free radical generation by mononuclear cells
10. Hydrocortisone induced inhibition of reactive oxygen species (ROS) by polymorphonuclear (PMN) leucocytes
11. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
12. A rapid, specific assay for superoxide release from phagocytes in small volumes of whole blood
13. The Inhibition of Diphenylene Iodonium and Its Analogues of Superoxide Generation by Macrophages
14. Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins
15. The respiratory burst oxidase
16. Increase in plasma interleukin-10 following hydrocortisone injection
17. Effect of dexamethasone on ROS generation by leucocytes and IL-10 concentration: A pharmacodynamic study
18. Properties and functions of interleukin-10
19. Biological properties of interleukin 10
20. Interleukin-10