Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents

European Journal of Medicinal Chemistry

Volumn 42, Issue 7, 2007, Pages 893-901

  Küçükgüzel, Ş Güniz ^a   Küçükgüzel, Ilkay ^a   Tatar, Esra ^a   Rollas, Sevim ^a   Şahin, Fikrettin ^b,c   Güllüce, Medine ^b   De Clercq, Erik ^d   Kabasakal, Levent ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

^c YEDITEPE UNIVERSITY   (Turkey)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1,2,4 Triazoline 3 thione; 1,3,4 Oxadiazole; 1,3,4 Thiadiazole; Anti inflammatory agents; Diflunisal

Indexed keywords

1,2,4 TRIAZOLINE 3 THIONE DERIVATIVE; 1,3,4 OXADIAZOLE DERIVATIVE; 1,3,4 THIADIAZOLE DERIVATIVE; 2',4' DIFLUORO 4 HYDROXYBIPHENYL 3 CARBOXYLIC ACID DERIVATIVE; AMPHOTERICIN B; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CEFEPIME; DIFLUNISAL; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS; BACTERIAL CELL; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; NOCICEPTION; NONHUMAN; STREPTOCOCCUS PYOGENES; TRICHOPHYTON RUBRUM;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIA; DIFLUNISAL; FEMALE; FUNGI; HETEROCYCLIC COMPOUNDS; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PAIN; VIRUSES;

EID: 34250200740     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.12.038     Document Type: Article

References (27)

1. Küçükgüzel S.G., Rollas S., Erdeniz H., and Kiraz M. Eur. J. Med. Chem. 34 2 (1999) 153-160
2. Küçükgüzel S.G., Rollas S., Erdeniz H., Kiraz M., Ekinci A.C., and Vidin A. Eur. J. Med. Chem. 35 (2000) 761-771
3. Foroumadi A., Soltani F., Moshafi M.H., and Ashraf-Askari R. Il Farmaco 58 (2003) 1023-1028
4. Foroumadi A., Mansouri S., Kiani Z., and Rahmani A. Eur. J. Med. Chem. 38 (2003) 851-854
5. Kalgutkar A.S., Marnett A.B., Crews B.C., Remmel R.P., and Marnett L.J. J. Med. Chem 43 (2000) 2860-2870
6. Nargund L.V.G., Reddy G.R.N., and Hariprasad V. J. Pharm. Sci. 83 (1994) 246-248
7. Al-Deeb O.A., Al-Omar M.A., El-Brollosy N.R., Habib E.E., İbrahim T.M., and El-Emam A.A. Arzneim. Forsch. Drug. Res. 56 (2006) 40-47
8. Navidpour L., Shafaroodi H., Abdi K., Amini M., Ghahremani M.H., Dehpour A.R., and Shafiee A. Bioorg. Med. Chem. 14 (2006) 2507-2517
9. Varandas L.S., Fraga C.A.M., Miranda A.L.P., and Barreiro E.J. Lett. Drug. Des. Discov. 2 (2005) 62-67
10. Schenone S., Brullo C., Bruno O., Bondavalli F., Ranise A., Filippelli W., Rinaldi B., Capuano A., and Falcone G. Bioorg. Med. Chem. 14 (2006) 1698-1705
11. Küçükgüzel S.G., Mazi A., Şahin F., Öztürk S., and Stables J.P. Eur. J. Med. Chem. 38 (2003) 1005-1013
12. Küçükgüzel S.G., Kocatepe A., De Clercq E., Şahin F., and Güllüce M. Eur. J. Med. Chem. 41 (2006) 353-359
13. Şahin F., Karaman I., Güllüce M., Öǧütçü H., Şengül M., Adi{dotless}güzel A., Öztürk S., and Kotan R. J. Ethnopharmacol. 87 (2002) 61-65
14. Güllüce M., Adi{dotless}güzel A., Öǧütçü H., Şengül M., and Şahin F. Phytother. Res. 18 (2004) 208-211
15. Güllüce M., Sökmen M., Şahin F., Sökmen A., Adi{dotless}güzel A., and Özer H. J. Sci. Food Agric. 84 (2004) 735-741
16. Pauwels R., Balzarini J., Baba M., Snoeck R., Schols D., Herdewijn P., Desmyter J., and De Clercq E. J. Virol. Methods 20 (1988) 309-321
17. Popovic M., Sarngadharan M.G., Read E., and Gallo R.C. Science 224 (1984) 497-500
18. Barré-Sinoussi F., Chermann J.C., Nugeyre M.T., Chamaret S., Grest J., Dauget C., Axler-Blin C., Vézinet-Brun F., Rouzioux C., Rozenbaum W., and Montagnier L. Science 220 (1983) 868-871
19. Miyoshi I., Taguchi H., Kobonishi I., Yoshimoto S., Ohtsuki Y., Shiraishi Y., and Akagi T. Gann Monogr. 28 (1982) 219-228
20. De Clercq E., Descamps J., Verhelst G., Walker R.T., Jones A.S., Torrence P.F., and Shugar D. J. Infect. Dis 141 5 (1980) 563-574
21. Kasahara Y., Hikino H., Tsurufuji S., Watanabe M., and Ohuchi M. Planta Med. 51 (1985) 325
22. Woolfe G., and Mc Donald A.D. J. Pharmacol. Exp. Ther. 80 (1944) 300-307
23. Zhao Y., Abraham M.H., Lee J., Hersey A., Luscombe N.Ch., Beck G., Sherborne B., and Cooper I. Pharm. Res. 19 (2002) 1446
24. http://www.molinspiration.com
25. Ertl P., Rohde B., and Selzer P. J. Med. Chem. 43 (2000) 3714
26. Rollas S., Kalyoncuoglu N., Sur-Altiner D., and Yegenoglu Y. Pharmazie 48 (1993) 308-309
27. Rollas S., Karakus S., Durgun B.B., Kiraz M., and Erdeniz H. Il Farmaco 51 (1996) 811-814