eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy

Diabetic Medicine

Volumn 19, Issue 3, 2002, Pages 240-245

  Taverna, M J ^a   Sola, A ^a   Guyot Argenton, C ^a   Pacher, N ^a   Bruzzo, F ^a   Chevalier, A ^a   Slama, G ^a   Reach, G ^a   Selam, J L ^a  

^a HÔTEL DIEU   (France)

Author keywords

Diabetic retinopathy; eNOS4 polymorphism; Genetic; Nitric oxide

Indexed keywords

GENOMIC DNA; NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; BODY MASS; CAUCASIAN; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREDICTION; RANDOMIZATION; RETINA ANGIOGRAPHY; RISK ASSESSMENT;

ADULT; AGE OF ONSET; ALLELES; DATABASES, FACTUAL; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; DNA PRIMERS; ENDOTHELIUM, VASCULAR; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FRANCE; GENOTYPE; HETEROZYGOTE DETECTION; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; ODDS RATIO; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 0036229138     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-5491.2002.00681.x     Document Type: Article

References (31)

1. Radicals and oxidative stress in diabetes
2. Nitric oxide in the pathogenesis of vascular disease
3. Nitric oxide and vascular responses in type 1 diabetes
4. The dual personality of NO
5. The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years
6. Clustering of long-term complications in families with diabetes in the diabetes control and complications trial
7. Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes
8. Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism
9. Lack of contribution of two endothelial nitric oxide synthase (eNOS) gene polymorphisms to diabetic nephropathy in type 1 diabetes
10. Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy
11. Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases
12. Dinucleotide repeat polymorphisms in EDN1 and NOS3 are not associated with severe diabetic retinopathy in type 1 or type 2 diabetes
13. Genotyping and functional analysis of a polymorphism (CCTTT)(n) repeat of NOS2A in diabetic retinopathy
14. CCTTT-repeat polymorphism in the human NOS2-promoter confers low risk of diabetic nephropathy in type 1 diabetic patients
15. Methodology for retinal photography and assessment of diabetic retinopathy: The EURODIAB IDDM complications study
16. Diabetic retinopathy
17. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene
18. Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population
19. Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury
20. Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy
21. Serum markers of oxidative stress and severity of diabetic retinopathy
22. Role of vascular endothelial growth factor in diabetic vascular complications
23. Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF
24. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
25. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
26. Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice
27. Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy
28. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans
29. Chromosome 7q35 and susceptibility to diabetic microvascular complications
30. Genetic analysis of nitric oxide and endothelin in end-stage renal disease
31. Antisense oligodeoxynucleotide to inducible nitric oxide synthase protects against transient focal cerebral ischemia-induced brain injury