Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India

Ophthalmic Genetics

Volumn 28, Issue 2, 2007, Pages 77-81

  Uthra, Satagopan ^a   Raman, Rajiv ^b   Mukesh, Bickol N ^c   Padmaja, Kumari R ^b   Paul, Pradeep G ^c   Lakshmipathy, Praveena ^a   Gnanamoorthy, Perumal ^c   Sharma, Tarun ^b   McCarty, Catherine A ^d   Kumaramanickavel, Govindasamy ^a  

^a VISION RESEARCH FOUNDATION   (India)

^b Bhagwan Mahavir Vitreo Retinal Services   (India)

^c MEDICAL RESEARCH FOUNDATION   (India)

^d MARSHFIELD CLINIC   (United States)

Author keywords

Diabetic retinopathy; eNOS; Hypoxia; Intronic VNTR; Type 2 diabetes

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; INDIA; INTRON; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RETINA MACULA EDEMA; VARIABLE NUMBER OF TANDEM REPEAT;

ALLELES; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GENOTYPE; HUMANS; INDIA; INTRONS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 34250195037     PISSN: 13816810     EISSN: 17445094     Source Type: Journal    
DOI: 10.1080/13816810701209669     Document Type: Article

References (26)

1. Fukumura D, Gohongi T, Kadambi A, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA. 2001;98:2604-2609.
2. Bredt, DS, Snyder, SH. Nitric oxide: A physiologic messenger molecule. Annu Rev Biochem. 1994;63:175-195.
3. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med. 1994;120(3):227-237.
4. Albrecht EW, Stegeman CA, Heeringa P, Henning RH, van Goor H. Protective role of endothelial nitric oxide synthase. J Pathol. 2003;199(1):8-17.
5. Lee PC, Salyapongse AN, Bragdon GA, Shears II LL, Watkins SC, Edington HDJ, Billiar TR. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol. 1999; 277 (Heart Circ. Physiol. 46: H1600-H1608.
6. Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge R, Yancopoulos GD, Adamis AP. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in Vivo. Am J Pathol. 2002;160:501-509.
7. Marsden PA, Heng HH, Scherer SW, Stewart RJ, Hall AV, Shi XM, Tsui LC, Schappert KT. Structure and chromosomal localization of the Human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 1993;268(23):17478- 17488.
8. Zanchi A, Moczulski DK, Hanna LS, Wantman M, Warram JH, Krolewski AS. Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney Int. 2000;57(2):405-413.
9. Li C, Dong Y, Lu W. The association between polymorphism of endothelial nitric oxide synthase gene and diabetic nephropathy. Zhonghua Nei Ke Za Zhi. 2001;40(11):729-732.
10. Persu A, Vinck WJ, Khattabi OE, Janssen RG, Paulussen AD, Devuyst O, Vlietinck R, Fagard RH. Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study. J Hypertens. 2005;23(4):759-765.
11. Monti LD, Barlassina C, Citterio L, Galluccio E, Berzuini C, Setola E, Valsecchi G, Lucotti P, Pozza G, Bernardinelli L, Casari G, Piatti P. Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes. 2003;52(5):1270-1275.
12. Neugebauer S, Baba T, Watanabe T. Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes. Diabetes. 2000 49:500-503.
13. Frost D, Chitu J, Meyer M, Beischer W, Pfohl M. Endothelial nitric oxide synthase (eNOS) 4 a/b gene polymorphism and carotid artery intima-media thickness in type-1 diabetic patients. Exp Clin Endocrinol Diabetes. 2003;111(1):12-15.
14. Taverna MJ, Sola A, Guyot-Argenton C, Pacher N, Bruzzo F, Chevalier A, Slama G, Reach G, Selam JL. eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy. Diabet. Med. 2002;19:240-245.
15. Rani PK, Raman R, Agarwal S, Paul PG, Uthra S, Margabandhu G, Senthilkumar D, Kumaramanickavel G, Sharma T. Diabetic retinopathy screening model for rural population: awareness and screening methodology. Rural Remote Health. 2005;5(4):350.
16. Agarwal S, Raman R, Paul PG, Rani PK, Uthra S, Gayathree R, McCarty C, Kumaramanickavel G, Sharma T. Sankara Nethralaya-Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS 1): study design and research methodology. Ophthalmic Epidemiol. 2005;12(2):143-153.
17. Klein R, Klein BEK, Magli YL, Brothers RJ, Meuer SM, Moss SE, Davis MD. An alternative method of grading diabetic retinopathy. Ophthalmology. 1986;93:1183-1187.
18. World Medical Organization. Declaration of Helsinki. Br Med J. 1996;313(7070) 1448-1449.
19. Wolff R, Gemmil R. Purifying and analysing genomic DNA. In: Bruce B, Green ED, Hieter P, Klaplholz S, Myeres RM, Riethman H, editors. Genome analysis a laboratory manual, vol. 4. New York: Cold Spring Harbour Laboratory Press 1998; 1-82.
20. Sambrook J, Fritsch EF, Manniatis T. Gel electrophoresis of DNA. In: Molecular cloning: A laboratory manual, 2nd edition, Vol. 1. New York: Cold Spring Harbour Laboratory Press, 1997;6:3-6.44.
21. Hattenbach L, Allers A, Klais C, Koch F, Hecker M. L-arginine-nitric oxide pathway-related metabolites in the aqueous humor of diabetic patients. IOVS. 2000;41:213-217.
22. Tsukada T, Yokoyama K, Arai T, Takemoto F, Hara S, Yamada A, Kawaguchi Y, Hosoya T, Igari J. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun. 1998;245:190-193.
23. Awata T, Neda T, Iizuka H, Kurihara S, Ohkubo T, Takata N, Osaki M, Watanabe M, Nakashima Y, Sawa T, Inukai K, Inoue I, Shibuya M, Mori K, Yoneya S, Katayama S. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Diabetes Care. 2004; 27:2184-2190.
24. Suganthalakshmi B, Anand R, Kim R, Mahalakshmi R, Karthikprakash S, Namperumalsamy P. Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol Vis. 2006;12:336-341.
25. Wang J, Dudley D, Wang XL. Haplotype-specific effects on endothelial NO synthase promoter efficiency: Modifiable by cigarette smoking. Arterioscler Thromb Vasc Biol. 2002;22:e1-e4.
26. de Syllos RW, Sandrim VC, Lisboa HR, Tres GS, Tanus-Santos JE. Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. Nitric Oxide 2006 Dec;15(4):417-422.