Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice

Biomedicine and Pharmacotherapy

Volumn 61, Issue 5, 2007, Pages 292-297

  Benkovic, V ^a   Horvat Knezevic, A ^a   Brozovic, G ^b   Knezevic, F ^b   Dikic, D ^a   Bevanda, M ^c   Basic, I ^a   Orsolic, N ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^c Clinical Hospital   (Bosnia and Herzegovina)

Author keywords

Ehrlich ascites tumor; Flavonoids; Irinotecan; Propolis; Tumor growth

Indexed keywords

ALCOHOL; IRINOTECAN; POLYPHENOL DERIVATIVE; PROPOLIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG POTENTIATION; DRUG SOLUBILITY; EHRLICH ASCITES TUMOR; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME; SWISS WEBSTER MOUSE; TREATMENT DURATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARCINOMA, EHRLICH TUMOR; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FLAVANONES; FLAVONOIDS; MALE; MICE; PHENOLS; PROPOLIS; QUERCETIN;

EID: 34250186070     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2007.02.012     Document Type: Article

References (36)

1. Aso K., Kanno S., Tadano T., Satoh S., and Ishikawa M. Inhibitory effect of propolis on the growth of human leukemia U937. Biol Pharm Bull 27 5 (2004) 727-730
2. Bankova V. Recent trends and important developments in propolis research. Evidence-based Complement Alternat Med 2 1 (2005) 29-32
3. Boege F., Straub T., Kehr A., Boesenberg C., Christiansen K., Andersen A., et al. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic Topoisomerase I. J Biol Chem 271 4 (1996) 2262-2270
4. Chang C.C., Yang M.H., Wen H.M., and Chern J.C. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 10 (2002) 178-182
5. Chen C.-N., Weng M.-S., Wu C.-L., and Lin J.-K. Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources. Evidence-based Complement Alternat Med 1 2 (2004) 175-185
6. Constantinou A., Mehta R., Runyan C., Rao K., Vaughan A., and Moon R. Flavonoids as DNA Topoisomerase antagonists and poisons: structure-activity relationships. J Nat Prod 58 2 (1995) 217-225
7. El-khawaga O.A., Salem T.A., and Elshal M.F. Protective role of Egyptian propolis against tumor in mice. Clin Chim Acta 338 (2003) 11-16
8. Galati G., and O`Brien P.J. Potential toxicity of flavorous and other dietary phenolics: Significance for their chemopreventive and anticancer properties. Serial review: Flavonoids and isoflavones (phytoestrogens): absorbtion, metabolism, and bioactivity. Free Radic Biol Med 37 3 (2004) 287-303
9. Galati G., Sabzevari O., Wilson J.X., and O`Brien P.J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other poliphenolics. Toxicology 177 (2002) 91-104
10. Grynberg N.F., Carvalho M.G., Velandia J.R., Oliveira M.C., Moreira I.C., Braz-Filho R., et al. DNA Topoisomerase inhibitors: biflavonoids from Ouratea species. Braz J Med Biol Res 35 7 (2002) 819-822
11. Gupta M., Mazumder U.K., Kumar R.S., and Kumar T.S. Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice. Acta Pharmacol Sin 25 8 (2004) 1070-1076
12. Khantamat O., Wittaya Chaiwangyen M.S., and Porn-ngarm Limtrakul M.S. Screening of flavonoids for their potential Inhibitory effect on p-glycoprotein activity in human cervical carcinoma Kb cells. Chiang Mai Med Bull 43 2 (2004) 45-56
13. Kosalec I., Bakmaz M., and Pepeljnjak S. Analysis of propolis from the continental and Adriatic regions of Croatia. Acta Pharm 53 4 (2003) 275-285
14. Kosalec I., Bakmaz M., Pepelnjak S., and Knežević S. Quantitative analysis of the flavonoids in raw propolis from northern Croatia. Acta Pharm 54 (2004) 65-72
15. Kumazawa S.H., Yoneda M., Shibata I., Kanaeda J., Hamasaka T., and Nakayama T.S. Direct evidence for the plant origin of Brazilian propolis by the observation of honeybee behavior and phytochemical analysis. Chem Pharm Bull 51 (2003) 740-742
16. Ledon N., Casaco A., Gonzalez R., Merino N., Gonzalez A., and Tolon Z. Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis. Zhongguo Yao Li Xue Bao 18 3 (1997) 274-276
17. López-Lázaro M., Martín-Cordero C., Toro M.V., and Ayuso M.J. Flavonoids as DNA Topoisomerase I Poisons. J Enzyme Inhib Med Chem 233 2 (2006) 255-264
18. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52 4 (2000) 673-751
19. Ng T.B., Liu F., and Wang Z.T. Antioxidative activity of natural products from plants. Life Sci 66 8 (2000) 709-723
20. Nijveldt R.J., Van Nood E., Van Hoorn D.E., Boelens P.G., Van Norren K., and Van Leeuwen P.A. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74 4 (2001) 418-425
21. Orsolic N., and Basic I. Immunomodulation by water-soluble derivative of propolis (WSDP) a factor of antitumor reactivity. J Ethnopharmacol 84 (2003) 265-273
22. Orsolic N., Brbot Saranovic A., and Basic I. Direct and indirect mechanism(s) of antitumor activity of propolis and its polyphenolic compounds. Planta Med 72 (2005) 14-19
23. Orsolic N., Horvat-Knezevic A., and Basic I. Propolis as a new potential immunomodulator in mice: antimetastatic activity of a water-soluble derivate of propolis (WSDP). Mellifera 2 (2002) 29-46
24. Orsolic N., Kosalec I., and Basic I. Synergystic antitumor effect of polyphenolic components of water soluble derivative of propolis against Ehrlich ascites tumour. Biol Pharm Bull 28 4 (2005) 694-700
25. Plowman J., Dykes D.J., Hollingshead M., Simpson-Herren L., and Alley M.C. Human tumor xenograft models in NCI drug development. In: Teicher B. (Ed). Anticancer development guide: preclinical screening, clinical trials, and approval (1997), Humana Press, Totowa, NJ 101-125
26. Popova M., Bankova V., Butovska D., Petkov V., Nikolova-Damyanova B., Sabatini A.G., et al. Validated methods for the quantification of biologically active constituents of poplar-type propolis. Phytochem Anal 15 (2004) 235-240
27. Popova M., Bankova V., Naydensky C.H., Tsvetkova I., and Kujumgiev A. Comparative study of the biological activity of propolis from different geographic origin: a statistical approach. Macedonian Pharm Bull 50 (2004) 9-14
28. Rice-Evans C. Flavonoid antioxidants. Review. Curr Med Chem 8 7 (2001) 797-807
29. Scambia G., Ranelletti F.O., Benedetti Panici P., Bonanno G., De Vincenzo R., Piantelli M., et al. Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth. Anticancer Drugs 1 (1990) 45-48
30. Scambia G., Ranelletti F.O., Panici P.B., Bonanno G., De Vincenzo R., Piantelli M., et al. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 34 6 (1994) 459-464
31. Schluep T., Hwang J., Cheng J., Heidel J.D., Barlett D.W., Hollister B., et al. Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models. Clin Cancer Res 12 5 (2006) 1606-1614
32. Sestili P., Guidarelli A., Dacha M., and Cantoni O. Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism. Free Radic Biol Med 25 2 (1998) 196-200
33. Suzuki I., Hayashi I., Takaki T., Groveman D.S., and Fujimiya Y. Antitumor and anticytopenic effects of aqueous extracts of propolis in combination with chemotherapeutic agents. Cancer Biother Radiopharm 17 5 (2002) 553-562
34. Webb M.R., and Ebeler S.E. Comparative analysis of topoisomerase IB inhibition and DNA intercalation by flavonoids and similar compounds: structural determinates of activity. Biochem J 384 (2004) 527-541
35. Yamashita Y., Kawada S., Fujii N., and Nakano H. Induction of mammalian DNA Topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin. Cancer Res 50 18 (1990) 5841-5844
36. Yen G.C., Duh P.D., Tsai H.L., and Huang S.L. Pro-oxidative properties of flavonoids in human lymphocytes. Biosci Biotechnol Biochem 67 6 (2003) 1215-1222