In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja

Planta Medica

Volumn 73, Issue 5, 2007, Pages 478-479

  Philippe, Geneviève ^a   De Mol, Patrick ^a   Angenot, Luc ^a   Tits, Monique ^a   Frédérich, Michel ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ISOSUNGUCINE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM VINCKEI; STRYCHNOS; STRYCHNOS ICAJA;

ANIMALS; ANTIMALARIALS; FEMALE; INDOLE ALKALOIDS; MICE; PLASMODIUM; STRYCHNOS;

MURINAE; STRYCHNOS ICAJA;

EID: 34250322702     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-967174     Document Type: Article

References (16)

1. Greenwood BM, Bojang K, Whitty CJM, Targett GAT. Malaria. Lancet 2005; 365: 1487-98.
2. Hyde JE. Drug-resistant malaria. Trends Parasitol 2005; 21: 494-8.
3. Neuwinger HD. Alkaloids in arrow poisons. In: Roberts MC, Wink M, editors. Alkaloids: biochemistry, ecology and medicinal applications New York: Plenum Press; 1998: 45-84.
4. Neuwinger HD. African ethnobotany: Poisons and drugs, chemistry, pharmacology, toxicology. London: Chapman & Hall; 1996: 569-78.
5. Iwu M. Handbook of African medicinal plants. Boca Raton: CRC Press; 1993:244-5.
6. Wright CW, Bray DH, O'Neill MJ, Warhurst DC, Phillipson JD, Quetin-Leclercq J et al. Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. Planta Med 1991; 57: 337-40.
7. Wright CW, Allen D, Cai Y, Chen ZP, Phillipson JD, Kirby GC et al. Selective antiprotozoal activity of some Strychnos alkaloids. Phytother Res 1994; 8: 149-52.
8. Frederich M, Hayette MP, Tits M, De Mol P, Angenot L. In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum. Antimicrob Agents Chemother 1999; 43: 2328-31.
9. Frederich M, Tits M, Coffin E, Philippe G, Grellier P, De Mol P et al. In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis. Planta Med 2004; 70: 520-5.
10. Frederich M, De Pauw M, Prosperi C, Tits M, Brandt V, Penelle J et al. Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja. J Nat Prod 2001; 64: 12-6.
11. Philippe G, Nguyen L, Angenot L, Frederich M, Moonen G, Tits M et al. Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor. Eur J Pharmacol 2006; 530: 15-22.
12. Frederich M, Depauw-Gillet MC, Llabres G, Tits M, Hayette MP, Brandt V et al. New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots. Planta Med 2000; 66: 262-9.
13. Peters W, Robinson BL. The chemotherapy of rodent malaria. XLV1. Reversal of mefloquine resistance in rodent Plasmodium. Ann Trop Med Hyg 1991; 85: 5-10.
14. Pink R, Hudson A, Mouries MA, Bendig M. Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov 2005; 4: 727-40.
15. Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov 2004; 3: 509-20.
16. Frederich M, Jacquier MJ, Thepenier P, De Mol P, Tits M, Philippe G et al. Antiplasmodial activity of alkaloids from various Strychnos species. J Nat Prod 2002; 65: 1381-6.