Analysis of APC/beta-catenin genes mutations and Wnt signalling pathway in desmoid-type fibromatosis

Pathology

Volumn 39, Issue 3, 2007, Pages 319-325

  Jilong, Yang ^a   Jian, Wang ^b   Xiaoyan, Zhou ^b   Xiaoqiu, Li ^b   Xiongzeng, Zhu ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Adenomatous polyposis coli gene; Beta catenin gene; Desmoid type fibromatosis; Gene mutation; Wnt signalling pathway

Indexed keywords

APC PROTEIN; BETA CATENIN; CYCLIN D1; KI 67 ANTIGEN; MYC PROTEIN; WNT PROTEIN;

ARTICLE; CODON; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DESMOID TUMOR; EXON; FIBROMATOSIS; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MUTATIONAL ANALYSIS; NICK END LABELING; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TISSUE FIXATION;

APOPTOSIS; BASE SEQUENCE; BETA CATENIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIN D1; FIBROMATOSIS, AGGRESSIVE; GENES, APC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MUTATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYC; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 34250168296     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1080/00313020701329823     Document Type: Article

References (20)

1. Tejpar S, Michils G, Denys H, et al. Analysis of Wnt/Beta catenin signalling in desmoid tumors. Acta Gastroenterol Belg 2005; 68: 5-9.
2. Fearnhead NS, Britton MP, Bodmer WF, et al. The ABC of APC. Hum Mol Genet 2001; 10: 721-33.
3. Doucas H, Garcea G, Neal CP, et al. Changes in the Wnt signaling pathway in gastrointestinal cancers and their prognostic significance. Eur J Cancer 2005; 41: 365-79.
4. Kikuchi A. Regulation of beta-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun 2000; 268: 243-8.
5. Sparks AB, Morin PJ, Vogelstein B, et al. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998; 58: 1130-4.
6. Tejpar S, Michils G, Denys H, et al. Analysis of Wnt/Beta catenin signaling in desmoid tumors. Acta Gastroenterol Belg 2005; 68: 5-9.
7. Maruyama K, Ochiai A, Akimoto S, et al. Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer. Oncology 2000; 59: 302-9.
8. Ogawa K, Yaginuma Y. Beta-catenin. Nippon Rinsho 2001; 59 (Suppl 6): 161-6.
9. Miyaki M, Konishi M, Kikuchi-Yanoshita R, et al. Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis. Cancer Res 1993; 53: 5076-82.
10. Dequanter D, Gebhart M. Desmoid tumors. J Chir (Paris) 2002; 139: 236-9.
11. Sturt NJ, Gallagher MC, Bassett P, et al. Evidence for genetic predisposition to desmoid tumors in familial adenomatous polyposis independent of the germline APC mutation. Gut 2004; 53: 1832-6.
12. Hosalkar HS, Fox EJ, Delaney T, et al. Desmoid tumors and current status of management. Orthop Clin North Am 2006; 37: 53-63.
13. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000; 103: 311-20.
14. Horrii A, Nakatsuru S, Ichii S, et al. Multiple isoforms of the APC gene transcripts and their tissue-specific expression. Hum Mol Genet 1993; 2: 283-7.
15. van Es J, Giles R, Clevers H. The many faces of the tumor suppressor gene APC. Exp Cell Res 2001; 264: 126-34.
16. Ramburan A, Oladiran F, Smith C, et al. Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of βcatenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy. J Clin Pathol 2005; 58: 44-50.
17. Cheon SS, Cheah AY, Turley S, et al. Beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci USA 2002; 99: 6973-8.
18. Koesters R, Niggli F, von Knebel Doeberitz M, et al. Nuclear accumulation of beta-catenin protein in Wilms' tumours. J Pathol 2003; 199: 68-76.
19. Sharma H, Sen S, Sheriff AK, et al. Characterization of apoptosis-related molecular changes in a desmoid tumor of the chest wall: report of a case. Surg Today 2003; 33: 358-62.
20. Pelengaris S, Rudolph B, Littlewood T. Action of Myc in vivo - proliferation and apoptosis. Curr Opin Genet Dev 2000; 10: 100-5.